Results 71 to 80 of about 67,342 (249)
, 2001 Highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (TK-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (HSV-1 TK), varicella-zoster virus thymidine kinase (VZV-TK ...
KARLSSON A. +9 more
core +1 more source
Advanced Science, EarlyView.Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu +9 more
wiley +1 more source
Urotensin II-induced signaling involved in proliferation of vascular smooth muscle cells
Vascular Health and Risk Management, 2010 Myriam Iglewski, Stephen R GrantDepartment of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas, USAAbstract: The urotensin II receptor, bound by the ligand urotensin II, generates second ­messengers, ie ...
Myriam Iglewski, Stephen R Grant
doaj
Repetitive Imaging of Reporter Gene Expression in the Lung
Molecular Imaging, 2003 Positron emission tomographic imaging is emerging as a powerful technology to monitor reporter transgene expression in the lungs and other organs. However, little information is available about its usefulness for studying gene expression over time ...
Jean-Christophe Richard +5 more
doaj +1 more source
Human thymidine kinase 1. Regulation in normal and malignant cells
, 1995 Biokemi, leukemia, enzyme, kinetics, thymidine kinase ...
B. Munch-Petersen +10 more
core +1 more source
Advanced Science, EarlyView.This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian +10 more
wiley +1 more source
Predicted top 10 scoring drugs of Thymidine kinase.
, 2012 Predicted top 10 scoring drugs of Thymidine kinase.
Xue Xu (138262) +9 more
core +1 more source
Development of a genetic sensor that eliminates p53 deficient cells
Nature Communications, 2017 TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene ...
Jovan Mircetic +4 more
doaj +1 more source
Late-onset thymidine kinase 2 deficiency: a review of 18 cases
Orphanet Journal of Rare Diseases, 2019 Background TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the ‘myopathic form’ of the mitochondrial depletion ...
Cristina Domínguez-González +23 more
doaj +1 more source
Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells [PDF]
, 2007 In non-proliferating cells mitochondrial (mt) thymidine kinase (TK2) salvages thymidine derived from the extracellular milieu for the synthesis of mt dTTP.
RAMPAZZO, CHIARA +5 more
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