T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
Aging Cell, Volume 25, Issue 5, May 2026.Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu +3 more
wiley +1 more source
Somatic Mutations of Thymic Epithelial Tumors Identified in the Prospective THYMOGENE Trial
Thoracic CancerBackground The molecular landscape of thymic epithelial tumors has been partially elucidated. GTF2I mutation drives the pathogenesis in approximately 50% of tumors; however, the key molecular aberrations in the other cases remain unclear.
Eleonora Pardini +16 more
doaj +1 more source
Transcriptional and epigenetic regulation in thymic epithelial cells. [PDF]
Immunol Rev, 2022 Martinez-Ruíz GU +2 more
europepmc +1 more source
From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki +2 more
wiley +1 more source
Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells. [PDF]
Cells, 2022 Xu X +11 more
europepmc +1 more source
Thymic B cells in aging and autoimmune disease
Frontiers in ImmunologyThymic B cells comprise a heterogenous population of cells localized primarily within the thymic medulla, a region populated by professional antigen-presenting cells (APCs) including dendritic cells, medullary thymic epithelial cells (mTECs), and ...
Sarah A. Wedemeyer, Ann V. Griffith
doaj +1 more source
Editorial: Thymus function and aging: A focus on thymic epithelial cells. [PDF]
Front Immunol, 2022 Shichkin VP +3 more
europepmc +1 more source
Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice.
PLoS BiologyAge-related thymic involution leads to diminished output of naïve T-cells. While this process is suggested to increase the risk of disease severity in the elderly following infection, direct evidence is lacking.
Abigail Morales-Sánchez +13 more
doaj +1 more source
CCK2-receptor deficiency impairs immune balance by influencing CD4+ T cells development by inhibiting cortical-thymic-epithelial-cells. [PDF]
Exp Biol Med (Maywood), 2023 Zhang D +11 more
europepmc +1 more source
Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1 [PDF]
, 1985 We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day ...
Diamantstein, T. +6 more
core