Results 141 to 150 of about 21,196 (261)

TSLP‐targeting therapy: Beyond allergy?

Clinical and Translational Medicine, 2023
Risa Ebina‐Shibuya, Warren J. Leonard
doaj   +1 more source

Targeting thymic stromal lymphopoietin in nasal type 2 inflammation

Eye & ENT Research
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li, Jingjing Guo, Jing Song, Ming Wang   +3 more
doaj   +1 more source

Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]

, 2019
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke, Edris Mohamed, Ahmed, Joos, Guy, Lahousse, Lies, Maes, Tania   +4 more
core   +1 more source

Ursolic acid downregulates thymic stromal lymphopoietin through the blockade of intracellular calcium/caspase‑1/NF‑κB signaling cascade in HMC‑1 cells.

International Journal of Molecular Medicine, 2019
Thymic stromal lymphopoietin (TSLP) plays an important role in allergic disorders, including atopic dermatitis and asthma. Ursolic acid (UA) has various pharmacological properties, such as antioxidant, anti‑inflammatory and anticancer.
P. Moon, Na‐Ra Han, Jin Soo Lee, Hyung‐Min Kim, Hyun‐Ja Jeong   +4 more
semanticscholar   +1 more source

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn‐Han Lee, Imane Chamkhi, Abdelhakim Bouyahya   +8 more
wiley   +1 more source

Thymic Stromal Lymphopoietin (TSLP)

Current allergy and asthma reports
Purpose of the Review: Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithelial-driven chronic inflammatory diseases. This review navigates the existing evidence on TSLP, with a particular focus on asthma, before delving into the current understanding of its role in chronic ...
de Corso, Eugenio, Hellings, Peter W., Fokkens, Wytske J., Klimek, Ludger, Peters, Anju T., Scadding, Glenis K., Desrosiers, Martin, Lee, Stella E., Mullol, Joaquim   +8 more
openaire   +1 more source

Thymic stromal lymphopoietin levels are increased in patients with celiac disease

Biomolecules & Biomedicine, 2019
Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells in the lungs, skin, and intestinal mucosa and is involved in several physiological and pathological processes.
Evrim Kahramanoğlu Aksoy, Muhammet Yener Akpınar, Ferdane Pirinççi Sapmaz, Özlem Doğan, Metin Uzman, Yaşar Nazlıgül   +5 more
doaj   +1 more source

Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation

Allergy Asthma and Immunology Research, 2019
Purpose Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2.
Ha Jung Kim, Seung Hwa Lee, Sekyoo Jeong, S. Hong   +3 more
semanticscholar   +1 more source

Predicting Role of Interleukin‐33 in Determining the Development and Severity of Atopic Dermatitis

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Introduction Atopic dermatitis (AD), also referred to as atopic eczema, is one of the most common immunological disorders in children. Previous studies have suggested potential roles of interleukin‐33 (IL‐33) in the onset and progression of AD.
Ali‐reza Ghasemiyeh, Marzieh Heidarzadeh Arani, Fatemeh Riazian, Ali Aghajani, Mohammad Javad Azadchehr, Hossein Motedayyen   +5 more
wiley   +1 more source

The Effect of Thymic Stromal Lymphopoietin on Reflux Esophagitis

Journal of Physiological Investigation
Reflux esophagitis (RE) is characterized by the infiltration of inflammatory cells into the damaged squamous epithelium. Thymic stromal lymphopoietin (TSLP) has been implicated in promoting T helper type 2 (Th2) inflammation.
Ruidong Chen, Longfei Zhao, Yunyun Hu, Hong Li   +3 more
doaj   +1 more source