Results 11 to 20 of about 3,877 (197)

PLA2R antibody, PLA2R rs4664308 polymorphism and PLA2R mRNA levels in Tunisian patients with primary membranous nephritis

PLoS ONE, 2020
Background Primary membranous nephritis (PMN) is an autoimmune disease induced by the deposit of antibodies (Ab) to the phospholipase receptor A2 receptor (PLA2R) on podocytes.
Tarak Dhaouadi, Jihen Abdellatif, Raja Trabelsi, Hanene Gaied, Sameh Chamkhi, Imen Sfar, Rym Goucha, Fethi Ben Hamida, Taieb Ben Abdallah, Yousr Gorgi, Giuseppe Remuzzi   +10 more
doaj   +7 more sources

Prognostic value of PLA2R autoimmunity detected by measurement of anti-PLA2R antibodies combined with detection of PLA2R antigen in membranous nephropathy: A single-centre study over 14 years. [PDF]

PLoS ONE, 2017
INTRODUCTION:Clinical course of membranous nephropathy (MN) is difficult to predict. Measurement of circulating anti-PLA2R autoantibodies (PLA2R-Ab) and detection in immune deposits of PLA2R antigen (PLA2R-Ag) are major advances in disease understanding.
Franck Pourcine, Karine Dahan, Fabrice Mihout, Marine Cachanado, Isabelle Brocheriou, Hanna Debiec, Pierre Ronco   +6 more
doaj   +6 more sources

Anti-Phospholipase A2 Receptor (PLA2R) Antibody and Glomerular PLA2R Expression in Japanese Patients with Membranous Nephropathy.

PLoS ONE, 2016
The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay systems for anti-PLA2R antibody (Ab) have been developed.
Kei Hihara, Masayuki Iyoda, Shohei Tachibana, Ken Iseri, Tomohiro Saito, Yasutaka Yamamoto, Taihei Suzuki, Yukihiro Wada, Kei Matsumoto, Takanori Shibata   +9 more
doaj   +5 more sources

The value of PLA2R antigen and IgG subclass staining relative to anti-PLA2R seropositivity in the differential diagnosis of membranous nephropathy [PDF]

BMC Nephrology, 2023
Background The diagnostic performance of PLA2R and IgG subclass staining of kidney biopsies relative to anti-PLA2R seropositivity in the differentiation of primary and secondary membranous nephropathy (pMN, sMN) was examined.
Dóra Bajcsi, László Bitó, Sándor Turkevi-Nagy, Tibor Nyári, Éva Kemény, Péter Légrády, György Ábrahám, Béla Iványi   +7 more
doaj   +7 more sources

Anti-PLA2R Antibodies as a Prognostic Factor in PLA2R-Related Membranous Nephropathy [PDF]

American Journal of Nephrology, 2015
<b><i>Background:</i></b> The natural course of idiopathic membranous nephropathy (MN) varies, as it is known through favorable outcomes in most patients. However, one third of patients with idiopathic MN will slowly progress to end-stage renal disease (ESRD). To prevent disease progression, patients at high risk to develop ESRD
Timmermans, Sjoerd A. M. E. G., Hamid, Myrurgia A. Abdul, Tervaert, Jan Willem Cohen, Damoiseaux, Jan G. M. C., van Paassen, Pieter   +4 more
core   +6 more sources

Phospholipase A2 receptor (PLA2R) related membranous nephropathy - not specific for idiopathic cases any more [PDF]

Journal of Nephropathology, 2018
Context: Membranous nephropathy is among the most common causes of nephrotic syndrome in adults. Evidence Acquisitions: PubMed, EBSCO, Web of Science, directory of open access journals (DOAJ), EMBASE, and Google Scholar with keywords of phospholipase A2 ...
Bahar Bastani
doaj   +3 more sources

PLA2R binds to the annexin A2-S100A10 complex in human podocytes

Scientific Reports, 2017
Phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family found in podocytes in human kidney. PLA2R is the target of the autoimmune disease, membranous nephropathy, characterised by production of anti-PLA2R autoantibodies which bind to
Maryline Fresquet, Thomas A. Jowitt, Edward A. McKenzie, Matthew D. Ball, Michael J. Randles, Rachel Lennon, Paul E. Brenchley   +6 more
doaj   +2 more sources

The application of podocyte antigen PLA2R and anti-PLA2R antibody in the diagnosis and treatment of membranous nephropathy

Renal Failure, 2023
The application of podocyte antigen M-type phospholipase A2 receptor (PLA2R, GAg) and serum anti-PLA2R antibody (SAb) in predicting the prognosis of membrane nephropathy (MN) was controversial. 328 biopsy-proven MN patients were divided into three phenotypes, 182 MN patients with GAg+/SAb+, 118 MN patients with GAg+/SAb-, and 28 MN patients with GAg ...
Yang Chen, Ying Xu, Siyu Chen, Yedong Yu, Xueling Zhu, Jianghua Chen   +5 more
openaire   +4 more sources

Clinical value of a serum anti-PLA2R antibody in the diagnosis and monitoring of primary membranous nephropathy in adults

International Journal of Nephrology and Renovascular Disease, 2018
Xueping Wu,1 Lei Liu,1 Yaling Guo,1 Lijuan Yang2 1Department of Nephrology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, People’s Republic of China; 2Department of Physiology, Bengbu Medical College, Bengbu, Anhui, People&
Wu X, Liu L, Guo Y, Yang L
doaj   +1 more source

Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies

Renal Failure
Idiopathic membranous nephropathy (IMN) with deposits of phospholipase A2 receptor (PLA2R) antigen in glomerular tissue (GAg+) but no circulating serum PLA2R antibody (SAb-) has been reported. However, little is known about the clinicopathological characteristics and prognosis of this subtype.A total of 74 IMN patients with GAg + identified by kidney ...
Xue Li, Yang Shen, Yanchun Li, Lijie Ma, Qianmei Sun   +4 more
core   +5 more sources