Results 121 to 130 of about 67,342 (249)

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Translational Compensation of a Frameshift Mutation Affecting Herpes Simplex Virus Thymidine Kinase Is Sufficient to Permit Reactivation from Latency

, 2019
Herpes simplex virus thymidine kinase is important for reactivation of virus from its latent state and is a target for the antiviral drug acyclovir.
Griffiths, Anthony, Chen, Shun-Hua, Horsburgh, Brian C., Coen, Donald M.   +3 more
core   +1 more source

Real‐World Efficacy of Metronomic Chemotherapy in Advanced Breast Cancer Across Molecular Subtypes

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective Metronomic chemotherapy (mCHT) is widely used in the treatment of breast cancer due to its low toxicity and convenience. However, there remain real‐world studies with satisfactory samples focusing on mCHT in advanced breast cancer. Methods Enrolled patients were assigned into capecitabine‐based (X‐based) group and other mCHT group ...
Hanxing Zhou, Linmin Chen, Qianyi Lu, Huailiang Wu, Kuikui Jiang, Fei Xu, Shusen Wang   +6 more
wiley   +1 more source

Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.

, 1987
The thymidine analog 5'-ethynylthymidine was a potent inhibitor of herpes simplex virus type 1 (strain KOS)-induced thymidine kinase with a Ki value of 0.09 microM.
Nutter, L M, Bobek, M, Dutschman, G E, Cheng, Y C, Grill, S P, Sharma, R A   +5 more
core   +1 more source

IGLV3‐21R110 and ibrutinib treatment: Results from the double‐blind, randomized, placebo‐controlled GCLLSG CLL12 trial in early‐stage CLL

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract IGLV3‐21R110 is a point mutation enabling autonomous B‐cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL). It has been associated with shorter time to first treatment and overall survival, but its effects have not been evaluated in phase 3 clinical trials or in patients treated with Bruton tyrosine kinase inhibitors.
Deyan Y. Yosifov, Sandra Robrecht, Adam Giza, Palash C. Maity, Armin Riecke, Christof Schneider, Billy M. C. Jebaraj, Rashmi P. Dheenadayalan, Hassan Jumaa, Marc Young, Manish Kumar, Lothar Müller, Ursula Vehling‐Kaiser, Michael Eckart, Werner Freier, Björn Schöttker, Tobias Gaska, Marcel Reiser, Anna‐Maria Fink, Kirsten Fischer, Barbara Eichhorst, Michael Hallek, Petra Langerbeins, Eugen Tausch, Stephan Stilgenbauer   +24 more
wiley   +1 more source

Structure and function of thymidine kinase 1 like enzymes.

, 2007
Structure and function of thymidine kinase 1 like ...
Dario. Segura-Pena (7965260)
core  

Serum thymidine kinase activity in clinically healthy and diseased cats:a potential biomarker for lymphoma

, 2013
The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful
Taylor, Samantha S, Graham, Peter A, von Euler, Henrik P, Westberg, Sara, Dodkin, Steve, Papasouliotis, Kostas, Belshaw, Zoe, Evans, Helen   +7 more
core   +1 more source

The Clinical Significance of Thymidine Kinase 1 Measurement in Serum of Breast Cancer Patients Using Anti-TK1 Antibody

The International Journal of Biological Markers, 2000
The activity of total thymidine kinase in serum (S-TK) has been used as a tumor maker for decades. To date such activity has been determined using [125] I-iodo-deoxyuridine as a substrate.
Q. He, L. Zou, P.A. Zhang, J.X. Lui, S. Skog, T. Fornander   +5 more
doaj   +1 more source

Characterization of the thymidine kinase in herpes virus-transformed cells

, 1976
December 1976School of ScienceHerpes simplex virus Type 2 (HSV-2) also codes for a thymidine kinase which is different from the cytosol or mitochondrial forms of the enzyme.
Staczek, John
core  

THE PROGNOSTIC SIGNIFICANCE OF THYMIDINE KINASE ACTIVITY LEVELS IN METASTATIC COLORECTAL CANCER [PDF]

, 2016
Amaç: Serum timidin kinaz 1 (TK1) tümör hücre proliferasyonunun duyarlı bir belirtecidir. Bu çalışmada palyatif kemoterapi alan metastatik kolorektal kanserli (MKRK) hastalarda serum TK aktivite düzeylerinin prognostik öneminin araştırılması amaçlandı.
Erdoğan Selçuk ŞEBER, Şeber, Erdoğan Selçuk   +1 more
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