Results 141 to 150 of about 1,598,447 (336)

Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma

SLAS Discovery
High Throughput Screening (HTS) with 3D cell models is possible thanks to the recent progress and development in 3D cell culture technologies. Results from multiple studies have demonstrated different drug responses between 2D and 3D cell culture.
Luis M. Ortiz Jordan, Virneliz Fernández Vega, Justin Shumate, Adam Peles, Jordan Zeiger, Louis Scampavia, Timothy P. Spicer   +6 more
doaj   +1 more source

Advancing Electronic Application of Coordination Solids: Enhancing Electron Transport and Device Integration via Surface‐Mounted MOFs (SURMOFs)

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of coordination solids, enabled by the surface‐mounted metal‐organic framework (SURMOF) platform, is on the cusp of generating the organic counterpart of the epitaxy of inorganics. The programmable and sequential SURMOF protocol, optimized by machine learning (ML), is suited for accessing high‐quality thin films of ...
Zhengtao Xu, Christof Wöll, Stefan Bräse   +2 more
wiley   +1 more source

Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors

SLAS Technology
Covalent drug discovery has garnered renewed interest due to its potential to target proteins previously considered ''undruggable.'' Intact protein mass spectrometry (MS) is a critical technique for providing direct evidence of covalent drug ...
Ronghai Cheng, Adil Muneer, Maria Hercher, Bekim Bajrami, Reza Nemati   +4 more
doaj   +1 more source

High-throughput, microplate reader detection of the ASP+ fluorescent substrate to identify novel inhibitors of organic cation transporter-3 [PDF]

, 2023
Rheaclare Fraser‐Spears, Ann M. Decker, Bruce E. Blough, Lynette C. Daws   +3 more
openalex   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

High‐Throughput Miniaturized Synthesis of PROTAC‐Like Molecules [PDF]

Ye Tian, Maximilian Seifermann, Liana Bauer, Charlotte Luchena, Janne J. Wiedmann, S. Schmidt, Alexander Geisel, Sergii Afonin, Julius Höpfner, Marius Brehm, Xinyong Liu, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +13 more
openalex   +1 more source

Quantum Emitters in Hexagonal Boron Nitride: Principles, Engineering and Applications

Advanced Functional Materials, EarlyView.
Quantum emitters in hexagonal boron nitride have emerged as a promising candidate for quantum information science. This review examines the fundamentals of these quantum emitters, including their level structures, defect engineering, and their possible chemical structures.
Thi Ngoc Anh Mai, Md Shakhawath Hossain, Nhat Minh Nguyen, Yongliang Chen, Chaohao Chen, Xiaoxue Xu, Quang Thang Trinh, Toan Dinh, Toan Trong Tran   +8 more
wiley   +1 more source

Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus

Scientific Reports
Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes employing error-prone replicases. Thereby, they routinely generate a large ‘
Sandra Triebel, Kevin Lamkiewicz, Nancy Ontiveros, Blake Sweeney, Peter F. Stadler, Anton I. Petrov, Michael Niepmann, Manja Marz   +7 more
doaj   +1 more source

The Power of High‐Throughput Experimentation in Homogeneous Catalysis Research for Fine Chemicals [PDF]

, 2003
Johannes G. de Vries, André H. M. de Vries   +1 more
openalex   +1 more source

Single Pair of Weyl Points Evolve From Spin Group‐Protected Nodal Line in Half‐Metallic Ferromagnet V3S4

Advanced Functional Materials, EarlyView.
A spin group (SG)‐based mechanism is proposed to realize a single pair of Weyl points. PT‐symmetric nodal lines (NLs) persist under T‐breaking, protected by the combination of SG and P symmetry. When considering spin‐orbit coupling, the SG‐protected NL will split into Weyl points, which will also induce anomalous transport phenomena arising from ...
Shifeng Qian, Yao Zhang, Xiaowei Sheng, Xiuxian Yang, Gang Zhang, Junfeng Gao, Xiaotian Wang   +6 more
wiley   +1 more source