Results 11 to 20 of about 26,727 (247)

MiR-130a-5p prevents angiotensin II-induced podocyte apoptosis by modulating M-type phospholipase A2 receptor. [PDF]

Cell Cycle, 2018
Podocyte apoptosis is considered as the important element that promotes the development and progress of membranous nephropathy (MN). Unfortunately, the underlying mechanism of podocytes apoptosis in MN remains elusive. We compared the renal expressions of miR-130a-5p and M-type phospholipase A2 receptor (PLA2R) between MN patients (n = 30) and 30 ...
Liu D, Liu F, Wang X, Qiao Y, Pan S, Yang Y, Hu Y, Zhang Y, Tian F, Liu Z.   +9 more
europepmc   +5 more sources

Value of M-type phospholipase A2 receptor in clinical diagnosis and treatment of membranous nephropathy:recent advances and current controversies

Linchuang shenzangbing zazhi, 2021
The sensitivity of serum anti-M-type phospholipase A2 receptor antibodies（anti-PLA2 R Abs）is 70%～80% in idiopathic membranous nephropathy and the specificity over 95%.This article reviewed the latest research advances on the pathogenesis,diagnosis ...
Wang Hui, Jiang Man, Zhang Di, Wang Yu-qin   +3 more
doaj   +2 more sources

Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy. [PDF]

Bioengineered, 2021
Primary membranous nephropathy, also known as idiopathic membranous nephropathy, is an autoimmune disease. As an autoimmune disease, genetic factors are essential in the pathogenesis of IMN. People pay more and more attention to genetics and bioinformatics.
Liu X, Xu W, Yu C, Wang M, Liu R, Xie R.
europepmc   +4 more sources

M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. [PDF]

N Engl J Med, 2009
Idiopathic membranous nephropathy, a common form of the nephrotic syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis has been elusive because the target antigen is unknown.We performed Western blotting of protein extracts from normal human glomeruli with serum samples from patients with idiopathic or secondary ...
Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ.   +7 more
europepmc   +4 more sources

Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy [PDF]

Kidney International, 2012
The M-type phospholipase A2 receptor (PLA2R) is the major target antigen in idiopathic membranous nephropathy with detectable autoantibodies in the serum of up to 70% of patients. In retrospective studies, the PLA2R-autoantibody titer in the serum was sometimes negative indicating their measurement alone may be inconclusive.
Hoxha, Elion, Kneißler, Ursula, Stege, Gesa, Zahner, Gunther, Thiele, Ina, Panzer, Ulf, Harendza, Sigrid, Helmchen, Udo M., Stahl, Rolf A.K.   +8 more
openaire   +3 more sources

Activation of Cytokine Production by Secreted Phospholipase A2 in Human Lung Macrophages Expressing the M-Type Receptor [PDF]

The Journal of Immunology, 2005
Abstract Secreted phospholipases A2 (sPLA2) are enzymes released in plasma and extracellular fluids during inflammatory diseases. Because human group IB and X sPLA2s are expressed in the lung, we examined their effects on primary human lung macrophages (HLM).
Granata, Francescopaolo, Petraroli, Angelica, Boilard, Eric, Bezzine, Sofiane, Bollinger, James, Del Vecchio, Luigi, Gelb, Michael H., Lambeau, Gerard, Marone, Gianni, TRIGGIANI, MASSIMO   +9 more
openaire   +5 more sources

Utility of Determining Autoantibodies to M-type Phospholipase A2 Receptor in Diagnosing Primary Membranous Nephropathy: An Ideal Setting. [PDF]

Indian J Nephrol, 2017
Ramachandran R, Kumar V, Singh N, Kataruka M, Kumar V, Rathi M, Kohli HS, Jha V, Gupta KL.   +8 more
europepmc   +3 more sources

Spontaneous inferior epigastric artery hemorrhage in a COVID-19 patient with membranous nephropathy on anticoagulant therapy: a Case Report [PDF]

Frontiers in Medicine
BackgroundThe management of Coronavirus disease 2019 (COVID-19) is complicated by coagulopathies that increase both thrombotic and hemorrhagic risks, particularly in patients with comorbidities such as membranous nephropathy (MN) who require ...
Nianzong Hou, Nianzong Hou, Guoxiang Xu, Lin Wang, Yun Zhang, Yong Yu, Lin Zhu, Weiwei Song, Rumin Zhang, Kai Wang   +9 more
doaj   +2 more sources

PLA2R-IgG4 antibody as a predictive biomarker of treatment effectiveness and prognostic evaluation in patients with idiopathic membranous nephropathy: a retrospective study [PDF]

PeerJ, 2022
Background The Kidney Disease Improving Global Outcomes (KDIGO) 2021 guidelines recommend Rituximab (RTX) as the first-line therapy and phospholipase A2 receptor (PLA2R) antibody as a biomarker for remission and prognosis in patients with idiopathic ...
Yiqing Huang, Junyi Zhou, Kezhi Zhou, Biao Huang, Jing Xue, Xiran Zhang, Bin Liu, Zhijian Zhang, Leting Zhou, Ting Cai, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +13 more
doaj   +2 more sources

Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study

Acta Clinica Croatica, 2021
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB).
Mario Laganović, Ivica Horvatić, Ivan Bubić, Mario Ilić, Bojana Maksimović, Ana Kozmar, Ivana Vuković Brinar, Matija Crnogorac, Marijana Živko, Margareta Fištrek, Željka Jureković, Danica Galešić Ljubanović, Marijana Ćorić, Stela Bulimbašić, Krešimir Galešić, Mladen Knotek   +15 more
doaj   +1 more source