Results 91 to 100 of about 184,554 (216)

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1309-1317, November 2026.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33

, 2016
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL ...
David Proud (316264), Wei Duan (13099662), David H Broide (19456861), Astrid M Doerner (19456855), Amit K Mehta (19456852), Michael Croft (308875), Bruce L Zuraw (19456864), Suzanne L Traves (19456858)   +7 more
core  

Validation of thymic stromal lymphopoietin as a biomarker of primary Sjögren's syndrome and related lymphoproliferation: results in independent cohorts

, 2020
Thymic stromal lymphopoietin (TSLP) has been implicated in primary Sjögren's syndrome (pSS) and related B-cell lymphoproliferation and lymphoma (NHL) by studies on salivary pathologic tissues and serum.
Giacomelli, Roberto, Gandolfo, Saviana, Goules, Andreas, De Vita, Salvatore, Baldini, Chiara, Ferro, Francesco, Quartuccio, Luca, Kapsogeorgou, Efstathia, Colafrancesco, Serena, Tzioufas, Athanasios G, Alunno, Alessia, Conti, Fabrizio, Fabro, Cinzia, Gerli, Roberto, Priori, Roberta, Valesini, Guido, Bartoloni, Elena   +16 more
core  

Expression of thymic stromal lymphopoietin in canine atopic dermatitis

, 2013
BACKGROUND In humans, thymic stromal lymphopoietin (TSLP) plays a central role in the development of allergic inflammation, such as atopic dermatitis (AD), but it is unknown whether it is involved in the pathogenesis of canine AD (CAD).
Klukowska-Rötzler, Jolanta, Müller, Eliane Jasmine, Chervet, Ludovic, Roosje, Petra, Marti, Eliane Isabelle, Janda, Jozef, Müller EJ, Roosje P, Janda J, Chervet L, Klukowska, Jolanta, Roosje Hasler, Pieternella, Marti E, Klukowska-Rötzler J   +13 more
core   +1 more source

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells [PDF]

, 2001
The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a
Gorman, D M, Waal-Malefyt, Rene de, Man-ru Liu, Marilyn Travis, Rene de Waal Malefyt, Spits, H, Bazan, Fernando, Vassili Soumelis, Sandra M. Zurawski, Reche Gallardo, Pedro Antonio, Liu, MR, Johnston, J, Clifford, T, Kastelein, Robert A., Robert A. Kastelein, Soumelis, Vassili, J. Fernando Bazan, Travis, M, Pedro A. Reche, Hergen Spits, Daniel M. Gorman, Yong-Jun Liu, Zurawski, Sandra M., Teresa Clifford, Liu, Yong-Jun, Jim Johnston   +25 more
core   +3 more sources

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma

Cell Communication and Signaling, 2008
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype.
Kuepper Michael, Borowski Andreas, Sebastian Katrin, Friedrich Karlheinz   +3 more
doaj   +1 more source

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1342-1351, November 2026.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

The role of thymic stromal lymphopoietin (TSLP) in allergic disorders [PDF]

Current Opinion in Immunology, 2010
The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways and gastrointestinal tract.
openaire   +2 more sources

Targeting thymic stromal lymphopoietin in nasal type 2 inflammation

Eye & ENT Research
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li, Jingjing Guo, Jing Song, Ming Wang   +3 more
doaj   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3819-3830, November 2026.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source