Results 231 to 240 of about 4,567,849 (254)

Thymopoiesis requiresPax9 function in thymic epithelial cells

European Journal of Immunology, 2002
The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches. Here, we show that in Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx.
Hetzer-Egger, Claudia, Schorpp, Michael, Haas-Assenbaum, Annette, Balling, Rudi, Peters, Heiko, Boehm, Thomas   +5 more
openaire   +4 more sources

Notch activation in thymic epithelial cells induces development of thymic microenvironments

Molecular Immunology, 2009
The development and maintenance of thymic microenvironments depends on sustained crosstalk signals derived from developing thymocytes. However, the molecular basis for the initial phase in the lymphoid dependent development of thymic epithelial cells (TECs) remains unclear.
Kyoko, Masuda, Wilfred T V, Germeraad, Rumi, Satoh, Manami, Itoi, Tomokatsu, Ikawa, Nagahiro, Minato, Yoshimoto, Katsura, Willem, van Ewijk, Hiroshi, Kawamoto   +8 more
openaire   +2 more sources

Characterization of human thymic epithelial cell surface antigens: Phenotypic similarity of thymic epithelial cells to epidermal keratinocytes

Journal of Clinical Immunology, 1995
Cellular interactions between developing thymocytes and cells of the thymic microenvironment are necessary for maturation of thymocytes into mature T cells. While much is known about the molecules on developing T cells that mediate these interactions, little is known about the surface molecules of human thymic epithelial (TE) cells.
D D, Patel, L P, Whichard, G, Radcliff, S M, Denning, B F, Haynes   +4 more
openaire   +2 more sources

The adaptive phenotype of cortical thymic epithelial cells

European Journal of Immunology, 2009
AbstractEpithelial cells in the thymus are required for positive and negative selection of developing thymocytes. Although medullary epithelial cells play a major role in negative selection owing to their facility of expressing peripheral self‐antigens, the adaptive features of cortical epithelial cells are largely unknown. A paper in this issue of the
openaire   +3 more sources

Development and Function of Cortical Thymic Epithelial Cells

2013
The thymic cortex provides a microenvironment that supports the generation and T cell antigen receptor (TCR)-mediated selection of CD4(+)CD8(+)TCRαβ(+) thymocytes. Cortical thymic epithelial cells (cTECs) are the essential component that forms the architecture of the thymic cortex and induces the generation as well as the selection of newly generated T
Kensuke, Takada, Izumi, Ohigashi, Michiyuki, Kasai, Hiroshi, Nakase, Yousuke, Takahama   +4 more
openaire   +2 more sources

Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development

Frontiers in Immunology, 2020
Yong Zhao, Hongxia Wang, Yurong Qiu
exaly  

RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells

Frontiers in Immunology, 2021
Magali Irla
exaly  

Thymic Epithelial Cell

2020
openaire   +1 more source

Differentiation of Pluripotent Stem Cells Into Thymic Epithelial Cells and Generation of Thymic Organoids: Applications for Therapeutic Strategies Against APECED

Frontiers in Immunology, 2022
Matthieu Giraud
exaly  

THYMIC EPITHELIAL CELL CONTAINS ACETYLCHOLINE RECEPTOR

The Lancet, 1977
E K, Engel, J L, Trotter, D E, McFarlin, C L, McIntosh   +3 more
openaire   +2 more sources