Results 131 to 140 of about 67,342 (249)

Rational Design of 5‘-Thiourea-Substituted α-Thymidine Analogues as Thymidine Monophosphate Kinase Inhibitors Capable of Inhibiting Mycobacterial Growth

, 2016
Recently, thymidine monophosphate kinase (TMPK) emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. The elucidation of the X-ray structure of TMPK of M.
Jan Balzarini (161754), Hélène Munier-Lehmann (399503), Serge Van Calenbergh (125212), Ineke Van Daele (2306956), Matheus Froeyen (2470210)   +4 more
core   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy

MedComm, Volume 7, Issue 6, June 2026.
Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Zhen Ma, Qing Wang, Yusheng Zhang, Yang Li, Hongwei Wu, Hongjun Yang, Xianyu Li   +6 more
wiley   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Successful treatment of acyclovir‐resistant herpes simplex virus infection with amenamevir in a patient who received umbilical cord blood transplantation for T‐cell prolymphocytic leukemia

eJHaem
A 34‐year‐old woman received umbilical cord blood transplantation for refractory T‐cell prolymphocytic leukemia after salvage therapy with alemtuzumab.
Yuma Kawamura, Nako Uchibori, Tomoya Arakawa, Tomoki Fujii, Shuto Negishi, Shiori Morikawa, Nobuaki Fukushima, Akio Kohno, Souichi Yamada, Yoshiko Fukui, Shuetsu Fukushi, Kazutaka Ozeki   +11 more
doaj   +1 more source

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 254-264, June 2026.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

The Human $\beta $-globin Gene and a Functional Viral Thymidine Kinase Gene in Developing Mice

, 1981
THE HUMAN $\BETA $-GLOBIN GENE AND A FUNCTIONAL VIRAL THYMIDINE KINASE GENE IN DEVELOPING MICE The Human $\beta $-globin Gene and a Functional Viral Thymidine Kinase Gene in Developing Mice (78) (-
Wagner, Erwin F. Timothy A. Stewart Beatrice Mintz
core  

Dynamic Switchable and Transient DNA Condensates Driven by Aptamer‐Ligand or Ion‐Nucleobase Bridged Complexes

Small, Volume 22, Issue 31, 2 June 2026.
Switchable or transient formation and dissociation of the phase‐separated DNA microdroplets generated by metal ions or aptamer‐ligand complexes crosslinking Y‐shaped DNA frameworks and dynamically separated by counter ligands eliminating the bridging metal ions or biocatalysts degrading the aptamer‐ligand complexes, are introduced.
Yichen Han, Yang Sung Sohn, Rachel Nechushtai, Fan Xia, Fujian Huang, Yunlong Qin, Itamar Willner   +6 more
wiley   +1 more source

Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase

, 1991
The thymidine kinases encoded by herpesviruses of higher vertebrates form a distinct group and are unrelated to the thymidine kinases (TKs) of other organisms.
Davison, A.J., Harrison, P.T., Thompson, R.   +2 more
core   +1 more source