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Integrative Machine Learning Model for Overall Survival Prediction in Breast Cancer Using Clinical and Transcriptomic Data. [PDF]
Biology (Basel)Kivrak M +3 more
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THSD7A expression in human cancer
Genes Chromosomes and Cancer, 2017AbstractWe recently described a case of a Thrombospondin Type‐1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A‐positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different ...
Phillip R Stahl +2 more
exaly +3 more sources
Treatment of Membranous Nephropathy in Patients With THSD7A Antibodies Using Immunoadsorption
American Journal of Kidney Diseases, 2019Antibodies against THSD7A (thrombospondin type 1 domain-containing protein 7A) have been proposed to play a causal role in the development of nephrotic syndrome in patients with THSD7A antibody-positive membranous nephropathy. We hypothesized that removal of these antibodies from plasma could lead to a rapid reduction in proteinuria.
Julia Weinmann-Menke +2 more
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THSD7A-associated membranous nephropathy in a patient with neurofibromatosis type 1
European Journal of Medical Genetics, 2018Target antigens in idiopathic membranous nephropathy (MN) include the phospholipase A2 receptor (PLA2R), and in some cases, the thrombospondin type 1 domain-containing 7A (THSD7A). A notable phenomenon is the high rate of cancer (reported to be as high as 20%) in patients with THSD7A-associated MN.
Juan Chang, Xuanli Tang, Wenbin Guan
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Down-Regulation of miRNA-1303 Promotes the Angiogenesis of HUVECs via Targeting THSD7A
Molecular Biotechnology, 2023Angiogenesis promotes neurological recovery after acute ischemic stroke (AIS), and microRNAs play crucial roles in cerebral angiogenesis. This study found that Homo sapiens-microRNA-1303(miR-1303) was reduced in blood specimens of AIS patients and human umbilical vein endothelial cells after suffering from oxygen-glucose deprivation/reperfusion.
Yanan Zhao +2 more
exaly +3 more sources
THSD7A Positivity Predicts Poor Survival and Is Linked to High FAK Expression and FGFR1-Wildtype in Female Patients with Squamous Cell Carcinoma of the Lung [PDF]
International Journal of Molecular Sciences, 2023 Lung cancer is the leading cause of cancer-related deaths in the western world, with squamous cell carcinoma being one of the most common histological subtypes.
Frank Langer
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Journal of Autoimmunity, 2020 Patients with membranous nephropathy have autoantibodies against PLA2R (up to 80%), or THSD7A (up to 2%). We previously described the immunodominant epitope within PLA2R but epitopes in THSD7A are still unknown.
Rachel Lennon
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THSD7A as a Promising Biomarker for Membranous Nephrosis
Molecular Biotechnology, 2023Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus and one of the leading causes of nephrotic syndrome. The disease exhibits heterogeneous outcomes with approximately 30% of cases progressing to end-stage renal disease. Traditionally, the standard approach of diagnosing MN involves performing a kidney biopsy.
Shuiqing Jiang +5 more
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Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway [PDF]
Journal of Biomedical Science, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Lawrence Yu-Min Liu +2 more
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Refractory THSD7A membranous nephropathy with severe asthma related to eosinophilia
Clinical Nephrology, 2019We report a case of a 50-year-old Japanese man with a history of pediatric asthma diagnosed with nephrotic syndrome after 4 years of relapsing asthma with severe eosinophilia. Thrombospondin type-1 domain-containing 7A membranous nephropathy (THSD7A-MN) was diagnosed based on histological evaluation.
Tomo, Suzuki +8 more
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