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Correction: Primary explants of the postnatal thymus allow the expansion of clonogenic thymic epithelial cells that constitute thymospheres. [PDF]
Stem Cell Res TherOcampo-Godinez JM +10 more
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RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells. [PDF]
Front Immunol, 2020 Irla M.
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Annual Review of Immunology, 2017
Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity.
Abramson, Jakub, Anderson, Graham
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Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity.
Abramson, Jakub, Anderson, Graham
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Thymic epithelial cell heterogeneity: TEC by TEC
Nature Reviews Immunology, 2019The generation of a functional T cell repertoire in the thymus is mainly orchestrated by thymic epithelial cells (TECs), which provide developing T cells with cues for their navigation, proliferation, differentiation and survival. The TEC compartment has been segregated historically into two major populations of medullary TECs and cortical TECs, which ...
Noam Kadouri +3 more
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Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells
Nature Immunology, 2002The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages.
Jason, Gill +3 more
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Immunological Reviews, 2016
SummaryThe thymus consists of two distinct anatomical regions, the cortex and the medulla; medullary thymic epithelial cells (mTECs) play a crucial role in establishing central T‐cell tolerance for self‐antigens. Although the understanding of mTEC development in thymic organogenesis as well as the regulation of their differentiation and maturation has ...
Yoko, Hamazaki +2 more
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SummaryThe thymus consists of two distinct anatomical regions, the cortex and the medulla; medullary thymic epithelial cells (mTECs) play a crucial role in establishing central T‐cell tolerance for self‐antigens. Although the understanding of mTEC development in thymic organogenesis as well as the regulation of their differentiation and maturation has ...
Yoko, Hamazaki +2 more
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Scandinavian Journal of Immunology, 1990
We show that thymic epithelial cells grown under serum‐free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T‐cell precursors at the clonal level.
Claesson, Mogens Helweg, Ropke, C
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We show that thymic epithelial cells grown under serum‐free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T‐cell precursors at the clonal level.
Claesson, Mogens Helweg, Ropke, C
openaire +2 more sources