Results 41 to 50 of about 30,858,840 (226)

Advances in antigens associated with Idiopathic Membranous Nephropathy

Journal of the Formosan Medical Association, 2021
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Idiopathic MN (IMN), one of the forms of MN, usually has an unknown etiology. IMN is described as an autoimmune disease, and its pathogenesis is quite complex.
Shan-Shan Li, Dong-E Tang, Yong Dai
doaj   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Primary Membranous Nephropathy With Enhanced Staining of Exostosin 1/Exostosin 2 in the Glomeruli: A Report of 2 Cases

Kidney Medicine, 2021
Technological advances have allowed the discovery of 6 subtypes of membranous nephropathy based on target antigens: M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), neural epidermal growth factor-like 1 ...
Takamasa Iwakura, Chiemi Ema, Taichi Sato, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda   +7 more
doaj   +1 more source

Aberrant methylation of the M-type phospholipase A2 receptor gene in leukemic cells [PDF]

BMC Cancer, 2012
The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression and methylation of the PLA2R1 gene in Jurkat and U937 leukemic cell lines and its methylation in patients with myelodysplastic syndrome (MDS) or acute leukemia.Sites of methylation of the ...
Menschikowski Mario, Platzbecker Uwe, Hagelgans Albert, Vogel Margot, Thiede Christian, Schönefeldt Claudia, Lehnert Renate, Eisenhofer Graeme, Siegert Gabriele   +8 more
openaire   +3 more sources

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

Journal of Lipid Research, 2000
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice
Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

Glucocorticoid receptor stabilization: Relative effects of molybdate ion on inactivation by alkaline phosphatase and phospholipase A2 [PDF]

, 1983
Glucocorticoid receptors in cytosol preparations from rat liver or mouse L cells are inactivated by phospholipase A2 or calf intestine alkaline phosphatase. Molybdate ion, an inhibitor of a variety of phosphatase enzymes, does not prevent inactivation of
Pratt, William B., Dahmer, Mary K., Leach, Karen L.   +2 more
core   +1 more source

Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment

Frontiers in Immunology, 2022
Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte antigens causing in situ immune complex deposition.
Edmund Y. M. Chung, Yuan M. Wang, Karen Keung, Min Hu, Hugh McCarthy, Hugh McCarthy, Hugh McCarthy, Germaine Wong, Germaine Wong, Lukas Kairaitis, Bhadran Bose, David C. H. Harris, David C. H. Harris, Stephen I. Alexander, Stephen I. Alexander   +14 more
doaj   +1 more source

Supplemental material for Antibodies to M-type phospholipase A2 receptor (PLA₂R) in membranous lupus nephritis

, 2019
Supplemental Material for Antibodies to M-type phospholipase A2 receptor (PLA2R) in membranous lupus nephritis by E Garcia-Vives, C Solé, T Moliné, A M Alvarez-Rios, M Vidal, I Agraz, J Ordi-Ros and J Cortés-Hernández in ...
J Cortés-Hernández (6338060), C Solé (6338042), I Agraz (6338054), E Garcia-Vives (6338039), J Ordi-Ros (6338057), A M Alvarez-Rios (6338048), M Vidal (6338051), T Moliné (6338045)   +7 more
core   +1 more source

Immunohistochemical analysis for thrombospondin type-1 domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R).

, 2015
Immunostaining for THSD7A (a, c, e) and PLA2R (b, d, f) in patients with idiopathic membranous nephropathy (a–d) and secondary membranous nephropathy (e, f). Original magnification: ×400.
Hideo Yasuda (710367), Satoshi Baba (540358), Naro Ohashi (168272), Akihiko Kato (798462), Takamasa Iwakura (798461)   +4 more
core   +1 more source

Lysosomal phospholipase A2: a novel player in host immunity to Mycobacterium tuberculosis. [PDF]

, 2014
Phospholipases catalyze the cleavage of membrane phospholipids into smaller bioactive molecules. The lysosomal phospholipase A2 (LPLA2 ) is specifically expressed in macrophages.
Hagens, Kristine, James A. Shayman, Shayman, James A., Jochen Behrends, Schneider, Bianca E, Schneider, Bianca E., Harmel, Nadine, Shayman, James A, Nadine Harmel, Bianca E. Schneider, Ulrich E. Schaible, Behrends, Jochen, Schaible, Ulrich E, Schaible, Ulrich E., Kristine Hagens   +14 more
core   +1 more source