Results 111 to 120 of about 12,839 (218)

Monoclonal antibodies in type 2 asthma : a systematic review and network meta-analysis [PDF]

, 2019
Since novel treatments to target eosinophilic inflammation in Type 2 asthma are emerging, we aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.
De Feyter, Silke, Edris Mohamed, Ahmed, Joos, Guy, Lahousse, Lies, Maes, Tania   +4 more
core   +1 more source

Variants in Genes Encoding Innate Lymphoid Cells Type 2 Surface Markers Affecting Asthma and Atopy Pathologies

Clinical &Experimental Allergy, EarlyView.
Raphael Chagas Silva, Gabriela Pimentel Pinheiro, Hátilla dos Santos Silva, Talita dos Santos de Jesus, Carolina Melo Orrico‐Ferreira, Jamille Souza Fernandes Chiarelotto, Cinthia Vila Nova Santana, Carina da Silva Pinheiro, Ricardo Riccio Oliveira, Álvaro Augusto Cruz, Kathleen C. Barnes, Neuza Maria A. Neves, Ryan dos Santos Costa, Camila Alexandrina Figueiredo   +13 more
wiley   +1 more source

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Multifactorial Causes and Consequences of TLSP Production, Function, and Release in the Asthmatic Airway

Biomolecules
Disruption of the airway epithelium triggers a defensive immune response that begins with the production and release of alarmin cytokines. These epithelial-derived alarmin cytokines, including thymic stromal lymphopoietin (TSLP), are produced in response
Danica L. Brister, Hafsa Omer, Christiane E. Whetstone, Maral Ranjbar, Gail M. Gauvreau   +4 more
doaj   +1 more source

Serum thymic stromal lymphopoietin (TSLP) levels in atopic dermatitis patients: a systematic review and meta-analysis. [PDF]

Clin Exp Med, 2023
García-Reyes MM, Zumaya-Pérez LC, Pastelin-Palacios R, Moreno-Eutimio MA.   +3 more
europepmc   +1 more source

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Adil Adatia, Subhabrata Moitra, Paige Lacy   +3 more
wiley   +1 more source

Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy.

International journal of clinical and experimental pathology, 2008
The rising worldwide prevalence of asthma has intensified interest in the natural history of asthma. An improved understanding of the genetic, environmental, and developmental factors contributing to the inception and exacerbation of asthma will be crucial to efforts to devise effective preventive and therapeutic interventions.
Esnault, S. (Stéphane), Rosenthal, L.A. (Louis A), Wang, D-S. (Deng-Shun), Malter, J.S. (James S)   +3 more
openaire   +4 more sources

Successful Treatment of Eosinophilic Chronic Rhinosinusitis and Secretory Otitis Media in Refractory Asthma With Thymic Stromal Lymphopoietin (TSLP) Receptor Monoclonal Antibody. [PDF]

Cureus, 2023
Kawashima K, Matsuno O, Okuno M, Kawabe T, Hanada Y.   +4 more
europepmc   +1 more source

Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques

, 2015
Delivering vaccine antigens to mucosal surfaces is potentially very attractive, especially as protection from mucosal infections may be mediated by local immune responses.
Buffa, V, Doyle-Meyers, L, Fischetti, L, King, DF, Klein, K, Shattock, RJ, Siddiqui, A, Tregoning, JS, Veazey, RS   +8 more
core   +2 more sources

Langerhans cells : sensing the environment in health and disease [PDF]

, 2018
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells.
Deckers, Julie, Hammad, Hamida, Hoste, Esther   +2 more
core   +2 more sources