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Pharmacogenetic Profiling of Genes Associated with Outcomes of Chemotherapy in Omani Healthy Controls. [PDF]

Genes (Basel)
Al-Mahrouqi N, Al Shuaili N, Al-Zadjali S, Pullanhi A, Al-Barwani H, Al-Kindy A, Al-Sharqi H, Al-Baimani K, Al-Moundhri M, Salman B.   +9 more
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Multifunctional role of thymidine phosphorylase in cancer

Trends in Cancer, 2022
Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, maintaining nucleoside homeostasis for DNA repair and replication. In many cancers TP is expressed at high levels and promotes thymidine catabolism, ultimately generating 2-deoxyribose (2dDR) that can support multiple procancer processes, including glycation of proteins,
Becka M. Warfield, Philip Reigan
openaire   +2 more sources

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

International Journal of Surgical Pathology, 2002
The expression of thymidine phosphorylase (TP), a potent chemotactic factor for enothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of imunohistochemical techniques. Results on patterns of TP expression were correlated with angiogenesis (anti-CD31), histopathological variables, and patient survival.
Alexandra Giatromanolaki, Michael I. Koukourakis, Constantinos Simopoulos, Alexandros Polychronidis, Adrian L. Harris, Efthimios Sivridis, Kevin C. Gatter   +6 more
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Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines

Current Pharmaceutical Biotechnology, 2001
Thymidine phosphorylase (TP) is a key enzyme in the activating pathway of 5'DFUR and capecitabine. On the other hand, TP is identical to platelet-derived endothelial cell growth factor (PD-ECGF) which is known to be an angiogenic factor. Recent studies show TP expression is increased in various malignancies compared with the surrounding normal tissues.
A. Tokue, T. Morita, A. Matsuzaki, K. Suzuki   +3 more
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Radiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines

Nucleosides, Nucleotides and Nucleic Acids, 2014
TAS-102 (trifluorothymidine [TFT] and thymidine phosphorylase inhibitor [TPI] in a molar ratio of 1:0.5) has activity in 5-fluorouracil resistant colon cancer. TPI is added to increase TFT's bioavailability. TFT has a dual mechanism of action by inhibiting thymidylate synthase and by its incorporation into DNA.
El-Naggar, M., Ebbing, E., Bijnsdorp, I.V., van den Berg, J., Peters, G.J.   +4 more
openaire   +4 more sources

Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo

International Journal of Oncology, 2003
Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous adenocarcinomas, 3 clear cell ...
Mitsuaki Suzuki, Akio Fujioka, Fumio Nakagawa, Yasushi Saga, Shizuka Tsukagoshi, Masakazu Fukushima, Norihiko Suzuki   +6 more
openaire   +3 more sources

Expression of thymidine phosphorylase and cyclooxygenase-2 in melanoma

Melanoma Research, 2013
Several studies have reported an increase in vascular structures in malignant melanoma. Neovascularization can be enhanced by several factors. Among them, thymidine phosphorylase (TP) and cyclooxygenase-2 (COX-2) have been reported to play a role. The expressions of TP and COX-2 were evaluated trough immunohistochemistry in a series of 78 primary ...
Minisini AM, Pascoletti G, Intersimone D, Poletto E, Driol P, Spizzo R, SCOTT, Cathryn Anne, PUGLISI, Fabio, Fasola G, DI LORETO, Carla   +9 more
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Localization of thymidine phosphorylase in breast cancer tissue

Medical Molecular Morphology, 2005
Thymidine phosphorylase levels are higher in some human cancer tissues than in adjacent normal tissue. However, the ultrastructural localization of thymidine phosphorylase in cancer tissue has been demonstrated only in advanced gastric and colorectal cancer.
Michiya Kobayashi, Ken Okamoto, Takeki Sugimoto, Tsutomu Namikawa, Toshiaki Moriki, Naoshige Tochika, Takehiro Okabayashi, Keijiro Araki   +7 more
openaire   +3 more sources

Thymidine phosphorylase expression in endometrial carcinomas.

Clinical & experimental metastasis, 1999
Thymidine phosphorylase (TP) is a potent angiogenic molecule shown to induce endothelial cell migration and proliferation. We investigated the expression of TP in a series of 156 endometrial carcinomas, using immunohistochemical methods. Histopathological parameters of known prognostic significance and the molecular factors of p53, bcl-2 and ...
Roy Bicknell, Efthimios Sivridis, Alexandra Giatromanolaki, Adrian L. Harris, Kevin C. Gatter, Michael I. Koukourakis   +5 more
openaire   +3 more sources

Fluorescent molecular rotors as sensors for the detection of thymidine phosphorylase

Bioorganic & Medicinal Chemistry, 2021
Three new fluorescent molecular rotors were synthesized with the aim of using them as sensors to dose thymidine phosphorylase, one of the target enzymes of 5-fluorouracil, a potent chemotherapic drug largely used in the treatment of many solid tumors, that acts by hindering the metabolism of pyrimidines.
Petaccia M., Giansanti L., Wilson J. N., Lee H., Battista S., Mancini G.   +5 more
openaire   +5 more sources