A Case of M-Type Phospholipase A2 Receptor-Associated Membranous Nephropathy With IgG4-Positive Cells Infiltration in the Interstitium [PDF]
Clinical Medicine Insights: Case Reports, 2022 A 70-year-old man was referred to our department for evaluation of nephrotic syndrome. Renal biopsy revealed membranous nephropathy (MN). Immunohistochemical analysis demonstrated IgG4-positive staining in the glomeruli and interstitial cells.
Kento Ishibuchi +9 more
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Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy [PDF]
Journal of Inflammation Research, 2023 Ning-Qiu Xie,1,* Yu-Lin Zhang,2,* Zi-Li Zheng,1 Quan-Lin Zheng,1 Ruo-Ji Chen1 1Department of Nephrology, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China; 2Department of Pediatric, Jinjiang Municipal Hospital ...
Xie NQ +4 more
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Treatment resistant M-type phospholipase A2 receptor associated membranous nephropathy responds to obinutuzumab: a report of two cases [PDF]
BMC Nephrology, 2022 Background Membranous Nephropathy (MN) is a common cause of nephrotic syndrome (NS) in adults. Recognition of MN as an antibody mediated autoimmune disease has enabled the introduction of anti-B-cell therapy.
Rebecca Hudson +4 more
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The level and clinical significance of serum soluble M-type phospholipase A2 receptor in patients with primary membranous nephropathy [PDF]
Renal FailurePrimary membranous nephropathy (PMN) is a kidney-specific autoimmune glomerular disease, M-type phospholipase A2 receptor (PLA2R1) is the target antigen. However, the level of PLA2R1 in PMN patients serum remains unclear.
Zi-Han Wang +3 more
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Presence of M-type Phospholipase A2 Receptor Antibody in Membranous Nephropathy
Turkish Journal of Nephrology, 2020 Objective: The presence of autoantibodies against M-type phospholipase A2 receptor (anti-PLA2R) is a characteristic of idiopathic membranous nephropathy (IMN).
Özgür Akın Oto +7 more
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Development of a Standardized Chemiluminescence Immunoassay for the Detection of Autoantibodies Against Human M-Type Phospholipase A2 Receptor in Primary Membranous Nephropathy [PDF]
Kidney International Reports, 2020 Introduction: Autoantibodies against the M-type phospholipase A2 receptor (PLA2R) are important markers in the diagnosis and monitoring of primary membranous nephropathy (pMN).
Cornelia Dähnrich +5 more
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Qualitative and Quantitative Dosage of the Anti M-Type Phospholipase A2 Receptor Autoantibody: One-Year Experience in Quebec’s Reference Center [PDF]
Canadian Journal of Kidney Health and Disease, 2021 Background: Quantification of the M-type phospholipase A2 receptor antibodies (anti-PLA2R) is now an essential tool for diagnosis and management of primary membranous nephropathy (MN).
Simon Leclerc +8 more
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M-type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy. [PDF]
Clin J Am Soc Nephrol, 2014 Loss of renal function in patients with primary membranous nephropathy cannot be reliably predicted by laboratory or clinical markers at the time of diagnosis. M-type phospholipase A2 receptor autoantibodies have been shown to be associated with changes in proteinuria.
Hoxha E +4 more
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Diagnostic Usefulness of Antibodies Against M-type Phospholipase A2 Receptor (aPLA2R) in Primary Membranous Nephropathy in the Mexican Population. [PDF]
Cureus, 2023 This study aimed to determine the frequency and diagnostic performance of antibodies against M-type phospholipase A2 receptors (aPLA2R) in subjects with idiopathic membranous nephropathy (IMN).A diagnostic test study was conducted in a cohort of 160 patients from the nephrology outpatient clinic over a period of eight years.
Diaz Garcia JD.
europepmc +3 more sources
sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. [PDF]
Sci Rep, 2014 The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes in human glomeruli. Group IB secretory phospholipase A2 (sPLA2 IB), which is one of the ligands of the PLA2R, is more highly expressed in chronic renal failure patients than in controls.
Pan Y +7 more
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