Results 181 to 190 of about 4,567,849 (254)

BM-MSC-derived migrasomes reverse stroke-induced thymic atrophy and immunosuppression via Pin1 delivery to thymic epithelial cells. [PDF]

J Neuroinflammation
Yi H, Hu M, Yuan L, Su X, Wu S, Li T, Wang S, Kang X, Liu Y, Liu Z, Qin Q, Yu W, Li Y, Qiu W, Cai W, Lu Z.   +15 more
europepmc   +1 more source

The Thymic Microenvironment Shapes Age‐Related Qualitative Changes in the TCR Repertoire

Aging Cell, Volume 25, Issue 9, September 2026.
Ageing profoundly alters the thymic microenvironment, but its impact on T‐cell receptor (TCR) repertoire selection remains unclear. By sequencing TCRαβ repertoires from young and aged thymus, hydrocortisone‐depleted thymus and RAG1‐deficient thymus transplantation models, we show that the aged thymic microenvironment drives qualitative changes in TCR ...
Jasmine Rowell, Diana C. Yanez, Susan Ross, Ching‐In Lau, Eden Zhang, Amir Monfared, Oscar A. Peña, Benny Chain, Tessa Crompton   +8 more
wiley   +1 more source

Thymus Degeneration in Women and the Influence of Female Sexual Hormones on Thymic Epithelial Cells. [PDF]

Int J Mol Sci
Zhou M, Shu Y, Gao J.
europepmc   +1 more source

Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection. [PDF]

J Exp Med, 2022
Postoak JL, Song W, Yang G, Guo X, Xiao S, Saffold CE, Zhang J, Zhang J, Joyce S, Manley NR, Wu L, Van Kaer L.   +11 more
europepmc   +1 more source

Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging

Aging Cell, Volume 25, Issue 9, September 2026.
The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians. Supplementation of AKK extends healthspan and alleviates age‐related decline through direct host–microbe interactions and its bioactive derivatives, which collectively enhance gut barrier integrity, restore metabolic homeostasis ...
Ting Zhang, Jinyuan Niu, Xiaoyu Hu, Zhiang Hu, Yuan Gao, Jialiang Liu, Ning Chen, Yaomin Hu   +7 more
wiley   +1 more source

Correction: Generation and repair of thymic epithelial cells. [PDF]

J Exp Med
Anderson G, Cosway EJ, James KD, Ohigashi I, Takahama Y.   +4 more
europepmc   +1 more source

Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer? [PDF]

Front Immunol, 2022
Qi Y, Zhang R, Lu Y, Zou X, Yang W.
europepmc   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

Allergy, Volume 81, Issue 9, Page 3345-3360, September 2026.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton, Manuel A. R. Ferreira, Wei Keat Lim, Carlo Sidore, Matthew F. Wipperman, Wenzhen Ge, Xue Song, Changming Xia, Julie E. Horowitz, Andrea T. Hooper, Sara C. Hamon, Jennifer Maloney, Jamie M. Orengo, Zhen Chen, Stephanie Amato Ricci, Bolanle Akinlade, Aris Baras, Gary Herman, Brandy L. Bennett, George D. Yancopoulos   +19 more
wiley   +1 more source

Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells

, 2013
Michael M Miazgowicz,1,2 Molly S Elliott,3 Jason S Debley,3 Steven F Ziegler1,21Immunology Program, Benaroya Research Institute, Seattle, WA, 2Department of Immunology, University of Washington School of Medicine, Seattle, WA, 3The Center for Immunology ...
Ziegler SF, Elliott MS, Debley JS, Miazgowicz MM   +3 more
core  

Sample Preparation and Integrative Data Analysis of a Droplet-based Single-Cell ATAC-sequencing Using Murine Thymic Epithelial Cells. [PDF]

Bio Protoc, 2023
Ishikawa T, Ishii H, Miyao T, Horie K, Miyauchi M, Akiyama N, Akiyama T.   +6 more
europepmc   +1 more source