Results 111 to 120 of about 67,342 (249)
Frontiers in Microbiology, 2019 Alpha-herpesvirus thymidine kinase (TK) genes are virulence-related genes and are nonessential for viral replication; they are often preferred target genes for the construction of gene-deleted attenuated vaccines and genetically engineered vectors for ...
Ying Xie +50 more
doaj +1 more source
The processed pseudogene of mouse thymidine kinase is active after transfection
, 1990 Aside of the gene coding for cytoplasmic thymidine kinase, the genome of mouse cells carries two pseudogenes. Both are inactive in situ. One of the pseudogenes is a processed pseudogene in which a two base pair deletion caused a shift of the reading ...
Beck, Gerhard +5 more
core +1 more source
Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies
Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best +5 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2009 Background Activin A increases production of follicle stimulating hormone (FSH) by inducing transcription of its beta subunit (FSHB). This induction has been studied here in LbetaT2 gonadotropes using transient expression of ovine FSHBLuc (-4741 bp of ...
Miller William L, Han Sang-oh
doaj +1 more source
, 2020 [[abstract]]The unique chimeric organization Of the white spot syndrome virus (WSSV) tk-tmk gene encodes a protein which has significant homology to both cellular-type thymidine kinase (TK) and cellular-type thymidylate kinase (TMK), but the functional ...
曾惠芬, Tzeng, HF
core
The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells
, 1984 D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos.
GIULIANO, Michela +4 more
core +1 more source
Advanced Science, Volume 13, Issue 32, 9 June 2026.The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia +15 more
wiley +1 more source
Mechanisms of Pericyte‐Mediated Cancer Metastasis
Advanced Science, Volume 13, Issue 33, 15 June 2026.Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley +1 more source
Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia
Molecular Imaging, 2007 Reporter gene techniques have been applied toward studying the physiologic phenomena associated with tumor hypoxia, a negative prognostic indicator.
Ivana Cecic +6 more
doaj +1 more source
, 1995 We observed that lipopolysaccharide (LPS, 1 μg/ml) can suppress [3H]thymidine incorporation into acid-insoluble fraction in a mouse macrophage cell line: J774 (over 70% at 6 h) without affecting the uptake of [3H]thymidine or DNA polymerase activity ...
Tanigawa, Yoshinori +13 more
core +1 more source