Results 71 to 80 of about 946,060 (233)
Plants, 2020 Thymidine kinase 1 (TK1) phosphorylates thymidine nucleosides to generate thymidine monophosphate. This reaction belongs to the pyrimidine salvage route that is phylogenetically conserved.
Manuela Nájera-Martínez +7 more
doaj +1 more source
Human Molecular Genetics, 2008 Mitochondrial DNA (mtDNA) depletion syndrome (MDS), an autosomal recessive condition, is characterized by variable organ involvement with decreased mtDNA copy number and activities of respiratory chain enzymes in affected tissues.
H. Akman +9 more
semanticscholar +1 more source
The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25
The FEBS Journal, EarlyView.Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found that the small GTPase Rab25 promoted the expression of ADAMTS5 in ovarian cancer cells through the activation of the NF‐κB signalling pathway.
Shengnan Yuan +7 more
wiley +1 more source
EBioMedicine, 2019 Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway.
Carlos Lopez-Gomez +9 more
doaj
Journal of the European Academy of Dermatology and Venereology, EarlyView.Epidermal sampling of lesional, perilesional and non‐lesional skin from psoriasis and eczema patients as well as healthy skin was used to perform an in depth proteomic analysis. IL‐36γ known to be expressed in lesional psoriasis skin was outperformed by the protease inhibitor Elafin as a disease‐specific epidermal biomarker.
Anna Berekmeri +7 more
wiley +1 more source
2024 European guidelines for the management of genital herpes
Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 4, Page 742-758, April 2025.Genital herpes—guidelines for diagnostic and treatment (2024): strategies for diagnosis, management and follow‐up of the most common sexually transmitted infection. The guidelines covers common clinical scenarios (including recurrent genital herpes), infection during pregnancy and coinfection with human immunodeficiency virus.
Rajul Patel +10 more
wiley +1 more source
Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses
Molecular Therapy: Methods & Clinical Development, 2019 We describe a strategy to achieve footprintless bi-allelic homology-directed repair (HDR) using helper-dependent adenoviruses (HDAds). This approach utilizes two HDAds to deliver the donor DNA.
Donna J. Palmer +2 more
doaj
Single‐cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress
Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.Abstract Responses to external and internal dangers is essential for survival and homeostatic regulation. Hypothalamic corticotropin‐releasing hormone neurons (CRHNs) play a pivotal role in regulating neuroendocrine responses to fear and stress.
Naresh K. Hanchate
wiley +1 more source
Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia
Molecular Imaging, 2007 Reporter gene techniques have been applied toward studying the physiologic phenomena associated with tumor hypoxia, a negative prognostic indicator.
Ivana Cecic +6 more
doaj +1 more source
Harnessing promoter elements to enhance gene editing in plants: perspectives and advances
Plant Biotechnology Journal, Volume 23, Issue 5, Page 1375-1395, May 2025.Summary Genome‐edited plants, endowed with climate‐smart traits, have been promoted as tools for strengthening resilience against climate change. Successful plant gene editing (GE) requires precise regulation of the GE machinery, a process controlled by the promoters, which drives its transcription through interactions with transcription factors (TFs ...
Nikita Gondalia +8 more
wiley +1 more source