Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer [PDF]
Frontiers in Immunology, 2018 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi +14 more
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Thymic Stromal Lymphopoietin–Driven B-Cell Hyperactivation Impairs Intestinal Epithelial Homeostasis Predisposing to Enterocolitis in Hirschsprung Disease [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Hirschsprung-associated enterocolitis, a lethal complication of Hirschsprung’s disease—a prevalent congenital disorder with high morbidity—has a poorly understood pathogenesis.
Shiwei He +15 more
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Thymic Stromal Lymphopoietin: To Cut a Long Story ShortSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified.
Katerina Tsilingiri +2 more
doaj +2 more sources
Role of thymic stromal lymphopoietin in allergy and beyond [PDF]
Nature Reviews Immunology, 2022 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and recruitment.
Risa Ebina-Shibuya, Warren J. Leonard
openaire +3 more sources
Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells [PDF]
The Journal of Immunology, 2011 Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis. TSLP acts on multiple lineages, including dendritic cells (DCs), T cells, NKT cells, eosinophils, and mast ...
Mohit Kashyap +4 more
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Thymic stromal lymphopoietin in leukemia: A double-edged sword? [PDF]
Leukemia Research ReportsThymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou +6 more
doaj +2 more sources
Functions of thymic stromal lymphopoietin in immunity and disease [PDF]
Immunologic Research, 2012 Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses.
Baohua Zhou +3 more
core +3 more sources
The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]
Childhood Kidney Diseases, 2018 Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee +8 more
doaj +5 more sources
Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march [PDF]
European Respiratory Review, 2014 It has long been observed that the development of asthma, allergic rhinitis and food allergy are frequently preceded by atopic dermatitis, a phenomenon known as the “atopic march”.
Mei Li
doaj +3 more sources
The Effect of Thymic Stromal Lymphopoietin on Reflux Esophagitis
Journal of Physiological InvestigationReflux esophagitis (RE) is characterized by the infiltration of inflammatory cells into the damaged squamous epithelium. Thymic stromal lymphopoietin (TSLP) has been implicated in promoting T helper type 2 (Th2) inflammation.
Ruidong Chen +3 more
doaj +3 more sources