Results 1 to 10 of about 2,837 (170)

Serum PLA2R-IgG4/PLA2R-IgG ratio dynamics reveal pathogenic autoantibody subclass switch during progression of PLA2R-associated membranous nephropathy [PDF]

Annals of Medicine
Background Pathogenic autoantibody subclass switch has been found in lots of autoimmune disease. However, the information on anti-phospholipase A2 receptor antibody subclass switch in membranous nephropathy (MN) is limited and controversial. Here, we aim
Yongzhong Zhong, Yunyun Liu, Dan Zhou, Jing Tian, Dacheng Chen, Dandan Liang, Shaoshan Liang, Tianyu Zhen, Xiaodong Zhu, Biao Huang, Caihong Zeng   +10 more
doaj   +4 more sources

Analysis of glomerular PLA2R efficacy in evaluating the prognosis of idiopathic membranous nephropathy in the background of different serum anti-PLA2R levels

Renal Failure, 2022
Objective To verify glomerular PLA2R antigen and serum PLA2R antibody expression in membranous nephropathy as well as to explore glomerular PLA2R efficacy in evaluating the prognosis of idiopathic membranous nephropathy (IMN) in the background of ...
Yuemeng Sun, Ping Lan, Jie Feng, Zhigang Wang, Chao Liu, Liyi Xie, Xiaoyang Yu   +6 more
exaly   +3 more sources

PLA2R-Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report. [PDF]

Clin Case Rep
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Abreham B, Hamza L, Kebede A, Bekele DR, Amdemariam Z.   +4 more
europepmc   +2 more sources

Spontaneous Remission of Late Relapsing Membranous Nephropathy After Previous Immunosuppressant-Induced Remission: Case Report. [PDF]

Case Rep Nephrol
This is the first detailed report of spontaneous remission of late relapsing membranous nephropathy (MN) after previous immunosuppressant‐induced remission. In March 2004, a 52‐year‐old Hispanic male presented with severe nephrotic syndrome with proteinuria of 13 g/24 h. The workup for infectious and autoimmune diseases was unrevealing.
Cao Y.
europepmc   +2 more sources

The cutoff value and prognosis of anti-PLA2R antibody for idiopathic membranous nephropathy: a single-center retrospective study in China

Renal Failure, 2023
Serum anti-phospholipase A2 receptor (anti-PLA2R) antibody is used for the noninvasive diagnosis of idiopathic membranous nephropathy (IMN). However, the cutoff value of anti-PLA2R antibodies in IMN patients is debatable.
Jiansuo Zhou, Danxia Zheng
exaly   +3 more sources

Role of PLA2R domain antibodies and epitope spreading in risk stratification and prediction of proteinuria remission in primary membranous nephropathy

Scientific Reports
The clinical significance of phospholipase A2 receptor (PLA2R) antigen domain-specific antibodies has not been determined. We investigated the role of serum PLA2R domain antibodies and epitope spreading in risk stratification and proteinuria remission in
Feiya Yang, Feiya Yang
exaly   +2 more sources

Always Consider a Repeat Kidney Biopsy: Acute Interstitial Nephritis Soon After Membranous Nephropathy. [PDF]

Case Rep Nephrol
Introduction The heterogeneity of membranous nephropathy is well described in the literature, and its clinical course and response to treatment vary. Similarly, acute interstitial nephritis (AIN) can present in unexpected and unusual ways and should always be considered within the differential diagnosis of worsening renal function.
Hopkins J, Nolan J, Ladhani M, Lee C.
europepmc   +2 more sources

Serum and urine anti-PLA2R antibody correlation with albuminuria in idiopathic membranous nephropathy [PDF]

Frontiers in Immunology
ObjectiveThis study aimed to investigate the correlation between anti-phospholipase A2 receptor (PLA2R) levels in serum and urine with clinical parameters, particularly albuminuria, in patients with idiopathic membranous nephropathy (IMN).MethodsWe ...
Xiaogang Liu, Yunfei Fu, Manshu Sui, Xuehua Wang, Zizhen Li   +4 more
doaj   +2 more sources

Retrospective study: clinicopathological features and prognosis of idiopathic membranous nephropathy with seronegative anti-phospholipase A2 receptor antibody [PDF]

PeerJ, 2020
Background To discuss the clinicopathological features and prognosis of patients with idiopathic membranous nephropathy (IMN) who are serum-negative for the anti-PLA2R antibody.
Wenkai Guo, Yan Zhang, Caifeng Gao, Jing Huang, Jiatong Li, Rong Wang, Bing Chen   +6 more
doaj   +2 more sources

PLA2R-IgG4 antibody as a predictive biomarker of treatment effectiveness and prognostic evaluation in patients with idiopathic membranous nephropathy: a retrospective study [PDF]

PeerJ, 2022
Background The Kidney Disease Improving Global Outcomes (KDIGO) 2021 guidelines recommend Rituximab (RTX) as the first-line therapy and phospholipase A2 receptor (PLA2R) antibody as a biomarker for remission and prognosis in patients with idiopathic ...
Yiqing Huang, Junyi Zhou, Kezhi Zhou, Biao Huang, Jing Xue, Xiran Zhang, Bin Liu, Zhijian Zhang, Leting Zhou, Ting Cai, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +13 more
doaj   +2 more sources