Results 41 to 50 of about 26,727 (247)

Clinical significance of antibodies to the M-type phospholipase A2 receptor in patients with primary membranous nephropathy

Clinical pharmacology and therapy, 2023
To evaluate the significance of circulating antibodies to the M-type phospholipase A2 receptor (anti-PLA2R) in the diagnosis of primary membranous nephropathy (MN) and the determination of the clinical features of the disease.
O.A. Li, E.Y. Andreeva, I.N. Bobkova, E.S. Kamyshova, P.A. Kakhsurueva   +4 more
openaire   +1 more source

Aberrant methylation of the M-type phospholipase A2 receptor gene in leukemic cells [PDF]

BMC Cancer, 2012
The M-type phospholipase A2 receptor (PLA2R1) plays a crucial role in several signaling pathways and may act as tumor-suppressor. This study examined the expression and methylation of the PLA2R1 gene in Jurkat and U937 leukemic cell lines and its methylation in patients with myelodysplastic syndrome (MDS) or acute leukemia.Sites of methylation of the ...
Menschikowski Mario, Platzbecker Uwe, Hagelgans Albert, Vogel Margot, Thiede Christian, Schönefeldt Claudia, Lehnert Renate, Eisenhofer Graeme, Siegert Gabriele   +8 more
openaire   +3 more sources

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

Journal of Lipid Research, 2000
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice
Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment

Frontiers in Immunology, 2022
Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte antigens causing in situ immune complex deposition.
Edmund Y. M. Chung, Yuan M. Wang, Karen Keung, Min Hu, Hugh McCarthy, Hugh McCarthy, Hugh McCarthy, Germaine Wong, Germaine Wong, Lukas Kairaitis, Bhadran Bose, David C. H. Harris, David C. H. Harris, Stephen I. Alexander, Stephen I. Alexander   +14 more
doaj   +1 more source

Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. [PDF]

PLoS ONE, 2015
Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), which mainly belong to the IgG4 subclass, were ...
Takamasa Iwakura, Naro Ohashi, Akihiko Kato, Satoshi Baba, Hideo Yasuda   +4 more
doaj   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Lysosomal phospholipase A2: a novel player in host immunity to Mycobacterium tuberculosis. [PDF]

, 2014
Phospholipases catalyze the cleavage of membrane phospholipids into smaller bioactive molecules. The lysosomal phospholipase A2 (LPLA2 ) is specifically expressed in macrophages.
Hagens, Kristine, James A. Shayman, Shayman, James A., Jochen Behrends, Schneider, Bianca E, Schneider, Bianca E., Harmel, Nadine, Shayman, James A, Nadine Harmel, Bianca E. Schneider, Ulrich E. Schaible, Behrends, Jochen, Schaible, Ulrich E, Schaible, Ulrich E., Kristine Hagens   +14 more
core   +1 more source

Serum and urine anti-PLA2R antibody correlation with albuminuria in idiopathic membranous nephropathy

Frontiers in Immunology
ObjectiveThis study aimed to investigate the correlation between anti-phospholipase A2 receptor (PLA2R) levels in serum and urine with clinical parameters, particularly albuminuria, in patients with idiopathic membranous nephropathy (IMN).MethodsWe ...
Xiaogang Liu, Yunfei Fu, Manshu Sui, Xuehua Wang, Zizhen Li   +4 more
doaj   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
core   +1 more source

The Spectrum of Biopsy‐Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
This 20‐year retrospective study reveals a significant increase in renal biopsy utilization and a pivotal shift in biopsy‐proven renal disease among Chinese elderly patients. Secondary glomerular nephropathy (particularly diabetic nephropathy and hypertensive nephropathy) has surpassed primary glomerular nephropathy as the leading biopsy‐proven ...
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin Liu   +4 more
wiley   +1 more source