Results 31 to 40 of about 184,554 (216)

A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis

Haematologica, 2016
Thymic stromal lymphopoietin (TSLP) stimulates in vitro proliferation of human fetal B-cell precursors. However, its in vivo role during normal human B lymphopoiesis is unknown.
Olivia L. Francis, Terry-Ann M. Milford, Shannalee R. Martinez, Ineavely Baez, Jacqueline S. Coats, Karina Mayagoitia, Katherine R. Concepcion, Elizabeth Ginelli, Cornelia Beldiman, Abigail Benitez, Abby J. Weldon, Keshav Arogyaswamy, Parveen Shiraz, Ross Fisher, Christopher L. Morris, Xiao-Bing Zhang, Valeri Filippov, Ben Van Handel, Zheng Ge, Chunhua Song, Sinisa Dovat, Ruijun Jeanna Su, Kimberly J. Payne   +22 more
doaj   +1 more source

Thymic stromal lymphopoietin and the pathophysiology of atopic disease [PDF]

Expert Review of Clinical Immunology, 2009
Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiation and progression of allergic ...
Michael M, Miazgowicz, Mark B, Headley, Ryan P, Larson, Steven F, Ziegler   +3 more
openaire   +2 more sources

Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

Acta Dermato-Venereologica, 2019
Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong, Xia Wu, Wei Zhang, Jie Zhang, Xiaofan Chen, Shihong Chen, Haiyan Huang, Yong Yang, Bo Yu, Xia Dou   +9 more
doaj   +1 more source

Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors

Molecules, 2021
Thymic stromal lymphopoietin (TSLP) plays an important role in the pathophysiology of various allergic diseases that are mediated by T helper cell type-2 (Th2) responses, including asthma and atopic dermatitis.
Hyeji Shin, Yoo Kyong Han, Youngjoo Byun, Young Ho Jeon, Ki Yong Lee   +4 more
doaj   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Lei, Y., Jeker, L. T., Georg A. Holländer, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Nagasawa, T., Izumi Ohigashi, Ripen, A. M., Ohigashi, I., Takashi Nagasawa, Malefyt Rde, W., Adiratna Mat Ripen, Nitta, Takeshi, Ripen, Adiratna Mat, Bösl, Michael R., Lei, Yu, de Waal Malefyt, Rene, Jeker, Lukas T., Ishimaru, Naozumi, Hayashi, Yoshio, Takahama, Yousuke, Ohigashi, Izumi, Nagasawa, Takashi, Holländer, Georg A.   +35 more
core   +1 more source

Exacerbation of Allergic Diseases by Chemicals: Role of TSLP

Journal of Pharmacological Sciences, 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
doaj   +1 more source

Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway [PDF]

, 2015
Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce.
Simone C. Zimmerli, Rincon Garriz, José Maria, Christophe P. Frossard, Frossard, Christophe, Philippe A. Eigenmann, José M. Rincon Garriz, Eigenmann, Philippe, Zimmerli, Simone   +7 more
core   +1 more source

Elevated Plasma Thymic Stromal Lymphopoietin After Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2022
BackgroundThymic stromal lymphopoietin (TSLP), a distant paralog of the cytokine IL-7, has been shown to be associated with atherosclerosis. However, the effect of plasma TSLP level after acute myocardial infarction (AMI) remains largely unclear.
Yuhao Zhao, Yeping Zhang, Zongsheng Guo, Zheng Ma, Ye Liu, Chunming Han, Xinchun Yang, Lei Zhao   +7 more
doaj   +1 more source

The role of thymic stromal lymphopoietin in the development of chronic otitis media with effusion

, 2022
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Purpose: To investigate the effect of thymic stromal lymphopoietin on the development of chronic otitis media with effusion Materials and methods ...
Altındağ, Cem, Özcan, Deniz, Kumral, Tolgar Lütfi, Sarı, Hüseyin, Karaketir, Semih, Yıldırım, Güven, Dikker, Okan, Çakın, Mehmet Can   +7 more
core   +1 more source

Relationship between meconium staining and thymic stromal lymphopoietin

, 2014
OBJECTIVE: Epithelium-derived thymic stromal lymphopoietin (TSLP), is a key pro-allergic cytokine that has recently been linked to chronic airway diseases.
Mollamahmutoglu, L., Engin-Ustun, Y., Yenicesu, O., Demirtas, CANAN, Ozkan, M. S., Eyi, E. G. Y., Aktulay, A.   +6 more
core   +2 more sources