Results 61 to 70 of about 184,554 (216)

Topical Tetracycline Improves MC903-induced Atopic Dermatitis in Mice through Inhibition of Inflammatory Cytokines and Thymic Stromal Lymphopoietin Expression

Chinese Medical Journal, 2016
Background: Tetracycline (TET) has been found to have both antibiotic and anti-inflammatory properties. The anti-inflammatory effect of topical TET on atopic dermatitis (AD) has not been reported.
Xiao-Jing Liu, Zhang-Lei Mu, Yan Zhao, Jian-Zhong Zhang   +3 more
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Upregulated thymic stromal lymphopoietin receptor expression in children with asthma

, 2017
Background Thymic stromal lymphopoietin (TSLP) plays an important role in pathogenesis in patients with asthma. However, the role of thymic stromal lymphopoietin receptor (TSLPR) and correlation with IL-7R alpha and clinical severity in asthmatic or ...
江伯倫, Lin, Sheng-Chieh;Huang, Jian-Jhang;Wang, Jiu-Yao;Chuang, Hsiao-Chi;Chiang, Bor-Luen;Ye, Yi-Ling   +1 more
core   +1 more source

Discovery of Natural Dual Inhibitors from ZINC Database Targeting Thymic Stromal Lymphopoietin (TSLP) and Interleukin-33 (IL-33) as Potential Anti-Allergy Agents - MD Simulation XVG Files and Complex PDB Files (Docking Results)

, 2021
<p>This repository contains input and output files of MD simulations along with MM/PBSA related files</p> <p>Manuscript Title: Discovery of Natural Dual Inhibitors from ZINC Database Targeting Thymic Stromal Lymphopoietin (TSLP) and ...
Jayaraman, Muthukumaran, Mohammed Auwal, Ibrahim, Olatomide A., Fadare, Abdullahi, Ibrahim Uba, Adamu, Rahma Muhammad   +4 more
core   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

eLife, 2021
Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation.
Risa Ebina-Shibuya, Erin E West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B McGavern, Warren J Leonard   +10 more
doaj   +1 more source

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source

Molecular cloning and characterization of equine thymic stromal lymphopoietin

, 2010
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that plays a central role in T helper 2 (Th2) cell differentiation and allergic inflammation.
Klukowska-Rötzler, Jolanta, Leeb, Tosso, Marti, Eliane Isabelle, Bugno, M., Janda, Jozef, Klukowska, Jolanta, Bugno M, Leeb T, Marti E, Klukowska-Rötzler J, Janda J, E. Marti, J. Janda, T. Leeb, J. Klukowska-Rötzler, M. Bugno   +15 more
core   +1 more source

Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation. [PDF]

, 2008
Hematopoietic stem cell transplantation (HSCT) requires conditioning treatments such as irradiation, which leads to a severely delayed recovery of T cell immunity and constitutes a major complication of this therapy.
Linda Kenins, Kenins, L., Richard L. Boyd, Holländer, G. A., Wodnar-Filipowicz, A., Jason W. Gill, Boyd, R. L., Gill, J. W., Georg A. Holländer, Aleksandra Wodnar-Filipowicz, Gill JW, Holländer GA, Wodnar-Filipowicz A, Kenins L, Boyd RL   +14 more
core   +1 more source

Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Establishment of a Modified Allergic Dermatitis Model in Mouse Ear Lobes by Application of 12-O-Tetradecanoyl Phorbol 13-Acetate: Putative Involvement of Thymic Stromal Lymphopoietin and Roles of Histamine

Journal of Pharmacological Sciences, 2009
.: We established a novel allergic dermatitis model in mouse ear lobes in which antigen-nonspecific inflammation was induced by painting 12-O-tetradecanoylphorbol 13-acetate (TPA) between sensitization and challenge with picryl chloride (PiCl).
Noriyasu Hirasawa, Yuhsuke Ohsawa, Kenji Ishihara, Toshio Seyama, JangJa Hong, Kazuo Ohuchi   +5 more
doaj   +1 more source