Results 61 to 70 of about 3,430 (196)

Association of serum mannose-binding lectin, anti-phospholipase A2 receptor antibody and renal outcomes in idiopathic membranous nephropathy and atypical membranous nephropathy: a single center retrospective cohort study

Renal Failure, 2022
Objectives Idiopathic membranous nephropathy (iMN) is a major cause of nephrotic syndrome. Atypical membranous nephropathy (aMN) is a new type of nephropathy in China, characterized by a ‘full-house’ on immunofluorescent examination, that is IgG, IgA ...
Yuchao Zhao, Meishun Cai, Zhenbin Jiang, Bao Dong, Yu Yan, Yina Wang, Li Zuo   +6 more
doaj   +1 more source

Diagnostic Complexity in Differentiating Between Primary and Secondary Anti‐PLA2R–Positive Membranous Nephropathy in a Patient With Laryngeal Squamous Cell Carcinoma

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Introduction The association between membranous nephropathy (MN) and malignant neoplasms has been extensively studied in recent decades and is well established in the literature. Although PLA2R is the main target antigen in primary MN, there remain uncertainties regarding a possible connection between malignancy and anti‐PLA2R positivity.
Fabiano Bichuette Custodio, Laura Penna Rocha, Luciana Botta Ribeiro, Marlene Antônia dos Reis, Juliana Reis Machado, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

The Spectrum and Temporal Trends of Glomerular Diseases in Saudi Arabia: A Systematic Review of Biopsy‐Based Studies

International Journal of Nephrology, Volume 2026, Issue 1, 2026.
Purpose This systematic review aims to synthesize data from biopsy‐based studies to quantify the epidemiology, regional variations, and temporal trends of glomerular diseases (GDs) in Saudi Arabia. Methods We conducted a systematic search using PubMed, MEDLINE, the Cochrane Library, and Google Scholar to identify relevant studies published up to ...
Manal E. Alotaibi, Laila A. Alharbi, Fahd Almalki, Waleed Alotaibi, Ibrahim Tawhari, Mutlaq Alotaibi, Harleen Khatra   +6 more
wiley   +1 more source

Current research status of PLA2R and malignancy associated membranous nephropathy

, 2021
As a common cause of nephropathy syndrome in adults, membranous nephropathy（MN）often leads to end-stage renal disease.PLA2R related testing may aid a definite diagnosis of idiopathic MN.In recent years, we have detected some patients of malignancy ...
Wang Yan-qiu, Zhu Wan-ting
core  

Phospholipase A2 Receptor Antibodies and Clinical Prognosis in Patients with Idiopathic Membranous Nephropathy: An Updated Systematic Review and Meta-Analysis

Kidney & Blood Pressure Research, 2023
Background: Idiopathic membranous nephropathy (IMN) is the most common form of primary nephrotic syndrome in adults. Antibodies against the M-type phospholipase A2 receptor (PLA2R-ab) are considered as diagnostic biomarkers of IMN.
Jialing Zhang, Zhengjia Fan, Peixin Wang, Ai-Hua Zhang   +3 more
doaj   +1 more source

HLA Profiles of Patients With Chronic Kidney Disease in Central South Africa

International Journal of Nephrology, Volume 2026, Issue 1, 2026.
Background The human leucocyte antigen (HLA) complex has been associated with the susceptibility of several hundred human diseases, increasingly so with kidney disease. HLA data are under‐represented in South Africa, and thus, their contribution to disease characterisation remains poorly understood.
Walter Janse van Rensburg, Kirsten Lange, Feziwe Bisiwe, Jean Kloppers, Srijoni Sengupta   +4 more
wiley   +1 more source

Rapamycin attenuates PLA2R activation-mediated podocyte apoptosis via the PI3K/AKT/mTOR pathway [PDF]

, 2021
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults without diabetes. Primary MN has been associated with circulating antibodies against native podocyte antigens, including phospholipase A2 receptor (PLA2R); however ...
Hsiang-Hao Hsu, Chen, Jin-Bor, Terry Ting-Yu Chiou, Wen-Chin Lee, Chau, You-Ying, Hsu, Hsiang-Hao, Lee, Wen-Chin, Huang, Shao-Pei, Chioua, Terry Ting-Yu, You-Ying Chau, Jin-Bor Chen, Shao-Pei Hung   +11 more
core   +1 more source

Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients with membranous nephropathy

Medicine, 2017
M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated the diagnostic value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R antibody and glomerular PLA2R deposition, and their association with clinical characteristics need to be further ...
Pang, Lu, Zhang, Ai-Min, Li, Hai-Xia, Du, Jia-Lin, Jiao, Li-Li, Duan, Nan, Liu, Yi, Yu, Dan   +7 more
openaire   +2 more sources

Modified Guizhi Plus Huangqi Decoction Improves Antiphospholipase A2 Receptor Antibody–Induced Podocyte Injury Through Modulating Autophagy‐Related Markers via AMPK/mTOR Pathway

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) is a primary cause of nephrotic syndrome in adults. Modified Guizhi plus Huangqi decoction (MGPHD) has been clinically effective for PLA2R MN. This basic study was designed to investigate the efficacy and mechanisms of MGPHD in treating PLA2R MN.
Manxia Huang, Yangpu Li, Zhishu Yang, Yunxin Lin, Zhuoting Liu, Zilan Jiang, Tingting Tan, Xinhui Liu, Youjia Zeng, Yue Xu   +9 more
wiley   +1 more source

Glomerulonephrite extramembraneuse anti-PLA2R+: 39 ans d’activite sans insuffisance renale!

, 2019
Objectif: Rapporter un cas de Glomérulonéphrite extra membraneuse anti-PLA2R+ évoluant depuis 39 ans, sans insuffisance rénale. Observation : Le diagnostic histologique de syndrome néphrotique à lésions glomérulaires minimes fut posé en 1980 chez une ...
Djibril, M.A., Tsevi, Y.M., Aydin, S, Jadoul, M, Djagadou, K.A., Nemi, K.D.   +5 more
core   +1 more source