Results 81 to 90 of about 10,752 (180)
Revisiting CD8+ T Cells in Allergy: The Emerging Role of Tc2 Cells
Scandinavian Journal of Immunology, Volume 104, Issue 3, September 2026.Tc2 CD8+ T cells in Type 2 inflammation: induction, tissue adaptation, metabolic programming, and therapeutic implications. Both naïve CD8+ T cells and pre‐committed Tc1 CD8+ T cells can be directed towards a Tc2 phenotype, characterised by secretion of the Type 2 cytokines IL‐4, IL‐5, IL‐9 and IL‐13, which in turn drive eosinophil recruitment, goblet ...
Sabrina de Souza Ferreira +1 more
wiley +1 more source
Chinese Medical Journal, 2018 Objective: Allergic airway diseases (AADs) are a group of heterogeneous disease mediated by T-helper type 2 (Th2) immune response and characterized with airway inflammation and remodeling, including allergic asthma, allergic rhinitis, and chronic ...
Xiu-Juan Yao +2 more
doaj +1 more source
Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6380-6394, 30 August 2026.Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza +6 more
wiley +1 more source
The role of thymic stromal lymphopoietin (TSLP) in allergic disorders [PDF]
Current Opinion in Immunology, 2010 The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways and gastrointestinal tract.
openaire +2 more sources
TSLP‐targeting therapy: Beyond allergy?
Clinical and Translational Medicine, 2023 Risa Ebina‐Shibuya, Warren J. Leonard
doaj +1 more source
Thymic Stromal Lymphopoietin (TSLP)
Current allergy and asthma reportsPurpose of the Review: Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithelial-driven chronic inflammatory diseases. This review navigates the existing evidence on TSLP, with a particular focus on asthma, before delving into the current understanding of its role in chronic ...
de Corso, Eugenio +8 more
openaire +1 more source
Potential of alarmin-targeted bispecific and combination therapies in airway disease
Frontiers in AllergyThymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are epithelial-derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).
H. Kiyomi Komori, Hector Ortega
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Clinical, Cosmetic and Investigational Dermatology, 2022 Yu-qing Hu, Jian-zhong Zhang Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic ChinaCorrespondence: Jian-zhong Zhang, Tel +86-10-88325472, Fax +86-10-68318386, Email rmzjz@126.comBackground: Bullous pemphigoid (BP)
Hu YQ, Zhang JZ
doaj
The last step to achieve barrier damage control
Frontiers in ImmunologyHeterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role ...
Ilaria Baglivo +5 more
doaj +1 more source
Guangxi Yike Daxue xuebaoObjective To explore the mechanism of thymic stromal lymphopoietin (TSLP) in regulating lipopolysaccharide (LPS) -induced inflammation in mouse hepatocytes. Methods Ten male C57BL/6J wild-type (WT) mice and 10 male TSLP receptor-deficient (TSLPR-/-) mice
Jiarui ZHANG, Shaolei WU, Shilai LI
doaj +1 more source