Results 21 to 30 of about 10,752 (180)

Thymic stromal lymphopoietin and allergic disease [PDF]

Journal of Allergy and Clinical Immunology, 2012
The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways, and gastrointestinal tract.
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Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin

Respiratory Research, 2022
Background Up-regulation of aerobic glycolysis has been reported as a characterization of asthma and facilitates airway inflammation. We has been previously reported that short isoform thymic stromal lymphopoietin (sTSLP) could reduce inflammation in ...
Changhui Yu, Wufeng Huang, Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Haijing Zhao, Laiyu Liu, Hangming Dong, Fei Zou, Shaoxi Cai   +10 more
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Functions of thymic stromal lymphopoietin in immunity and disease [PDF]

Immunologic Research, 2012
Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naïve CD4(+) T cell and activate ...
Yanlu, Zhang, Baohua, Zhou
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Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

Medicina, 2020
Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as
Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Hyun-Woo Jee, Ji-Hyeon Kim, Hyung-Min Kim, Hyun-Ja Jeong   +6 more
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A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis

Haematologica, 2016
Thymic stromal lymphopoietin (TSLP) stimulates in vitro proliferation of human fetal B-cell precursors. However, its in vivo role during normal human B lymphopoiesis is unknown.
Olivia L. Francis, Terry-Ann M. Milford, Shannalee R. Martinez, Ineavely Baez, Jacqueline S. Coats, Karina Mayagoitia, Katherine R. Concepcion, Elizabeth Ginelli, Cornelia Beldiman, Abigail Benitez, Abby J. Weldon, Keshav Arogyaswamy, Parveen Shiraz, Ross Fisher, Christopher L. Morris, Xiao-Bing Zhang, Valeri Filippov, Ben Van Handel, Zheng Ge, Chunhua Song, Sinisa Dovat, Ruijun Jeanna Su, Kimberly J. Payne   +22 more
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Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

Acta Dermato-Venereologica, 2019
Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong, Xia Wu, Wei Zhang, Jie Zhang, Xiaofan Chen, Shihong Chen, Haiyan Huang, Yong Yang, Bo Yu, Xia Dou   +9 more
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Thymic stromal lymphopoietin and the pathophysiology of atopic disease [PDF]

Expert Review of Clinical Immunology, 2009
Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiation and progression of allergic ...
Michael M, Miazgowicz, Mark B, Headley, Ryan P, Larson, Steven F, Ziegler   +3 more
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Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors

Molecules, 2021
Thymic stromal lymphopoietin (TSLP) plays an important role in the pathophysiology of various allergic diseases that are mediated by T helper cell type-2 (Th2) responses, including asthma and atopic dermatitis.
Hyeji Shin, Yoo Kyong Han, Youngjoo Byun, Young Ho Jeon, Ki Yong Lee   +4 more
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Thymic stromal lymphopoietin: a new cytokine in asthma [PDF]

Current Opinion in Pharmacology, 2008
Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans.
Yrina, Rochman, Warren J, Leonard
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Exacerbation of Allergic Diseases by Chemicals: Role of TSLP

Journal of Pharmacological Sciences, 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
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