Results 141 to 150 of about 67,342 (249)
Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...
Begoña de las Heras +9 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Primary mitochondrial diseases (PMDs) result from genetic variants in nuclear DNA and mitochondrial DNA which commonly lead to aberrant oxidative phosphorylation. The clinical complexity, often attributed to the underlying genetics, includes several distinct syndromes (e.g., Barth syndrome; Pearson syndrome; Mitochondrial encephalomyopathy ...
Sydney Stern +4 more
wiley +1 more source
Senescence in human AC16 cardiac cells is associated with thymidine kinase induction and histone loss. [PDF]
MicroPubl Biol, 2023 Kastury N +5 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5029-5042, June 2026.ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li +9 more
wiley +1 more source
Hiding Human Thymidine Kinase 1 from Apc/C-Mediated Destruction by Thymidine Binding
, 2008 Thymidine kinase 1 (TK1) is a key cytosolic enzyme in the salvage pathway for dTTP synthesis. In mitotic exit, human TK1 (hTK1) is degraded via the anaphase-promoting complex/ cyclosome (APC/C)-Cdh1 pathway to limit dTTP production.
柯博元;張益昌;張智芬 +1 more
core
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Plasminogen activator inhibitor 1 (PAI1) is a secreted protein that also regulates intracellular processes, such as inhibition of endothelial nitric oxide synthase (eNOS). Interaction between Plasminogen Activators (PA) and PAI1 results in a covalent linkage.
Molly McAdow +4 more
wiley +1 more source
Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas? [PDF]
Discov Oncol, 2023 Fang Y +9 more
europepmc +1 more source
Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.
, 2006 Cellular models of mitochondrial thymidine kinase (TK2) deficiency require a reliable method to measure TK2 activity in whole cell extracts containing two interfering deoxyribonucleoside kinases, thymidine kinase 1 (TK1) and deoxycytidine kinase.
PEREZ PEREZ MJ +5 more
core
Molecular imaging using positron emission tomography in gastrointestinal malignancy
, 2010 Positron Emission Tomography (PET) with 18F-FDG has emerged as a powerful tool in oncology. Furthermore, recent advent of PET/CT and novel tracers are continually expanding its role.
Pakzad, F.
core
Thymidine kinase 1 appears to be a marker for the prognosis of hepatocellular carcinoma based on a large-scale, multicenter study. [PDF]
J Cancer Res Clin Oncol, 2023 Jiang Y +20 more
europepmc +1 more source