Results 11 to 20 of about 10,319 (186)
Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer [PDF]
Frontiers in Immunology, 2018 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi +14 more
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The Effect of Thymic Stromal Lymphopoietin on Reflux Esophagitis
Journal of Physiological InvestigationReflux esophagitis (RE) is characterized by the infiltration of inflammatory cells into the damaged squamous epithelium. Thymic stromal lymphopoietin (TSLP) has been implicated in promoting T helper type 2 (Th2) inflammation.
Ruidong Chen +3 more
doaj +3 more sources
Role of thymic stromal lymphopoietin in allergy and beyond. [PDF]
Nat Rev Immunol, 2023 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and innate lymphoid cells, affecting their maturation, survival and recruitment.
Ebina-Shibuya R, Leonard WJ.
europepmc +3 more sources
Thymic stromal lymphopoietin [PDF]
Annals of the New York Academy of Sciences, 2010 Thymic stromal lymphopoietin (TSLP) is an epithelial cell‐derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via a TSLP receptor (TSLPR), a heterodimer of the IL‐7 receptor α chain and the TSLPR chain. The TSLPR chain is closely related to the common receptor γ chain that is expressed on a wide range of cell types in the adaptive ...
Rui, He, Raif S, Geha
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Thymic Stromal Lymphopoietin and Cancer [PDF]
The Journal of Immunology, 2014 Abstract Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhematopoietic cell lineages. These include dendritic cells, basophils, mast cells, B cells, epithelial cells, and CD4+, CD8+, and NK T cells. Although TSLP’s
Emma, Lo Kuan, Steven F, Ziegler
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Thymic stromal lymphopoietin controls hair growth [PDF]
Stem Cell Reports, 2022 Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair growth. We demonstrate that thymic stromal lymphopoietin (TSLP) is produced in response to skin injury and during
Shannon, Jessica L. +5 more
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Down-regulation of thymic stromal lymphopoietin by curcumin [PDF]
Pharmacological Reports, 2013 Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the pathogenesis of allergic diseases such as asthma, atopic dermatitis and allergic rhinitis. Curcumin has various effects such as antidepressant, antioxidant, antihyperglycemic, antitumor and anti-inflammatory.
Phil-Dong, Moon +2 more
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The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]
, 2013 Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler +5 more
openaire +2 more sources
Thymic stromal lymphopoietin: a new cytokine in asthma [PDF]
Current Opinion in Pharmacology, 2008 Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans.
Yrina, Rochman, Warren J, Leonard
openaire +2 more sources
Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells
Medicina, 2020 Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as
Phil-Dong Moon +6 more
doaj +1 more source