Results 51 to 60 of about 3,877 (197)

Urine PLA2R Antibody Detection in Hazard Stratification of PLA2R-Associated Membranous Nephropathy

Archives of Pathology & Laboratory Medicine
Context.— M-type phospholipase A2 receptor (PLA2R) is the major autoantigen of membranous nephropathy (MN). As the specific antibodies of MN, the correlation between serum PLA2R antibody (sPLA2R-Ab) levels and PLA2R-associated MN (PMN) risk stratification is still controversial.
Tianyu, Zheng, Yuan, Qin, Xuanli, Tang, Peng, Bi, Xuxiang, Hui, Zixuan, Zhou, Yulin, Fu, Huiming, Sheng, Xiumei, Zhou, Xueqin, Zhao, Yuanyuan, Du, Qiang, He, Biao, Huang   +12 more
openaire   +2 more sources

Malignancy-Associated Membranous Nephropathy with Positive Anti-PLA2R Autoantibodies: Coincidence or Connection

Case Reports in Nephrology and Dialysis, 2021
Membranous nephropathy (MN) is currently classified as either primary – often associated with positive anti-phospholipase-A2 receptor (PLA2R) autoantibodies – or as secondary – associated with malignancy, infection, medications, or autoimmune disease. We
Lyle W. Baker, Jaime Jimenez-Lopez, Xochiquetzal J. Geiger, Nabeel Aslam   +3 more
doaj   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Association of The Autoantibodies to M-Type Phospholipase A2 Receptor Titer with Clinical Characteristics and Outcome of Patients with Primary Membranous Nephropathy – 5-Year Follow up Study

Acta Clinica Croatica, 2021
Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB).
Mario Laganović, Ivica Horvatić, Ivan Bubić, Mario Ilić, Bojana Maksimović, Ana Kozmar, Ivana Vuković Brinar, Matija Crnogorac, Marijana Živko, Margareta Fištrek, Željka Jureković, Danica Galešić Ljubanović, Marijana Ćorić, Stela Bulimbašić, Krešimir Galešić, Mladen Knotek   +15 more
doaj   +1 more source

Arachidonic Acid Disrupts PKM2‐Linked Glycolysis‐Related Metabolism and Exacerbates PAN‐Induced Podocyte Injury

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Minimal change disease (MCD) frequently relapses, and infection is one of the most common clinical triggers. Arachidonic acid (AA), an inflammatory lipid mediator released during tissue injury and infection, has been implicated in podocyte injury, but its contribution to metabolic dysfunction in MCD remains unclear.
Kun Nie, Xiaowei Gao, Minggang Liu, Danyu You, Mengjie Weng, Tingting Zheng, Jiaqun Lin, Siyi Rao, Yongjie Zhuo, Jianxin Wan, Liyan Yang   +10 more
wiley   +1 more source

Correlation and discrepancy of phospholipase A2 receptor staining in membranous nephropathy in paraffin-embedded kidney biopsies

Saudi Journal of Kidney Diseases and Transplantation, 2018
Distinguishing primary from secondary forms of membranous nephropathy (MN) in paraffin-embedded kidney biopsies is challenging. Previous studies have measured the accuracy, sensitivity, and specificity of phospholipase A2 receptor (PLA2R) on MN. However,
Nasar Yousuf Alwahaibi, Umayma Yahya Alrawahi, Marwa Abdullah Alriyami   +2 more
doaj   +1 more source

Clinical usefulness of anti-M-type phospholipase-A-receptor antibodies in patients with membranous nephropathy and the comparison of three quantification methods

Immunological Medicine, 2020
Associations between anti-M-type phospholipase A2 receptor (PLA2R) antibodies and disease activity and prognosis have been suggested in primary membranous nephropathy (MN); however, more evidence is needed.
Yasuhiro Katsumata, Yuko Okamoto, Takahito Moriyama, Rina Moriyama, Manabu Kawamoto, Masanori Hanaoka, Keiko Uchida, Kosaku Nitta, Masayoshi Harigai   +8 more
doaj   +1 more source

Persistent Haematuria Is Associated With Reduced Kidney Survival in Primary Podocytopathies

Nephrology, Volume 31, Issue 8, August 2026.
ABSTRACT Aim Haematuria is frequently present in podocytopathies, but its significance and prognostic value are not well described. This study aimed to determine the prevalence and association between persistent haematuria and kidney survival in patients with membranous nephropathy (MN), minimal change disease (MCD) and focal segmental ...
Gabriel Ștefan, Nicoleta Petre, Adrian Zugravu, Simona Stancu   +3 more
wiley   +1 more source

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, Volume 13, Issue 40, 17 July 2026.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source