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Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy [PDF]
Int J Mol SciThymic stromal lymphopoietin (TSLP), is a protein belonging to a class of epithelial cytokines commonly called alarmins, which also includes IL-25 and IL-33. Functionally, TSLP is a key player in the immune response to environmental insults, initiating a
Braido, Fulvio +13 more
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Thymic stromal lymphopoietin [PDF]
Annals of the New York Academy of Sciences, 2010 Thymic stromal lymphopoietin (TSLP) is an epithelial cell‐derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via a TSLP receptor (TSLPR), a heterodimer of the IL‐7 receptor α chain and the TSLPR chain. The TSLPR chain is closely related to the common receptor γ chain that is expressed on a wide range of cell types in the adaptive ...
Rui, He, Raif S, Geha
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Thymic Stromal Lymphopoietin and Cancer [PDF]
The Journal of Immunology, 2014 Abstract Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhematopoietic cell lineages. These include dendritic cells, basophils, mast cells, B cells, epithelial cells, and CD4+, CD8+, and NK T cells. Although TSLP’s
Emma, Lo Kuan, Steven F, Ziegler
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Thymic stromal lymphopoietin controls hair growth [PDF]
Stem Cell Reports, 2022 Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair growth. We demonstrate that thymic stromal lymphopoietin (TSLP) is produced in response to skin injury and during
Shannon, Jessica L. +5 more
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Down-regulation of thymic stromal lymphopoietin by curcumin [PDF]
Pharmacological Reports, 2013 Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the pathogenesis of allergic diseases such as asthma, atopic dermatitis and allergic rhinitis. Curcumin has various effects such as antidepressant, antioxidant, antihyperglycemic, antitumor and anti-inflammatory.
Phil-Dong, Moon +2 more
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Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]
, 2010 Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
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The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]
, 2013 Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler +5 more
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Thymic stromal lymphopoietin: a new cytokine in asthma [PDF]
Current Opinion in Pharmacology, 2008 Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans.
Yrina, Rochman, Warren J, Leonard
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Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development
, 2022 SIMPLE SUMMARY: The recurrence rate for lung cancer is high after the removal of the primary tumor. Herein, we demonstrate the potential of immunotherapy against lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine ...
Azin, Marjan +15 more
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Thymic stromal lymphopoietin and allergic disease [PDF]
Journal of Allergy and Clinical Immunology, 2012 The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways, and gastrointestinal tract.
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