Linchuang shenzangbing zazhi, 2021 The sensitivity of serum anti-M-type phospholipase A2 receptor antibodies（anti-PLA2 R Abs）is 70%～80% in idiopathic membranous nephropathy and the specificity over 95%.This article reviewed the latest research advances on the pathogenesis,diagnosis ...
Wang Hui +3 more
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sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. [PDF]
Sci Rep, 2014 The M-type phospholipase A2 receptor (PLA2R) is expressed in podocytes in human glomeruli. Group IB secretory phospholipase A2 (sPLA2 IB), which is one of the ligands of the PLA2R, is more highly expressed in chronic renal failure patients than in controls.
Pan Y +7 more
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MiR-130a-5p prevents angiotensin II-induced podocyte apoptosis by modulating M-type phospholipase A2 receptor. [PDF]
Cell Cycle, 2018 Podocyte apoptosis is considered as the important element that promotes the development and progress of membranous nephropathy (MN). Unfortunately, the underlying mechanism of podocytes apoptosis in MN remains elusive. We compared the renal expressions of miR-130a-5p and M-type phospholipase A2 receptor (PLA2R) between MN patients (n = 30) and 30 ...
Liu D +9 more
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Glomerular DiseasesPrimary membranous nephropathy is a common cause of adult-onset nephrotic syndrome, with an overall incidence of 12 cases per million per year.
Marco Prunotto +8 more
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Nefrología (English Edition), 2015 In membranous nephropathy, the presence of antibodies against M-type phospholipase A2 receptor is considered highly specific for idiopathic forms. However, no specific association to a particular clinical profile has been found for such antibodies ...
Elías Jatem Escalante +6 more
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M-type phospholipase A2 receptor autoantibodies and renal function in patients with primary membranous nephropathy. [PDF]
Clin J Am Soc Nephrol, 2014 Loss of renal function in patients with primary membranous nephropathy cannot be reliably predicted by laboratory or clinical markers at the time of diagnosis. M-type phospholipase A2 receptor autoantibodies have been shown to be associated with changes in proteinuria.
Hoxha E +4 more
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Diagnostic Usefulness of Antibodies Against M-type Phospholipase A2 Receptor (aPLA2R) in Primary Membranous Nephropathy in the Mexican Population. [PDF]
Cureus, 2023 This study aimed to determine the frequency and diagnostic performance of antibodies against M-type phospholipase A2 receptors (aPLA2R) in subjects with idiopathic membranous nephropathy (IMN).A diagnostic test study was conducted in a cohort of 160 patients from the nephrology outpatient clinic over a period of eight years.
Diaz Garcia JD.
europepmc +3 more sources
Utility of Determining Autoantibodies to M-type Phospholipase A2 Receptor in Diagnosing Primary Membranous Nephropathy: An Ideal Setting. [PDF]
Indian J Nephrol, 2017 Ramachandran R +8 more
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Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy. [PDF]
Bioengineered, 2021 Primary membranous nephropathy, also known as idiopathic membranous nephropathy, is an autoimmune disease. As an autoimmune disease, genetic factors are essential in the pathogenesis of IMN. People pay more and more attention to genetics and bioinformatics.
Liu X, Xu W, Yu C, Wang M, Liu R, Xie R.
europepmc +4 more sources
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. [PDF]
N Engl J Med, 2009 Idiopathic membranous nephropathy, a common form of the nephrotic syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis has been elusive because the target antigen is unknown.We performed Western blotting of protein extracts from normal human glomeruli with serum samples from patients with idiopathic or secondary ...
Beck LH +7 more
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