Results 111 to 120 of about 16,647 (226)

Langerhans cells : sensing the environment in health and disease [PDF]

, 2018
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells.
Deckers, Julie, Hammad, Hamida, Hoste, Esther   +2 more
core   +2 more sources

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, Volume 81, Issue 4, Page 1000-1023, April 2026.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march [PDF]

European Respiratory Review, 2014
It has long been observed that the development of asthma, allergic rhinitis and food allergy are frequently preceded by atopic dermatitis, a phenomenon known as the “atopic march”.
Mei Li
doaj  

Potential Role of Interleukin-25/Interleukin-33/Thymic Stromal Lymphopoietin-Fibrocyte Axis in the Pathogenesis of Allergic Airway Diseases

Chinese Medical Journal, 2018
Objective: Allergic airway diseases (AADs) are a group of heterogeneous disease mediated by T-helper type 2 (Th2) immune response and characterized with airway inflammation and remodeling, including allergic asthma, allergic rhinitis, and chronic ...
Xiu-Juan Yao, Xiao-Fang Liu, Xiang-Dong Wang   +2 more
doaj   +1 more source

TSLP‐targeting therapy: Beyond allergy?

Clinical and Translational Medicine, 2023
Risa Ebina‐Shibuya, Warren J. Leonard
doaj   +1 more source

Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques

, 2015
Delivering vaccine antigens to mucosal surfaces is potentially very attractive, especially as protection from mucosal infections may be mediated by local immune responses.
Buffa, V, Doyle-Meyers, L, Fischetti, L, King, DF, Klein, K, Shattock, RJ, Siddiqui, A, Tregoning, JS, Veazey, RS   +8 more
core   +2 more sources

Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]

, 2019
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke, Edris Mohamed, Ahmed, Joos, Guy, Lahousse, Lies, Maes, Tania   +4 more
core   +1 more source

Thymic Stromal Lymphopoietin (TSLP)

Current allergy and asthma reports
Purpose of the Review: Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithelial-driven chronic inflammatory diseases. This review navigates the existing evidence on TSLP, with a particular focus on asthma, before delving into the current understanding of its role in chronic ...
de Corso, Eugenio, Hellings, Peter W., Fokkens, Wytske J., Klimek, Ludger, Peters, Anju T., Scadding, Glenis K., Desrosiers, Martin, Lee, Stella E., Mullol, Joaquim   +8 more
openaire   +1 more source

Variants in Genes Encoding Innate Lymphoid Cells Type 2 Surface Markers Affecting Asthma and Atopy Pathologies

Clinical &Experimental Allergy, EarlyView.
Raphael Chagas Silva, Gabriela Pimentel Pinheiro, Hátilla dos Santos Silva, Talita dos Santos de Jesus, Carolina Melo Orrico‐Ferreira, Jamille Souza Fernandes Chiarelotto, Cinthia Vila Nova Santana, Carina da Silva Pinheiro, Ricardo Riccio Oliveira, Álvaro Augusto Cruz, Kathleen C. Barnes, Neuza Maria A. Neves, Ryan dos Santos Costa, Camila Alexandrina Figueiredo   +13 more
wiley   +1 more source

Mitochondria‐Related Pathogenic Genes in Paediatric Asthma: A Multi‐Omics Mendelian Randomization Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial‐related genes in paediatric asthma remain unclear. We performed a multi‐omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood‐based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs ...
Biyu Zhang, Yaqin Li, Bo Ding, Xiaoyan Li, Yanming Lu   +4 more
wiley   +1 more source