Results 141 to 150 of about 1,835 (171)

Protocol for isolating human extracellular vesicles from nephrotic urine and enriching autoimmunoglobulin-triggered extracellular vesicles. [PDF]

STAR Protoc
Lahme K, Meyer-Schwesinger C.
europepmc   +1 more source

From immune dysregulation to renal injury: mechanistic insights and translational opportunities in immune-mediated nephropathies. [PDF]

Front Cell Dev Biol
Wang X.
europepmc   +1 more source

Zebrafish Thsd7a Is a Neural Protein Required for Angiogenic Patterning During Development [PDF]

Developmental Dynamics, 2011
AbstractAngiogenesis is a highly organized process under the control of guidance cues that direct endothelial cell (EC) migration. Recently, many molecules that were initially described as regulators of neural guidance were subsequently shown to also direct EC migration.
Yung-Jen Chuang
exaly   +4 more sources

Autoantigens PLA2R and THSD7A in Membranous Nephropathy Share a Common Epitope Motif in the N-Terminal Domain

Journal of Autoimmunity, 2020
Patients with membranous nephropathy have autoantibodies against PLA2R (up to 80%), or THSD7A (up to 2%). We previously described the immunodominant epitope within PLA2R but epitopes in THSD7A are still unknown.
Rachel Lennon, Thomas A Jowitt, I Roberts   +2 more
exaly   +2 more sources

THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients With Squamous Cell Carcinoma of the Lung [PDF]

International Journal of Molecular Sciences, 2023
Lung cancer is the leading cause of cancer-related deaths in the western world, with squamous cell carcinoma being one of the most common histological subtypes.
Frank Langer, Rainer Maria Böhle
exaly   +3 more sources

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THSD7A as a Promising Biomarker for Membranous Nephrosis

Molecular Biotechnology, 2023
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and one of the leading causes of nephrotic syndrome. The disease exhibits heterogeneous outcomes with approximately 30% of cases progressing to end-stage renal disease. Traditionally, the standard approach of diagnosing MN involves performing a kidney biopsy.
Shuiqing Jiang, Dehua Jiang, Zhiyuan Lian, Xiaohong Huang, Ting Li, Yinan Zhang   +5 more
openaire   +2 more sources

Motor Neuron-Derived Thsd7a Is Essential for Zebrafish Vascular Development via the Notch-dll4 Signaling Pathway [PDF]

Journal of Biomedical Science, 2016
BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Li-En Jao, Yung-Jen Chuang, Zih-Yin Lai
exaly   +2 more sources

THSD7A Expression in Human Cancer

Genes Chromosomes and Cancer, 2017
AbstractWe recently described a case of a Thrombospondin Type‐1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A‐positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different ...
Elion Hoxha, Rolf A K Stahl, Ronald Simon   +2 more
exaly   +3 more sources

Treatment of Membranous Nephropathy in Patients With THSD7A Antibodies Using Immunoadsorption

American Journal of Kidney Diseases, 2019
Antibodies against THSD7A (thrombospondin type 1 domain-containing protein 7A) have been proposed to play a causal role in the development of nephrotic syndrome in patients with THSD7A antibody-positive membranous nephropathy. We hypothesized that removal of these antibodies from plasma could lead to a rapid reduction in proteinuria.
Kerstin Amann, Julia Weinmann-Menke, Maike Büttner-Herold   +2 more
exaly   +3 more sources