Results 91 to 100 of about 102,224 (277)

Promising Cancer Vaccine for Glioblastoma Therapy: A Focus on mRNA Vaccine

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Glioblastoma (GBM) is an aggressive primary brain tumor with poor prognosis and low survival rates. Standard treatments, such as surgery and radiotherapy, are limited by tumor infiltration and resistance. To review current vaccine strategies for GBM, including peptide, virotherapy, cell‐based, and genetic vaccines, with a focus on ...
Sama Barati, Sahar Ghoflchi, Pejman Hosseinzadeh, Sobhan Pouramini, Hossein Hosseini, Mohammad Jalili‐Nik   +5 more
wiley   +1 more source

Survey of Human Mitochondrial Diseases Using New Genomic/Proteomic Tools [PDF]

, 2001
BACKGROUND. We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human ...
Mohr, Scott C., Plasterer, Thomas N., Smith, Temple F.   +2 more
core   +2 more sources

Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster [PDF]

, 2005
The multisubstrate nucleoside kinase of Drosophila melanogaster (Dm-dNK) can be expressed in human solid tumor cells and its unique enzymatic properties makes this enzyme a suicide gene candidate.
Balzarini, J, Bertoli, A, Franco, M, Johansson, M, Karlsson, A   +4 more
core   +1 more source

Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine

Molecules, 2017
One of the main obstacles for cancer therapies is to deliver medicines effectively to target sites. Since stroma cells are developed around tumors, chemotherapeutic agents have to go through stroma cells in order to reach tumors.
Yasuhiro Tsume, Adam J. Drelich, David E. Smith, Gordon L. Amidon   +3 more
doaj   +1 more source

Trifluridine/tipiracil plus bevacizumab as a first‐line treatment for elderly patients with metastatic colorectal cancer (KSCC1602): A multicenter phase II trial

Cancer Medicine, 2021
Background A previous Phase I/II study demonstrated that TAS‐102 (trifluridine/tipiracil [FTD/TPI]) plus bevacizumab (Bev) has encouraging efficacy and controllable safety for patients with previously treated metastatic colorectal cancer.
Eiji Oki, Akitaka Makiyama, Yuji Miyamoto, Masahito Kotaka, Hirofumi Kawanaka, Keisuke Miwa, Akira Kabashima, Tomohiro Noguchi, Kotaro Yuge, Tomomi Kashiwada, Koji Ando, Mototsugu Shimokawa, Hiroshi Saeki, Yoshito Akagi, Hideo Baba, Yoshihiko Maehara, Masaki Mori   +16 more
doaj   +1 more source

Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples [PDF]

, 2013
Emerging evidence has shown that the tumor microenvironment plays a crucial role in prostate cancer (PCa) development and progression. However, the mechanism(s) through which stromal cells regulate epithelial cells and the differences among prostatic ...
Clemente, Luigi Di, Festuccia, Claudio, Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Pasquale, Boris Di, Ranieri, Guido, Ricevuto, Enrico   +7 more
core   +1 more source

Thymidine phosphorylase promotes metastasis and serves as a marker of poor prognosis in hepatocellular carcinoma.

Laboratory investigation; a journal of technical methods and pathology, 2017
Hepatocellular carcinoma (HCC) ranks as one of the most common and lethal malignancies worldwide. A better understanding of the mechanism responsible for HCC metastasis will be helpful for the treatment of HCC patients.
Qiang Zhang, Yang Zhang, Xuejiao Hu, Yuan Qin, Wei-long Zhong, Jing Meng, Ting Xiao, Chun-hong Zhang, Meng Li, Shuang Chen, Hui-juan Liu, Yanrong Liu, Tao Sun, Cheng Yang   +13 more
semanticscholar   +1 more source

Comparison of 5‐Fluorouracil/Leucovorin and Capecitabine as Adjuvant Therapies in Biliary Tract Cancer

Journal of Gastroenterology and Hepatology, Volume 40, Issue 9, Page 2324-2334, September 2025.
ABSTRACT Background The prognosis of biliary tract cancer (BTC) is poor, and recurrence rates remain high even after curative resection. This study aimed to compare the efficacy and safety of capecitabine and 5‐fluorouracil/leucovorin (FL) as adjuvant treatments following curative resection in patients with BTC.
Tae Seung Lee, Young Hoon Choi, Jun Yeol Kim, Myeong Hwan Lee, Kyu‐Hyun Paik, In Rae Cho, Woo Il Kwon, Sang Hyub Lee, In Seok Lee, Myung Ah. Lee, Jin‐Young Jang, Ji Kon Ryu, Yong‐Tae Kim, Woo Hyun Paik   +13 more
wiley   +1 more source

ITA-MNGIE: an Italian regional and national survey for mitochondrial neuro-gastro-intestinal encephalomyopathy [PDF]

, 2016
Mitochondrial neuro-gastro-intestinal encephalomyopathy (MNGIE) is a rare and unavoidably fatal disease due to mutations in thymidine phosphorylase (TP).
Boschetti, E, Caporali, L, Capristo, M, Carelli, V, Casali, C, Cenacchi, G, D'Alessandro, R, D'Angelo, R, DE GIORGIO, Roberto, Gramegna, Ll, Lodi, R, Pinna, Ad, Pironi, L, Rinaldi, R, Stanzani, M, Tonon, C   +15 more
core   +1 more source

Thymidine esters as substrate analogue inhibitors of angiogenic enzyme thymidine phosphorylase in vitro

Bioorganic chemistry (Print), 2016
Sumaira Javaid, Marium Ishtiaq, Muniza Shaikh, Abdul Hameed, M. Iqbal Choudhary   +4 more
openalex   +2 more sources