Results 151 to 160 of about 58,824 (241)

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

Thymus research in relation to myasthenia gravis: a new perspective on cell subpopulations and future directions

Frontiers in Immunology
The thymus generates T cells from immature thymocytes and prevents autoimmune diseases through negative selection and the generation of FOXP3+ regulatory T cells (Tregs).
Naoko Matsui, Izumi Ohigashi, Izumi Ohigashi, Alexander Marx   +3 more
doaj   +1 more source

Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells. [PDF]

Front Immunol, 2023
Xiao S, Zhang W, Li J, Manley NR.
europepmc   +1 more source

The Association Between Allergic Rhinitis, Eosinophilic Inflammation, and Postoperative Recurrence in Nasal Polyps

Otolaryngology–Head and Neck Surgery, Volume 174, Issue 5, Page 1188-1196, May 2026.
Abstract Objective Although allergic rhinitis (AR) commonly co‐occurs with chronic rhinosinusitis with nasal polyps (CRSwNP), its impact on tissue endotypes and prognosis remains unclear. This study examines the impact of AR on CRSwNP, focusing on its links to tissue eosinophilic inflammation and postoperative recurrence risk.
Wei Zhong, Shaobing Xie, Haijun He, Hua Zhang, Weihong Jiang, Can Liao, Zhihai Xie   +6 more
wiley   +1 more source

AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma. [PDF]

Cancer Med, 2023
Matsumoto M, Ohmura T, Hanibuchi Y, Ichimura-Shimizu M, Saijo Y, Ogawa H, Miyazawa R, Morimoto J, Tsuneyama K, Matsumoto M, Oya T.   +10 more
europepmc   +1 more source

Cystic cervical thymoma in a cat

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 12‐year‐old, female, neutered Persian cat was presented with a 4‐month history of a progressively enlarging, soft, fluctuating, ventral cervical mass that intermittently caused dysphagia and coughing. Repeated aspiration temporarily reduced the swelling.
Rachel L. Nixon, Andreu Masdefiol Garriga, Sophie Griffin, Dario Costanza, Kathryn M. Pratschke   +4 more
wiley   +1 more source

Perp Deficiency Induces Defective Negative Selection and Autoimmune Arthritis in Aged Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Perp deficiency promotes age‐related autoimmunity. ABSTRACT Thymic negative selection is characterized by the apoptosis of autoreactive thymocytes and plays a critical role in maintaining self‐tolerance. Numerous apoptosis‐related genes influence cell fate during T‐cell development.
Yan Zhou, Junrong Li, Xiao Leng, Jiao Shi, Gan Zhang, Shan Chen, Dong Liu, Qian Deng, Yan He, Guixiu Shi, Ying Xu, Yuan Liu, Yantang Wang   +12 more
wiley   +1 more source

Identification of a Candidate CD5 Homologue in the Amphibian Xenopus laevis [PDF]

, 1995
We identified a novel T cell Ag in the South African clawed toad (Xenopus laevis) by a mAb designated 2B1. This Ag is present in relatively high levels on most thymocytes, approximately 65% of splenocytes, 55% of PBL, and 65% of intestinal lymphocytes ...
Cooper, Max D., Gartland, Lanier A., Göbel, Thomas W. F., Horton, John D., Jürgens, Jutta B., Pasquier, Louis D.   +5 more
core  

Acute irradiation causes a long-term disturbance in the heterogeneity and gene expression profile of medullary thymic epithelial cells. [PDF]

Front Immunol, 2023
Horie K, Namiki K, Kinoshita K, Miyauchi M, Ishikawa T, Hayama M, Maruyama Y, Hagiwara N, Miyao T, Murata S, Kobayashi TJ, Akiyama N, Akiyama T.   +12 more
europepmc   +1 more source