Results 121 to 130 of about 576,830 (232)

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

, 2003
International audienceThe affinity of a series of 2', 3'- and 5-modified thymidine analogues for Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) was evaluated.
Munier-Lehmann, H., Herdewijn, Piet, Van Calenbergh, S., Vanheusden, Veerle, van Rompaey, Philippe, Munier-Lehmann, Hélène, van Calenbergh, Serge, Pochet, Sylvie, Vanheusden, V., Van Rompaey, P.   +9 more
core   +1 more source

Chimeric polypeptide of thymidine kinase and thymidylate kinase of shrimp white spot syndrome virus: Thymidine kinase activity of the recombinant protein expressed in a baculovirus/insect cell system 

, 2020
[[abstract]]The unique chimeric organization Of the white spot syndrome virus (WSSV) tk-tmk gene encodes a protein which has significant homology to both cellular-type thymidine kinase (TK) and cellular-type thymidylate kinase (TMK), but the functional ...
曾惠芬, Tzeng, HF
core  

Validation of a novel HPLC-based serum thymidine kinase assay for breast cancer detection [PDF]

BioDiscovery, 2017
Elena Kuzmanova, Marilena Spanou, Emma Leckie, Nikolai Zhelev   +3 more
doaj   +3 more sources

Successful treatment of acyclovir‐resistant herpes simplex virus infection with amenamevir in a patient who received umbilical cord blood transplantation for T‐cell prolymphocytic leukemia

eJHaem
A 34‐year‐old woman received umbilical cord blood transplantation for refractory T‐cell prolymphocytic leukemia after salvage therapy with alemtuzumab.
Yuma Kawamura, Nako Uchibori, Tomoya Arakawa, Tomoki Fujii, Shuto Negishi, Shiori Morikawa, Nobuaki Fukushima, Akio Kohno, Souichi Yamada, Yoshiko Fukui, Shuetsu Fukushi, Kazutaka Ozeki   +11 more
doaj   +1 more source

The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells

, 1984
D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos.
GIULIANO, Michela, TESORIERE, Luisa, VENTO, Renza, CANTORO, G., TESORIERE, G   +4 more
core   +1 more source

Translational Compensation of a Frameshift Mutation Affecting Herpes Simplex Virus Thymidine Kinase Is Sufficient to Permit Reactivation from Latency

, 2019
Herpes simplex virus thymidine kinase is important for reactivation of virus from its latent state and is a target for the antiviral drug acyclovir.
Griffiths, Anthony, Chen, Shun-Hua, Horsburgh, Brian C., Coen, Donald M.   +3 more
core   +1 more source

Senescence in human AC16 cardiac cells is associated with thymidine kinase induction and histone loss. [PDF]

MicroPubl Biol, 2023
Kastury N, Hidalgo V, Pandi B, Li L, Lam MPY, Lau E.   +5 more
europepmc   +1 more source

Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas? [PDF]

Discov Oncol, 2023
Fang Y, Skog S, Ou Q, Chen Z, Liu S, Hei A, Li J, Zhou J, He E, Wan D.   +9 more
europepmc   +1 more source

Thymidine kinase 1 appears to be a marker for the prognosis of hepatocellular carcinoma based on a large-scale, multicenter study. [PDF]

J Cancer Res Clin Oncol, 2023
Jiang Y, Guo L, Han L, Li H, Li C, Wen L, Song Y, Wang Z, Wang P, Guo Q, Zhao W, Liu M, Chen J, Wu Z, Yan Y, Xu K, Gu T, Wu X, He K, Su K, Han Y.   +20 more
europepmc   +1 more source