Results 41 to 50 of about 2,806 (128)

Diagnostic Complexity in Differentiating Between Primary and Secondary Anti‐PLA2R–Positive Membranous Nephropathy in a Patient With Laryngeal Squamous Cell Carcinoma

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Introduction The association between membranous nephropathy (MN) and malignant neoplasms has been extensively studied in recent decades and is well established in the literature. Although PLA2R is the main target antigen in primary MN, there remain uncertainties regarding a possible connection between malignancy and anti‐PLA2R positivity.
Fabiano Bichuette Custodio, Laura Penna Rocha, Luciana Botta Ribeiro, Marlene Antônia dos Reis, Juliana Reis Machado, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

The Spectrum and Temporal Trends of Glomerular Diseases in Saudi Arabia: A Systematic Review of Biopsy‐Based Studies

International Journal of Nephrology, Volume 2026, Issue 1, 2026.
Purpose This systematic review aims to synthesize data from biopsy‐based studies to quantify the epidemiology, regional variations, and temporal trends of glomerular diseases (GDs) in Saudi Arabia. Methods We conducted a systematic search using PubMed, MEDLINE, the Cochrane Library, and Google Scholar to identify relevant studies published up to ...
Manal E. Alotaibi, Laila A. Alharbi, Fahd Almalki, Waleed Alotaibi, Ibrahim Tawhari, Mutlaq Alotaibi, Harleen Khatra   +6 more
wiley   +1 more source

Phospholipase A2 Receptor Antibodies and Clinical Prognosis in Patients with Idiopathic Membranous Nephropathy: An Updated Systematic Review and Meta-Analysis

Kidney & Blood Pressure Research, 2023
Background: Idiopathic membranous nephropathy (IMN) is the most common form of primary nephrotic syndrome in adults. Antibodies against the M-type phospholipase A2 receptor (PLA2R-ab) are considered as diagnostic biomarkers of IMN.
Jialing Zhang, Zhengjia Fan, Peixin Wang, Ai-Hua Zhang   +3 more
doaj   +1 more source

HLA Profiles of Patients With Chronic Kidney Disease in Central South Africa

International Journal of Nephrology, Volume 2026, Issue 1, 2026.
Background The human leucocyte antigen (HLA) complex has been associated with the susceptibility of several hundred human diseases, increasingly so with kidney disease. HLA data are under‐represented in South Africa, and thus, their contribution to disease characterisation remains poorly understood.
Walter Janse van Rensburg, Kirsten Lange, Feziwe Bisiwe, Jean Kloppers, Srijoni Sengupta   +4 more
wiley   +1 more source

Modified Guizhi Plus Huangqi Decoction Improves Antiphospholipase A2 Receptor Antibody–Induced Podocyte Injury Through Modulating Autophagy‐Related Markers via AMPK/mTOR Pathway

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) is a primary cause of nephrotic syndrome in adults. Modified Guizhi plus Huangqi decoction (MGPHD) has been clinically effective for PLA2R MN. This basic study was designed to investigate the efficacy and mechanisms of MGPHD in treating PLA2R MN.
Manxia Huang, Yangpu Li, Zhishu Yang, Yunxin Lin, Zhuoting Liu, Zilan Jiang, Tingting Tan, Xinhui Liu, Youjia Zeng, Yue Xu   +9 more
wiley   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, Volume 9, Issue 9, September 2025.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Time-resolved fluoroimmunoassay improves sensitivity in the diagnosis of primary membranous nephropathy with low phospholipase A2 receptor antibody titer

Scientific Reports
To evaluate the diagnostic utility of time-resolved fluoroimmunoassay (TRFIA) for detecting serum anti-Phospholipase A2 Receptor (PLA2R) antibodies, specifically the IgG (PLA2R-IgG) and IgG4 subclass (PLA2R-IgG4).
Zhenling Deng, Yuanlin Qu, Yuting Liu, Tianyu Zheng, Yueming Gao, Biao Huang, Yue Wang, Danxia Zheng   +7 more
doaj   +1 more source

Serum phospholipase A2 receptor antibody is associated with thrombogenesis in patients with idiopathic membranous nephropathy

Kidney & Blood Pressure Research
Introduction: Patients with idiopathic membranous nephropathy (IMN) are particularly susceptible to thromboembolism (TE). The phospholipase A2 receptor (PLA2R) antibody (Ab) has been indicated to work as an independent risk predictor for venous TE in IMN.
Qinling Zhang, Guiling Liu
doaj   +1 more source

CARI Guidelines Commentary on the KDIGO Clinical Practice Guideline for the Management of Glomerular Diseases

Nephrology, Volume 30, Issue 9, September 2025.
ABSTRACT Aim The KDIGO 2021 Glomerular Disease Guidelines provide updated recommendations on the management of glomerular diseases (GD), with substantial advances made in diagnosis, treatment, and improvement of outcomes for people with GD. Methods The Caring for Australians and New Zealanders with kidney Impairment (CARI) Guidelines commentary ...
Bhadran Bose, Simon A. Carter, Mia E. Abdy, Nicole Scholes‐Robertson, Ieyesha Roberts, Tze Liang Goh, Vincent Lee, Emily See, Helen Coolican, Vanessa Cullen, Min Jun, Rathika Krishnasamy, Kelly Lambert, Jonathan Craig, Casey Light, Thu Nguyen, Carla Scuderi, David J. Tunnicliffe, Andrea K. Viecelli, Vincent Lee, Emily See, Helen Coolican, Vanessa Cullen, Min Jun, Kelly Lambert, Jonathan Craig, Casey Light, Thu Nguyen, Carla Scuderi   +28 more
wiley   +1 more source

Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. [PDF]

PLoS ONE, 2015
Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), which mainly belong to the IgG4 subclass, were ...
Takamasa Iwakura, Naro Ohashi, Akihiko Kato, Satoshi Baba, Hideo Yasuda   +4 more
doaj   +1 more source