Results 21 to 30 of about 30,858,840 (226)

Endocytic Properties of the M-type 180-kDa Receptor for Secretory Phospholipases A2 [PDF]

Journal of Biological Chemistry, 1996
Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2 (sPLA2) were first investigated in rabbit myocytes that express it at high levels. Internalization of the receptor was shown to be clathrin-coated pit-mediated, rapid (ke = 0.1 min-1), and ligand-independent.
E, Zvaritch, G, Lambeau, M, Lazdunski
openaire   +2 more sources

Structural Elements of Secretory Phospholipases A2 Involved in the Binding to M-type Receptors [PDF]

Journal of Biological Chemistry, 1995
Specific membrane receptors for secretory phospholipases A2 (sPLA2s) have been initially identified with novel snake venom sPLA2s called OS1 and OS2. One of these sPLA2 receptors (muscle (M)-type, 180 kDa) has a very high affinity for OS1 and OS2 and a high affinity for pancreatic and inflammatory-type mammalian sPLA2s, which might be the natural ...
G, Lambeau, P, Ancian, J P, Nicolas, S H, Beiboer, D, Moinier, H, Verheij, M, Lazdunski   +6 more
openaire   +2 more sources

Advances in Pathogenesis of Idiopathic Membranous Nephropathy

Kidney Diseases, 2020
Background: Membranous nephropathy (MN), a major cause of nephrotic syndrome, has attracted people’s attention in recent years for its growing prevalence.
Zhifeng Xu, Lu Chen, Huiling Xiang, Chun Zhang, Jing Xiong   +4 more
doaj   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Identification of the Binding Domain for Secretory Phospholipases A2 on Their M-type 180-kDa Membrane Receptor [PDF]

Journal of Biological Chemistry, 1995
The rabbit muscle (M)-type receptor for secretory phospholipases A2 (sPLA2s) has a large extracellular domain of 1394 amino acids, composed of an N-terminal cysteine-rich domain, a fibronectin-like type II domain, and eight carbohydrate recognition domains (CRDs). It is thought to mediate some of the physiological effects of mammalian sPLA2s, including
J P, Nicolas, G, Lambeau, M, Lazdunski
openaire   +2 more sources

Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy [PDF]

, 2018
Anti-phospholipase A2 receptor antibody; Membranous nephropathy; Spontaneous remissionAnticòs del receptor anti-fosfolipasa A2; Nefropatia membranosa; Remissió espontàniaAnticuerpo del receptor anti-fosfolipasa A2; Nefropatía membranosa; Remisión ...
Agraz Pamplona, Irene, Soler Romeo, Maria Jose, Diaz, Montserrat, Díaz Encarnación, Montserrat Mercedes, Universitat Autònoma de Barcelona, Soler, María José   +5 more
core   +3 more sources

Clinical significance of the determination of antibodies to thrombospondin type 1 containing domain 7A (THSD7A) in membranous nephropathy

Терапевтический архив, 2023
Background. Membranous nephropathy (MN) is an immunocomplex glomerular disease, which is the most common cause of nephrotic syndrome in adults. Numerous studies have established that autoantibodies against the target podocyte autoantigens, including the ...
Patimat A. Kakhsurueva, Elena S. Kamyshova, Irina N. Bobkova, Ekaterina V. Stavrovskaya, Tatiana E. Rudenko, Elena Y. Andreeva   +5 more
doaj   +1 more source

Posttransplant membranous nephropathy - A case report

Indian Journal of Transplantation, 2022
Primary membranous nephropathy (PMN) is a common cause of adult-onset nephrotic syndrome. Anti-M-type phospholipase A2 receptor (PLA2R) antibodies are pathogenic and correlate with clinical outcomes. The role of anti-PLA2R in recurrent PMN is unclear. In
Shabna Sullaiman, Prabhat Chauhan, Ashwani Kumar, Ritambhra Nada, Ranjana Minz, Vinod Kumar, Ashish Sharma, Sarbpreet Singh, Vivek Kumar, Manish Rathi, Harbir Singh Kohli, Raja Ramachandran   +11 more
doaj   +1 more source

Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy

Chinese Medical Journal, 2014
Objective To highlight current knowledge about M-type phospholipase A2 receptor (PLA2R) which is the first human autoantigen discovered in adult idiopathic membranous nephropathy. Data sources Relevant articles published in English from 2000 to present were selected from PubMed ...
Chao, Wang, Huan, Lu, Cui, Yang, Yuezhong, Luo   +3 more
openaire   +2 more sources

Activation of Cytokine Production by Secreted Phospholipase A2 in Human Lung Macrophages Expressing the M-Type Receptor [PDF]

The Journal of Immunology, 2005
Abstract Secreted phospholipases A2 (sPLA2) are enzymes released in plasma and extracellular fluids during inflammatory diseases. Because human group IB and X sPLA2s are expressed in the lung, we examined their effects on primary human lung macrophages (HLM).
Granata, Francescopaolo, Petraroli, Angelica, Boilard, Eric, Bezzine, Sofiane, Bollinger, James, Del Vecchio, Luigi, Gelb, Michael H., Lambeau, Gerard, Marone, Gianni, TRIGGIANI, MASSIMO   +9 more
openaire   +4 more sources