Protective and Pathogenic Antibodies to Citrullinated Antigens
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila +5 more
wiley +1 more source
Mapping the Altered Landscape of TCR Repertoire in Autoimmune Diseases
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT Autoimmune diseases arise from the breakdown of immune tolerance through complex interactions between genetic predisposition, environmental exposures, and adaptive immune responses. High‐throughput T‐cell receptor (TCR) repertoire sequencing has transformed our ability to characterize these responses, providing unprecedented insights into ...
Celine Albalaa +3 more
wiley +1 more source
Corrigendum: Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy. [PDF]
Front Endocrinol (Lausanne), 2022 Ahn SH +6 more
europepmc +1 more source
Update on biologic and small molecules treatments in pediatric allergic diseases
Pediatric Allergy and Immunology, Volume 37, Issue 9, September 2026.This graphical abstract summarizes key targets, mechanisms of action, and indications of biologic and small molecules treatments in pediatric allergic diseases.abbreviations : BAS, basophil; BTK, Bruton tyrosine kinase; cDC, conventional dendritic cell; IgE, immunoglobulin E; FCER1, high affinity IgE receptor; IL, interleukin; IL4R, IL4 receptor; JAK ...
Herman T. den Dekker +10 more
wiley +1 more source
Update on Pediatric asthma management: Recent advances
Pediatric Allergy and Immunology, Volume 37, Issue 9, September 2026.Pathophysiology of asthma: an opportunity for personalized targeted therapeutics. Abstract Asthma remains the commonest chronic pediatric respiratory disease and a major cause of childhood morbidity worldwide. Recent advances in pediatric asthma management shift the focus from symptom relief alone towards early control of airway inflammation ...
Nitin Dhochak +2 more
wiley +1 more source
Revisiting CD8+ T Cells in Allergy: The Emerging Role of Tc2 Cells
Scandinavian Journal of Immunology, Volume 104, Issue 3, September 2026.Tc2 CD8+ T cells in Type 2 inflammation: induction, tissue adaptation, metabolic programming, and therapeutic implications. Both naïve CD8+ T cells and pre‐committed Tc1 CD8+ T cells can be directed towards a Tc2 phenotype, characterised by secretion of the Type 2 cytokines IL‐4, IL‐5, IL‐9 and IL‐13, which in turn drive eosinophil recruitment, goblet ...
Sabrina de Souza Ferreira +1 more
wiley +1 more source
Mesenchymal stem cells reverse thymus aging by reprogramming the DNA methylation of thymic epithelial cells. [PDF]
Regen TherYang Z +9 more
europepmc +1 more source
Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6380-6394, 30 August 2026.Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza +6 more
wiley +1 more source
Correction: Primary explants of the postnatal thymus allow the expansion of clonogenic thymic epithelial cells that constitute thymospheres. [PDF]
Stem Cell Res TherOcampo-Godinez JM +10 more
europepmc +1 more source
RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells. [PDF]
Front Immunol, 2020 Irla M.
europepmc +1 more source