Results 61 to 70 of about 3,877 (197)

Supplementary Material for: Anti-PLA2R Antibodies as a Prognostic Factor in PLA2R-Related Membranous Nephropathy

, 2017
Background: The natural course of idiopathic membranous nephropathy (MN) varies, as it is known through favorable outcomes in most patients. However, one third of patients with idiopathic MN will slowly progress to end-stage renal disease (ESRD).
Timmermans S.A.M.E.G. (3683929), van Paassen P. (3683938), on behalf of the Limburg Renal Registry (3683935), Cohen Tervaert J.W. (3683932), Abdul Hamid M.A. (3683926), Damoiseaux J.G.M.C. (3683923)   +5 more
core   +1 more source

Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients with membranous nephropathy

Medicine, 2017
M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated the diagnostic value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R antibody and glomerular PLA2R deposition, and their association with clinical characteristics need to be further ...
Pang, Lu, Zhang, Ai-Min, Li, Hai-Xia, Du, Jia-Lin, Jiao, Li-Li, Duan, Nan, Liu, Yi, Yu, Dan   +7 more
openaire   +2 more sources

Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy.

, 2014
Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human ...
Gummadova, Jennet, McKenzie, Edward A, Brenchley, Paul E; id_orcid, Jowitt, Thomas A; id_orcid, Fresquet, Maryline; id_orcid, Lennon, Rachel; id_orcid, O'Cualain, Ronan, Collins, Richard   +7 more
core   +1 more source

Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro

Renal Failure, 2022
Background The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction.
Yanfen Li, Juntao Yu, Miao Wang, Zhao Cui, Ming-hui Zhao   +4 more
doaj   +1 more source

The Spectrum of Biopsy‐Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study

AGING MEDICINE, Volume 9, Issue 3, Page 258-264, June 2026.
This 20‐year retrospective study reveals a significant increase in renal biopsy utilization and a pivotal shift in biopsy‐proven renal disease among Chinese elderly patients. Secondary glomerular nephropathy (particularly diabetic nephropathy and hypertensive nephropathy) has surpassed primary glomerular nephropathy as the leading biopsy‐proven ...
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin Liu   +4 more
wiley   +1 more source

Monitoring anti-PLA2R antibody titres to predict the likelihood of spontaneous remission of membranous nephropathy [PDF]

, 2021
Anticossos anti-PLA2R; Nefropatia membranosa; PrediccióAnticuerpos anti-PLA2R; Nefropatía membranosa; PredicciónAnti-PLA2R antibodies; Membranous nephropathy; PredictionBackground In anti-phospholipase A2 receptor (PLA2R) membranous nephropathy (MN ...
Gràcia-Lavedan, Esther, Gonzalez, Jorge, Colàs-Campàs, Laura, Benítez, Ivan D., Jatem-Escalante, Elias, Segarra Medrano, Alfons, Martín-Conde, María Luisa, Laura Colás, María Luisa Martín-Conde, Elias Jatem-Escalante, Alfons Segarra-Medrano, Ivan D Benítez, Alicia Garcia-Carrasco, Esther Gràcia-Lavedan, Cristina Martínez, Jorge Gonzalez   +15 more
core   +1 more source

An anti-phospholipase A2 receptor quantitative immunoassay and epitope analysis in membranous nephropathy reveals different antigenic domains of the receptor. [PDF]

PLoS ONE, 2013
The phospholipase A2 receptor (PLA2R) was recently discovered as a target autoantigen in patients with idiopathic membranous nephropathy (IMN). Published evidence suggests that the autoantibodies directed towards a conformation dependent epitope are ...
Astrid Behnert, Marvin J Fritzler, Beina Teng, Meifeng Zhang, Frank Bollig, Hermann Haller, Andrej Skoberne, Michael Mahler, Mario Schiffer   +8 more
doaj   +1 more source

Outcome of patients with PLA2R-related PMN.

, 2017
Outcome of patients with PLA2R-related PMN.
Isabelle Brocheriou (3812980), Franck Pourcine (3812968), Marine Cachanado (3812983), Fabrice Mihout (3812971), Karine Dahan (3812974), Pierre Ronco (534582), Hanna Debiec (3812977)   +6 more
core   +1 more source

Clinical phenotype predicts anti-PLA2R serology in nephrotic range proteinuria

Nefrología
Background: The 2021 KDIGO guidelines permit non-invasive diagnosis of membranous nephropathy using anti-PLA2R antibodies in patients with nephrotic syndrome.
Asil Demirezen, Nuri Alperen Malkoç, Veysel Baran Tomar, Taha Enes Çetin, Ömer Faruk Akçay, Sena Türkmen, Özlem Gülbahar, Betül Öğüt, İpek Işık Gönül, Galip Güz, Ülver Derici, Yasemin Erten, Kadriye Altok, Özant Helvacı   +13 more
doaj   +3 more sources

Time-resolved fluoroimmunoassay improves sensitivity in the diagnosis of primary membranous nephropathy with low phospholipase A2 receptor antibody titer

Scientific Reports
To evaluate the diagnostic utility of time-resolved fluoroimmunoassay (TRFIA) for detecting serum anti-Phospholipase A2 Receptor (PLA2R) antibodies, specifically the IgG (PLA2R-IgG) and IgG4 subclass (PLA2R-IgG4).
Zhenling Deng, Yuanlin Qu, Yuting Liu, Tianyu Zheng, Yueming Gao, Biao Huang, Yue Wang, Danxia Zheng   +7 more
doaj   +1 more source