Results 21 to 30 of about 3,877 (197)

Clinical Features and Pathology of PLA2R and THSD7A-Associated Membranous Nephropathy: A Single-Center Study from China [PDF]

ImmunoTargets and Therapy
Yan Pan, Wei Dong Chen, Lei Liu, Huijuan Yang, Baochao Chang, Caixia Cui Department of Nephrology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui Province, People’s Republic of ChinaCorrespondence: Wei Dong Chen, Email cwd2012@163 ...
Pan Y, Chen WD, Liu L, Yang H, Chang B, Cui C   +5 more
doaj   +1 more source

The significance of anti-PLA2R antibody in the diagnosis and treatment of primary membranous nephropathy

Linchuang shenzangbing zazhi, 2019
Primary membranous nephropathy(PMN) is a glomerulus-specific autoimmune disorder mainly caused by challenge of autoantibodies against the recently discovered antigens located on podocytes, such as the M-type phospholipase A2 receptor(PLA2R), the ...
XU Dong-mei, LIU Yi-peng
doaj   +1 more source

Predictive value of the domain specific PLA2R antibodies for clinical remission in patients with primary membranous nephropathy: A retrospective study. [PDF]

PLoS ONE
BackgroundM-type phospholipase A2 receptor (PLA2R) is a major auto-antigen of primary membranous nephropathy(PMN). Anti-PLA2R antibody levels are closely associated with disease severity and therapeutic effectiveness.
Kezhi Zhou, Junyi Zhou, Leting Zhou, Jing Xue, Bin Liu, Zhijian Zhang, Xiran Zhang, Ting Cai, Sijia Shao, Biao Huang, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +13 more
doaj   +2 more sources

PLA2R-IgG4 antibody as a predictive biomarker of treatment effectiveness and prognostic evaluation in patients with idiopathic membranous nephropathy: a retrospective study [PDF]

PeerJ, 2022
Background The Kidney Disease Improving Global Outcomes (KDIGO) 2021 guidelines recommend Rituximab (RTX) as the first-line therapy and phospholipase A2 receptor (PLA2R) antibody as a biomarker for remission and prognosis in patients with idiopathic ...
Yiqing Huang, Junyi Zhou, Kezhi Zhou, Biao Huang, Jing Xue, Xiran Zhang, Bin Liu, Zhijian Zhang, Leting Zhou, Ting Cai, Yi Zhang, Zhigang Hu, Liang Wang, Xiaobin Liu   +13 more
doaj   +2 more sources

Distinct Complement Activation Profiles Between NELL1‐ and PLA2R‐Associated Membranous Nephropathy: A Clinicopathological and Proteomic Study [PDF]

Nephrology (Carlton)
We compared the clinicopathological features and complement activation profiles of PLA2R‐associated and NELL1‐associated membranous nephropathy. NELL1‐associated membranous nephropathy was associated with older age, more chronic histologic changes and less glomerular C3 and C4d deposition.
Suzuki T, Dedong K, Kawanishi K, Ueda M, Kajio Y, Kobayashi K, Kanazawa N, Takahashi‐Kobayashi M, Usui J, Baba M, Honda H, Honda K, Iyoda M.   +12 more
europepmc   +2 more sources

PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy [PDF]

BMC Nephrology, 2016
The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis.A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled.
Ge, Yong-Chun, Jin, Bo, Zeng, Cai-Hong, Zhang, Ming-Chao, Chen, Da-Cheng, Yin, Ru, Le, Wei-Bo   +6 more
openaire   +2 more sources

Seropositive PLA2R-associated membranous nephropathy but biopsy-negative PLA2R staining

Nephrology Dialysis Transplantation, 2020
Abstract Background Serum phospholipase A2 receptor (PLA2R) antibody (SAb) and glomerular deposits of PLA2R antigen (GAg) have been tested widely in idiopathic membranous nephropathy (MN). Recently, we noticed a special form of PLA2R-associated MN with positive circulating PLA2R antibody but negative ...
Jiao Luo, Wang Zhang, Cailing Su, Zhanmei Zhou, Guobao Wang   +4 more
openaire   +2 more sources

The characters of antibodies against PLA2R in healthy individuals and in the patient with PLA2R associated membranous nephropathy

European Journal of Medical Research, 2023
Abstract Background Most primary membranous nephropathy (MN) is mediated by anti-phospholipase A2 receptor (PLA2R) antibodies. Recently, these antibodies have been revealed months to years before the disease's onset. Their production and pathogenicity need further investigation. Methods
Yan-jiao Cheng, Miao Wang, Jia Wang, Zhao Cui, Ming-hui Zhao   +4 more
openaire   +3 more sources

PLA2R-Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report. [PDF]

Clin Case Rep
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Abreham B, Hamza L, Kebede A, Bekele DR, Amdemariam Z.   +4 more
europepmc   +2 more sources

The Role of Renal PLA2R Staining Combined with Serum PLA2R Antibody in Membranous Nephropathy Risk Stratification

Journal of Clinical Medicine, 2023
Background: This study aimed to examine the clinicopathological profiles and prognosis of membranous nephropathy in different subtypes classified by serum PLA2R antibody (SAb) and glomerular PLA2R antigen staining (GAg). Methods: A total of 372 biopsy-proven membranous nephropathy (MN) cases, unrelated to lupus, with urine protein > 2 g/24 h and ...
Hu, Xiaofan, Wang, Xinlu, Yu, Xialian, Ni, Liyan, Gao, Chenni, Pan, Xiaoxia, Ren, Hong, Xu, Jing, Ma, Jun   +8 more
openaire   +2 more sources