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Annual Review of Immunology, 2017 Intrathymic T cell development is a complex process that depends upon continuous guidance from thymus stromal cell microenvironments. The thymic epithelium within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenotypic, and functional heterogeneity.
Jakub Abramson, Graham Anderson
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Immunological Reviews, 2016
SummaryThe thymus consists of two distinct anatomical regions, the cortex and the medulla; medullary thymic epithelial cells (mTECs) play a crucial role in establishing central T‐cell tolerance for self‐antigens. Although the understanding of mTEC development in thymic organogenesis as well as the regulation of their differentiation and maturation has ...
Y* Hamazaki, Nagahiro Minato
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SummaryThe thymus consists of two distinct anatomical regions, the cortex and the medulla; medullary thymic epithelial cells (mTECs) play a crucial role in establishing central T‐cell tolerance for self‐antigens. Although the understanding of mTEC development in thymic organogenesis as well as the regulation of their differentiation and maturation has ...
Y* Hamazaki, Nagahiro Minato
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Organogenesis, 2017 This work was supported by the Spanish Ministry of Economy and Competitiveness under grants BFU2013-41112-R and Cell Therapy Network (RD12/0019/0007 and RD16/0011/0002).EphB and their ligands ephrin-B are an important family of protein tyrosine kinase ...
José Javier García-Ceca Hernández +2 more
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Studies on thymic epithelial cells in vitro
Developmental & Comparative Immunology, 1998Thymic epithelial cells are unique in their ability to support positive selection and are essential throughout thymocyte development. Here, we describe a technique for measuring the proliferation of thymic epithelial cells by flow cytometry using a combination of BrdU and pancytokeratin labelling, and we examine the effects of different in vitro ...
K L, Anderson +4 more
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Thymic reticulo-epithelial cells
Expert Opinion on Biological Therapy, 2007The reticulo-epithelial (RE) cellular network of the thymic stromal cellular microenvironment plays a vital role in neuroendocrine regulation and lymphoid cell homing and development. Transmission electronmicroscopic observations have confirmed that there are four functional subtypes of medullar RE cells: undifferentiated; squamous; villous; and cystic.
Bela Bodey
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Scandinavian Journal of Immunology, 1990
We show that thymic epithelial cells grown under serum‐free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T‐cell precursors at the clonal level.
Claesson, Mogens Helweg, Ropke, C
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We show that thymic epithelial cells grown under serum‐free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T‐cell precursors at the clonal level.
Claesson, Mogens Helweg, Ropke, C
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Thymic epithelial cells derived from the cultures of thymic nurse cells
Immunology Letters, 1984Thymic epithelial cells are derived from the cultures of thymic nurse cells. These cultures are free from fibroblasts and macrophages. The epithelial nature of these cells is confirmed by demonstrating the presence of keratin filaments in them. These epithelial cells show heterogeneity in shape, size and distribution of keratin filaments.
D D, Vakharia, N A, Mitchison
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