Results 101 to 110 of about 576,830 (232)

A sulfur-containing nucleoside antibiotic from Photorhabdus

mBio
We report the discovery of 4′-thiothymidine (4′sT), a sulfur-containing nucleoside antibiotic produced by the nematode symbiont Photorhabdus asymbiotica.
Sangkeun Son, Negar Shahsavari, Thomas Privalsky, Bryson A. Hawkins, Mi-Hyun Lee, Norman Pitt, Akira Iinishi, Raleb Taher, Nikita Gupta, Chandra Sekar Shankar, Jaini Patel, Kim Lewis   +11 more
doaj   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, EarlyView.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, Volume 16, Issue 10, Page 1911-1924, October 2026.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Transcriptional effects of Organochlorine o,p′-DDT and its Metabolite p,p′-DDE in Transfected MDA-MB 231 and MCF-7 Breast Cancer Cell Lines

Research in Molecular Medicine, 2015
Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine ...
Ehsan zayerzadeh, Mohammad Kazem Koohi, Azadeh Fardipour   +2 more
doaj  

The Half-Life of Thymidine Kinase 1 in Serum Measured by ECL Dot Blot: A Potential Marker for Monitoring the Response to Surgery of Patients with Gastric Cancer

The International Journal of Biological Markers, 2002
Thymidine kinase 1 in serum (STK1) of patients with gastric cancer was determined by two methods: ECL dot blot and radioactivity assay. Both measurements showed significantly different values for preoperative STK1 and healthy STK1 (p=0.012 for ECL dot ...
L. Zou, P.-G. Zhang, S. Zou, Y. Li, Q. He Ph.D.   +4 more
doaj   +1 more source

A comparative study of replicative properties of antitumor recombinant vaccinia viruses on human glioblastoma cell culture U87 and monkey kidney cell culture CV-1

Вавиловский журнал генетики и селекции, 2017
In the world of today, virotherapy is one of the rapidly developing areas in the treatment of cancer, and its advantage is selective destruction of cancer cells with minimizing the destructive effect on normal cells of the body. A promising basis for the
R. A. Maksyutov, I. V. Kolosova, T. V. Tregubchak, I. A. Razumov, S. N. Shchelkunov   +4 more
doaj   +1 more source

The role of cyclic AMP in the lipopolysaccharide-induced suppression of thymidine kinase activity in macrophage [PDF]

, 1995
We observed that lipopolysaccharide (LPS, 1 μg/ml) can suppress [3H]thymidine incorporation into acid-insoluble fraction in a mouse macrophage cell line: J774 (over 70% at 6 h) without affecting the uptake of [3H]thymidine or DNA polymerase activity ...
Tanigawa, Yoshinori, Nakamura, Morihiko, Nagao, Shigeki, Xavier, Ricardo Machado, Ishida, Tetsuya, Yuj Harada, Shigeki Nagao, Morihiko Nakamura, Yoshinori Tanigawa, Ricardo Machado Xavier, Harada, Yuj, Tetsuya Ishida, Fumito Okada, Okada, Fumito   +13 more
core   +1 more source

Feasibility of multi‐energy CT and fat fraction MRI for characterizing active bone marrow response to pelvic external beam radiation therapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Pelvic external beam radiation therapy (EBRT), frequently exposes a substantial fraction of active bone marrow (ABM), leading to radiation‐induced marrow suppression and associated hematologic toxicity. Accurate delineation and quantitative assessment of ABM are therefore essential to enable marrow‐sparing radiotherapy strategies ...
Carolyn Eckrich, Kristin Bradley, Bethany Anderson, Diego Hernando, Jessica Miller, Jainil Shah, Patrick Wohlfahrt, Michael Lawless   +7 more
wiley   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source