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Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells
Nature Immunology, 2002The epithelial component of the thymic microenvironment is indispensable for the generation of T lymphocytes. Although the heterogeneity of this epithelium is well documented, little is known about precursor-progeny relationships between distinct thymic epithelial lineages.
Jason, Gill +3 more
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Thymic epithelial cell culture
Microscopy Research and Technique, 1997Culture of epithelial cells from the thymus of children and laboratory animals has been used for more than two decades to evaluate both the nature of these cells and their importance in the selection and maturation of functional T cells. Especially by the use of serum-free cultures and by establishment of cell lines from cultured thymic epithelial ...
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Development and developmental potential of cortical thymic epithelial cells [PDF]
Immunological Reviews, 2016 The thymic cortex provides a microenvironment for the development and positive selection of immature T cells. Cortical thymic epithelial cells (cTECs), which structurally and functionally support the thymic cortical microenvironment, originate from ...
Yousuke Takahama
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Replication of cytomegalovirus in human thymic epithelial cells
Medical Microbiology and Immunology, 1989Cytomegalovirus (CMV) has often been cited as a cause of immune suppression in children, yet little is known of the mechanisms through which this agent might affect immune function. We have succeeded in using CMV to productively infect cultured human fetal and infantile thymic epithelial (TE) cells. Morphological changes were apparent by 2-4 days after
K, Numazaki +5 more
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Antibodies to thymic epithelial cells in myasthenia gravis
Journal of Neuroimmunology, 1991The presence of anti-thymus antibodies was investigated in the serum of 36 patients with myasthenia gravis (MG). Using an immunofluorescence technique on frozen thymic sections, we found 45% of patients sera reacting with normal or MG thymuses. Staining was confined to subcapsular and medullary keratin-positive epithelial cells.
D, Safar +3 more
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Effects of tacrolimus on rat thymic epithelial cells
Transplantation Proceedings, 2000FK506 is an immunosuppressive agent that was discovered in Japan. Many experiments on organ transplantation have shown the prolongation of allograft survival in animals by treatment with FK506. Previous studies have also shown that FK506 has a remarkable immunosuppressive effect and improves the outcome of liver transplantation.
K, Fujikawa +7 more
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Human Thymic Epithelial Cell Cultures
2003The thymus is a very complex organ that regulates T-cell production Thymocytes (immature T-cells) constitute by far the largest cellular population in the organ (several billions of thymocytes in a child's thymus), but small numbers of other hematopoietic cells are found in the intrathymic microenvironment, such as thymic monocytes, macrophages ...
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Thymic epithelial cell heterogeneity: TEC by TEC
Nature Reviews Immunology, 2019The generation of a functional T cell repertoire in the thymus is mainly orchestrated by thymic epithelial cells (TECs), which provide developing T cells with cues for their navigation, proliferation, differentiation and survival. The TEC compartment has been segregated historically into two major populations of medullary TECs and cortical TECs, which ...
Noam Kadouri +3 more
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Thymic epithelial cells in age‐dependent involution
Microscopy Research and Technique, 2003AbstractAging involves morphological and functional alterations within the microenvironment of the thymus where heterogenous populations of thymic epithelial cells (TEC) play the main roles. The studies performed to date on thymic involution signalize a disturbed interaction between individual thymic compartments that disrupt thymocyte‐TEC interactions
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Clonogenic Culture of Mouse Thymic Epithelial Cells
2019The thymus plays an essential role in the development and selection of T cells by providing a unique microenvironment that is mainly composed of thymic epithelial cells (TECs). We previously identified stem cells of medullary TECs (mTECs) that are crucial for central tolerance induction using a novel clonogenic culture system.
Miho, Sekai +2 more
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