Results 111 to 120 of about 576,830 (232)
Characterization of the thymidine kinase in herpes virus-transformed cells
, 1976 December 1976School of ScienceHerpes simplex virus Type 2 (HSV-2) also codes for a thymidine kinase which is different from the cytosol or mitochondrial forms of the enzyme.
Staczek, John
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Fluorogenic Sydnones for Bioorthogonal Labeling of DNA
Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller +1 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz +8 more
wiley +1 more source
Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia
Molecular Imaging, 2007 Reporter gene techniques have been applied toward studying the physiologic phenomena associated with tumor hypoxia, a negative prognostic indicator.
Ivana Cecic +6 more
doaj +1 more source
Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase
, 2016 Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1). Whereas TK1 is only responsible for thymidine phosphorylation, dCK is capable of converting dC, dA, and dG into their ...
Saugata Hazra (1322079) +4 more
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To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy
European Journal of Haematology, Volume 117, Issue 4, Page 750-766, October 2026.ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino +16 more
wiley +1 more source
N-2 PHENYLDEOXYGUANOSINE A NOVEL SELECTIVE INHIBITOR OF HERPES SIMPLEX THYMIDINE KINASE
, 1988 A series of N2-substituted guanine derivatives was screened against mammalian thymidine kinase and the thymidine kinase encoded by type I herpes simplex virus to examine their capacity to selectively inhibit the viral enzyme.
NOONAN T +8 more
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The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo +9 more
wiley +1 more source
The Human $\beta $-globin Gene and a Functional Viral Thymidine Kinase Gene in Developing Mice
, 1981 THE HUMAN $\BETA $-GLOBIN GENE AND A FUNCTIONAL VIRAL THYMIDINE KINASE GENE IN DEVELOPING MICE The Human $\beta $-globin Gene and a Functional Viral Thymidine Kinase Gene in Developing Mice (78) (-
Wagner, Erwin F. Timothy A. Stewart Beatrice Mintz
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Molecular imaging using positron emission tomography in gastrointestinal malignancy [PDF]
, 2010 Positron Emission Tomography (PET) with 18F-FDG has emerged as a powerful tool in oncology. Furthermore, recent advent of PET/CT and novel tracers are continually expanding its role.
Pakzad, F.
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