Results 131 to 140 of about 4,567,849 (254)

Primary explants of the postnatal thymus allow the expansion of clonogenic thymic epithelial cells that constitute thymospheres. [PDF]

Stem Cell Res Ther, 2023
Ocampo-Godinez JM, Gonzalez-Quiroz JL, Cote-Palafox H, George E, Vergara-Lope Nuñez JA, Villagomez-Olea G, Vazquez-Vazquez FC, Lopez-Villegas EO, Leon-Avila G, Dominguez-Lopez ML, Alvarez-Perez MA.   +10 more
europepmc   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Thymic epithelial cells. I. Expression of strong suppressive (veto) activity in mouse thymic epithelial cell cultures

, 1990
We show that thymic epithelial cells grown under serum-free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T-cell ...
Ropke, C, Claesson, Mogens Helweg
core   +1 more source

Myasthenia Gravis and Thymoma

Muscle &Nerve, Volume 74, Issue 4, Page 1156-1173, October 2026.
ABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Benjamin Claytor, Lukas Delasos, Daniel P. Raymond, Erik Seroogy, Jason Lempel, Yuebing Li   +5 more
wiley   +1 more source

Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells. [PDF]

Front Immunol, 2023
Xiao S, Zhang W, Li J, Manley NR.
europepmc   +1 more source

Immune dysregulation in the prostates of C57BL/6Aire−/− mice mirrors that seen in human benign prostatic hyperplasia

The Journal of Pathology, Volume 270, Issue 2, Page 211-225, October 2026.
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman, Jiang Yang, Simon W Hayward, Timothy L Ratliff   +12 more
wiley   +1 more source

A single-cell atlas revealing cellular heterogeneity across healthy and diseased human thymus

Nature Communications
The human thymus plays a key role in the development of the adaptive immune system. Its development and pathologic aberrations with missing involution occupy the scientific world for years.
Martin Direder, Matthias Wielscher, Melanie Salek, Maria Laggner, Dragan Copic, Katharina Klas, Daniel Bormann, Bahar Golabi, Hannes Kühtreiber, Marie-Therese Lingitz, Leonhard Müllauer, Ana-Iris Schiefer, Wolfgang Weninger, Clemens Aigner, Hendrik Jan Ankersmit, Michael Mildner, Bernhard Moser   +16 more
doaj   +1 more source

Thymic Involution and Function in People With HIV and General Population Controls: A Cross‐Sectional Analysis From Two Danish Cohort Studies

Aging Cell, Volume 25, Issue 10, October 2026.
Thymic involution, the age‐related replacement of thymic soft tissue by fat, has been linked to immunosenescence and chronic inflammation. Whether HIV infection affects thymic involution remains unclear. We found that people with HIV on long‐term antiretroviral therapy had more thymic tissue than controls, indicating less thymic involution. More thymic
Manon C. Vanbellinghen, Anders Boyd, Andreas Ohrt Johansen, Moises Alberto Suarez‐Zdunek, Andreas Dehlbæk Knudsen, Thomas Skårup Kristensen, Jørgen Tobias Kühl, Per Ejlstrup Sigvardsen, Michael Huy Cuong Pham, Andreas Fuchs Larsen, Klaus Fuglsang Kofoed, Børge Grønne Nordestgaard, Shoaib Afzal, Neeltje Kootstra, Susanne Dam Nielsen, Peter Reiss   +15 more
wiley   +1 more source

Interferons Mediate Terminal Differentiation of Human Cortical Thymic Epithelial Cells

, 2002
In the thymus, epithelial cells comprise a heterogeneous population required for the generation of functional T lymphocytes, suggesting that thymic epithelium disruption by viruses may compromise T-cell lymphopoiesis in this organ.
Olga Azocar, Christine Servet-Delprat, Yona Zaffran, Hélène Valentin, Pierre-Olivier Vidalain, T. Fabian Wild, David Laine, Chantal Rabourdin-Combe   +7 more
core   +1 more source

Thymus research in relation to myasthenia gravis: a new perspective on cell subpopulations and future directions

Frontiers in Immunology
The thymus generates T cells from immature thymocytes and prevents autoimmune diseases through negative selection and the generation of FOXP3+ regulatory T cells (Tregs).
Naoko Matsui, Izumi Ohigashi, Izumi Ohigashi, Alexander Marx   +3 more
doaj   +1 more source