Results 211 to 220 of about 62,555 (239)
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Cyclic AMP as a regulator of thymidine kinase
Advances in Enzyme Regulation, 1973Abstract Thymidine kinase was partially purified from Yoshida sarcoma cells by DEAE-cellulose column chromatography. The elution pattern showed two distinct peaks (I and II). The former was found both in normal and neoplastic cells and its activity was inhibited by addition of cyclic AMP, whereas the latter was only found in neoplastic cells and its ...
T. Hamazaki +2 more
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Thymidine Kinases: The Enzymes and their Clinical Usefulness
Cancer Biotherapy, 1993Thymidine kinases (TK) convert thymidine, or deoxythymidine (dT) to the respective monophosphate. TK occurs in many different procaryotic and eucaryotic species and different TK isoenzymes are found within the same eucaryotic cell. One isoenzyme (foetal, cytoplasmic, TK1) is associated with cell division while the other (adult, mitochondrial, TK2) is ...
McKelvey-Martin Vj +4 more
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Thymidine kinase, DNA synthesis and cancer
Molecular and Cellular Biochemistry, 1976A resume has been presented of some recent investigations which show that DNA synthesis can be initiated in many types of quiescent animal cells by external stimuli, by introducing a quiescent nucleus into the cytoplasm of a proliferating cell, or by a virus infection. The components of the DNA replication apparatus are described.
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Induction of thymidine kinase by aflatoxin
Life Sciences, 1966Marvin S. Legator, Virginia A. Childs
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Trends in kinase drug discovery: targets, indications and inhibitor design
Nature Reviews Drug Discovery, 2021Helgi B Schiöth +2 more
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Kinase drug discovery 20 years after imatinib: progress and future directions
Nature Reviews Drug Discovery, 2021Darren Cross +2 more
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The feedback inhibition of thymidine kinase
Biochimica et Biophysica Acta, 1963openaire +3 more sources
Kinase inhibition in autoimmunity and inflammation
Nature Reviews Drug Discovery, 2021Ali A Zarrin +2 more
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Lung cancer: New biological insights and recent therapeutic advances
Ca-A Cancer Journal for Clinicians, 2011Suresh S Ramalingam +2 more
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