Results 41 to 50 of about 3,877 (197)
Терапевтический архив, 2023 Background. Membranous nephropathy (MN) is an immunocomplex glomerular disease, which is the most common cause of nephrotic syndrome in adults. Numerous studies have established that autoantibodies against the target podocyte autoantigens, including the ...
Patimat A. Kakhsurueva +5 more
doaj +1 more source
Kidney Research and Clinical Practice, 2018 Background: Phospholipase A2 receptor (PLA2R) has been identified as a major autoantigen in primary membranous nephropathy (MN). We evaluated the association between anti-PLA2R antibodies and clinical outcome in Korean patients with primary MN.
Eun Joo Song +9 more
doaj +1 more source
Modern view on the complement system role in membranous nephropathy
Терапевтический архив, 2022 Membranous nephropathy (MN), an immune-mediated glomerular disease, is the most common cause of adult nephrotic syndrome. In MN, proteinuria is developed by podocyte damage due to the complement system activation in response to the subepithelial ...
Elena S. Kamyshova +2 more
doaj +1 more source
The Role of PLA2R Antibody in Treatment of Membranous Nephropathy [PDF]
Kidney International Reports, 2018 Membranous nephropathy (MN) is one of the leading causes of nephrotic syndrome in adults. Some cases are associated with malignancy, infections, autoimmune systemic diseases, or drugs, but most are of an autoimmune nature, being referred to as primary (PMN).1 The natural course is variable and unpredictable: approximately one-third of patients with PMN
Dahan, Karine +4 more
openaire +4 more sources
Frontiers in Immunology, 2020 Aims: To develop a highly sensitive immunoassay for PLA2R autoantibodies and study the relationship between PLA2R autoantibodies and autoimmune thyroid disease-associated nephropathy.Methods: We applied a highly sensitive time-resolved fluoroimmunoassay ...
Biao Huang +10 more
doaj +1 more source
Tacrolimus Prevents TWEAK-Induced PLA2R Expression in Cultured Human Podocytes [PDF]
, 2020 Primary membranous nephropathy is usually caused by antibodies against the podocyte antigen membrane M-type phospholipase A2 receptor (PLA2R). The treatment of membranous nephropathy is not fully satisfactory. The calcineurin inhibitor tacrolimus is used
Valiño-Rivas, Lara +18 more
core +1 more source
Management of Membranous Nephropathy in the PLA2R Era [PDF]
Clinical Journal of the American Society of Nephrology, 2017 Membranous nephropathy (MN) occurs when circulating antibodies permeate the glomerular basement membrane and in the subepithelial space, form immune complexes with epitopes on podocyte membranes.
openaire +2 more sources
Comparison of patients with PLA2R-related and PLA2R-unrelated PMN.
, 2017 Comparison of patients with PLA2R-related and PLA2R-unrelated PMN.
Isabelle Brocheriou (3812980) +6 more
core +1 more source
BMC Nephrology, 2019 Objective To investigate the correlation of M-type phospholipase A2 receptor (PLA2R) expression and serum anti-PLA2R antibody with the clinical parameters and prognosis of patients with idiopathic membranous nephropathy (IMN). Methods A literature search
Dan Dong +5 more
doaj +1 more source
, 2016 Comparison of the prevalence of serum anti-PLA2R Abs with glomerular PLA2R Ag expression in IMN patients.
Tomohiro Saito (659385) +9 more
core +1 more source