Results 1 to 10 of about 30,858,840 (226)

Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy. [PDF]

J Inflamm Res, 2023
Ning-Qiu Xie,1,* Yu-Lin Zhang,2,* Zi-Li Zheng,1 Quan-Lin Zheng,1 Ruo-Ji Chen1 1Department of Nephrology, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China; 2Department of Pediatric, Jinjiang Municipal Hospital ...
Xie NQ, Zhang YL, Zheng ZL, Zheng QL, Chen RJ.   +4 more
europepmc   +5 more sources

Presence of M-type Phospholipase A2 Receptor Antibody in Membranous Nephropathy

Turkish Journal of Nephrology, 2020
Objective: The presence of autoantibodies against M-type phospholipase A2 receptor (anti-PLA2R) is a characteristic of idiopathic membranous nephropathy (IMN).
Özgür Akın Oto, Halil Yazıcı, Yaşar Çalışkan, Ayşe Serra Artan, Mehmet Şükrü Sever, Egemen Cebeci, Savaş Öztürk, Aydın Türkmen   +7 more
doaj   +3 more sources

A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium. [PDF]

Clin Med Insights Case Rep, 2022
A 70-year-old man was referred to our department for evaluation of nephrotic syndrome. Renal biopsy revealed membranous nephropathy (MN). Immunohistochemical analysis demonstrated IgG4-positive staining in the glomeruli and interstitial cells.
Ishibuchi K, Iwakura T, Ema C, Ema C, Nakagami D, Uchiyama Y, Kaneko M, Fukasawa H, Matsuyama T, Yasuda H, Furuya R.   +10 more
europepmc   +5 more sources

The level and clinical significance of serum soluble M-type phospholipase A2 receptor in patients with primary membranous nephropathy. [PDF]

Ren Fail
Primary membranous nephropathy (PMN) is a kidney-specific autoimmune glomerular disease, M-type phospholipase A2 receptor (PLA2R1) is the target antigen. However, the level of PLA2R1 in PMN patients serum remains unclear.
Wang ZH, Gao YM, Deng ZL, Wang Y.
europepmc   +4 more sources

Treatment resistant M-type phospholipase A2 receptor associated membranous nephropathy responds to obinutuzumab: a report of two cases. [PDF]

BMC Nephrol, 2022
Background Membranous Nephropathy (MN) is a common cause of nephrotic syndrome (NS) in adults. Recognition of MN as an antibody mediated autoimmune disease has enabled the introduction of anti-B-cell therapy.
Hudson R, Rawlings C, Mon SY, Jefferis J, John GT.   +4 more
europepmc   +6 more sources

Development of a Standardized Chemiluminescence Immunoassay for the Detection of Autoantibodies Against Human M-Type Phospholipase A2 Receptor in Primary Membranous Nephropathy. [PDF]

Kidney Int Rep, 2020
Introduction: Autoantibodies against the M-type phospholipase A2 receptor (PLA2R) are important markers in the diagnosis and monitoring of primary membranous nephropathy (pMN).
Dähnrich C, Saschenbrecker S, Gunnarsson I, Schlumberger W, Ronco P, Debiec H.   +5 more
europepmc   +2 more sources

Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Autoantibody: One-Year Experience in Quebec's Reference Center. [PDF]

Can J Kidney Health Dis, 2021
Background: Quantification of the M-type phospholipase A2 receptor antibodies (anti-PLA2R) is now an essential tool for diagnosis and management of primary membranous nephropathy (MN).
Leclerc S, Benkirane K, Nadeau-Fredette AC, Elftouh N, Lafrance JP, Pichette V, Royal V, Lamarche C, Laurin LP.   +8 more
europepmc   +2 more sources

PLA2R-IgG4 antibody as a predictive biomarker of treatment effectiveness and prognostic evaluation in patients with idiopathic membranous nephropathy: a retrospective study [PDF]

PeerJ, 2022
Background The Kidney Disease Improving Global Outcomes (KDIGO) 2021 guidelines recommend Rituximab (RTX) as the first-line therapy and phospholipase A2 receptor (PLA2R) antibody as a biomarker for remission and prognosis in patients with idiopathic ...
Yiqing Huang, Junyi Zhou, Kezhi Zhou, Biao Huang, Jing Xue, Xiran Zhang, Bin Liu, Zhijian Zhang, Leting Zhou, Ting Cai, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +13 more
doaj   +2 more sources

Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study

Acta Clinica Croatica, 2021
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB).
Mario Laganović, Ivica Horvatić, Ivan Bubić, Mario Ilić, Bojana Maksimović, Ana Kozmar, Ivana Vuković Brinar, Matija Crnogorac, Marijana Živko, Margareta Fištrek, Željka Jureković, Danica Galešić Ljubanović, Marijana Ćorić, Stela Bulimbašić, Krešimir Galešić, Mladen Knotek   +15 more
doaj   +1 more source

HBx-induced PLA2R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway

Renal Failure, 2023
Introduction Hepatitis B virus-associated glomerulonephritis (HBV-GN) is one of the main types of secondary glomerular diseases, and podocyte injury is an important pathogenic mechanism of HBV-GN, participating in the occurrence and development of HBV-GN.
Moxuan Feng, Yani Yu, Yueqi Chen, Xiaoqian Yang, Baoshuang Li, Wei Jiang   +5 more
doaj   +1 more source