Results 191 to 200 of about 16,647 (226)

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

Science, 2021
Sweat out the fat with TSLP! Thymic stromal lymphopoietin (TSLP) is a cytokine that can promote immune responses that characterize allergic diseases. Choa et al . found that mice engineered to produce elevated TSLP displayed selective white adipose tissue loss that protected them from obesity, insulin ...
Ruth Choa, Junichiro Tohyama, Shogo Wada, Hu Meng, Jian Hu, Mariko Okumura, Rebecca M. May, Tanner F. Robertson, Ruth-Anne Langan Pai, Arben Nace, Christian Hopkins, Elizabeth A. Jacobsen, Malay Haldar, Garret A. FitzGerald, Edward M. Behrens, Andy J. Minn, Patrick Seale, George Cotsarelis, Brian Kim, John T. Seykora, Mingyao Li, Zoltan Arany, Taku Kambayashi   +22 more
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Preparation of recombinant human thymic stromal lymphopoietin protein

Preparative Biochemistry & Biotechnology, 2017
Human thymic stromal lymphopoietin (hTSLP) protein plays a central role in inflammation. Characterizing properties of hTSLP requires a recombinant overexpression system that produces correctly folded, active hTSLP. In this report, an efficient overexpression system for the production of hTSLP was developed.
Yanlu Zhang, Liehua Wu, Jingai Yu, JianFeng Mei, Yu Yi, JianShu Chen, Guoqing Ying   +6 more
openaire   +2 more sources

Thymic stromal lymphopoietin and atopic diseases

Revue Française d'Allergologie, 2014
Abstract Studies from the last ten years have seen great progress in recognizing the role of cytokine thymic stromal lymphopoietin (TSLP) in pathogenesis of atopic diseases, particularly atopic dermatitis (AD) and asthma. We provide here a review of the findings from four aspects: (1) TSLP: expression triggers and cellular sources; (2) TSLP receptor:
J.M. Leyva-Castillo, M. Li
openaire   +1 more source

Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Acta Oto-Laryngologica, 2009
Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR.To evaluate the possible role of TSLP in the pathogenesis of AR.We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link ...
Zhonglin, Mou, Jiahong, Xia, Yenong, Tan, Xiangdong, Wang, Yuan, Zhang, Bing, Zhou, Huabin, Li, Demin, Han   +7 more
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Therapy Directed Against Thymic Stromal Lymphopoietin

Drug News & Perspectives, 2008
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine and has been shown to be one of the factors released by epithelial cells following allergen contact with an important role instructing dendritic cells (DCs) to induce a T-helper type 2 (Th2) response.
openaire   +2 more sources

Thymic stromal lymphopoietin is regulated by the intracellular calcium

Cytokine, 2012
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development and progression of allergic diseases such as atopic dermatitis. However, it has not been clarified that TSLP would be regulated by intracellular calcium in mast cells yet.
Na-Ra, Han, Hyung-Min, Kim, Hyun-Ja, Jeong   +2 more
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Functions of thymic stromal lymphopoietin in non-allergic diseases

Cellular Immunology, 2015
Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine produced mainly by epithelial cells. Many studies indicate that TSLP contributes to promote T helper (Th) 2 immune responses which are associated with the pathogenesis of allergic inflammatory diseases.
Guoqing, Ying, Yanlu, Zhang, Guoqiang, Tang, Shuqing, Chen   +3 more
openaire   +2 more sources

Molecular cloning and characterization of equine thymic stromal lymphopoietin

Veterinary Immunology and Immunopathology, 2010
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that plays a central role in T helper 2 (Th2) cell differentiation and allergic inflammation. It is predominantly expressed by epithelial cells, and its expression is increased in patients with atopic dermatitis and asthma.
Klukowska-Rötzler J, Marti E, Bugno M, Leeb T, Janda J   +4 more
openaire   +2 more sources

Thymic stromal lymphopoietin exerts antimicrobial activities.

Experimental dermatology, 2012
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine expressed by epithelial cells and reported to be involved in allergic diseases and atopic eczema. The presence of several predicted α-helical regions in TSPL, a structure characterizing many classical antimicrobial peptides (AMPs), prompted us to investigate whether TSLP exerts ...
Andreas, Sonesson, Gopinath, Kasetty, Anders I, Olin, Martin, Malmsten, Matthias, Mörgelin, Ole E, Sørensen, Artur, Schmidtchen   +6 more
openaire   +1 more source