Results 111 to 120 of about 58,824 (241)

Tapinarof as a Therapeutic Aryl Hydrocarbon Receptor‐Modulating Agent in the Treatment of Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji, Yoko Fuyuno, Koji Kawamura, Ayako Yumine, Masaki Takemura, Yasutaka Mitamura, Kazuhiko Yamamura, Takeshi Nakahara   +7 more
wiley   +1 more source

Ultrastructural analysis of changes in neurons of the mouse internal anal sphincter during ageing [PDF]

, 2013
Gastrointestinal disorders, including chronic constipation, faecal impaction and incontinence, are a major cause of morbidity in the ...
Colyer, Frances, Davies, Heather, Gamage, Prasanna, Ranson, Richard N., Saffrey, M.Jill, Yeoman, Mark   +5 more
core  

Hyperglycaemia alters thymic epithelial cell function

Journal of Medical Hypotheses and Ideas, 2013
AbstractInsulin-dependent diabetes mellitus (IDDM) is considered to be a consequence of unchecked auto-immune processes. Alterations in immune system responses are thought to be the cause of the disease, but the possibility that altered metabolite levels (glucose) can establish the disease by specifically acting on and altering thymus stroma functions ...
Abramova, Vera Alexandrovna, Belyaev, Nikolai Nikolaevich   +1 more
openaire   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Age-related increase of IGFBP5 promotes mitophagy and apoptosis in thymic epithelial cells

陆军军医大学学报
Objective To investigate the role and underlying mechanism of insulin like growth factor binding protein 5 (IGFBP5), a gene up-regulated with age in thymic epithelial cells, in the pathogenesis of thymic involution.
CHEN Xichan, ZENG Jitao, QU Siming
doaj   +1 more source

Thymic Carcinoma Presenting as Disseminated Intravascular Coagulation

Case Reports in Oncological Medicine, 2014
Thymomas and thymic carcinomas are rare tumors, which originate from the epithelial cells of the thymus. We present a case of thymic carcinoma, which presented with DIC as an initial manifestation.
Mamatha Siricilla, Jawairia Memon, Robert Avery   +2 more
doaj   +1 more source

Intrathymic laminin-mediated interactions: role in T cell migration and development

Frontiers in Immunology, 2015
Intrathymic T cell differentiation is a key process for the development and maintenance of cell-mediated immunity, and occurs concomitantly to highly regulated migratory events. We have proposed a multivectorial model for describing intrathymic thymocyte
Wilson eSavino, DANIELLA AREAS MENDES-DA-CRUZ, Daiane Cristina Ferreira Golbert, Ingo eRiederer, Vinicius eCotta-de-Almeida   +4 more
doaj   +1 more source

Histophysiology of thymic epithelial reticular cells.

Archivum histologicum japonicum, 1982
Thymic epithelial reticular cells together with lymphocytes constitute the thymic parenchyma. Morphologically they are characterized by the stellate aspect forming a cytoreticulum, a large and vesicular nucleus, a tonofilament-rich cytoplasm, and abundance of desmosomes.
W, Savino, G L, Santa-Rosa
openaire   +3 more sources

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Exposing the human nude phenotype [4] [PDF]

, 1999
Peer reviewedSubmitted ...
Ahmad, W., Aita, V. M., Baden, H., Brissette, J. L., Christiano, A. M., Cserhalmi-Friedman, P. B., Frank, J., Gaetaniello, L., Gordon, D., Ott, J., Panteleyev, A. A., Pignata, C., Pozzi, N., Prowse, David M., Uyttendaele, H., Weiner, L.   +15 more
core   +1 more source