Results 131 to 140 of about 102,224 (277)

Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy

Case Reports in Anesthesiology, 2015
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP).
Vianey Q. Casarez, Acsa M. Zavala, Pascal Owusu-Agyemang, Katherine Hagan   +3 more
doaj   +1 more source

Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn’s disease

BMC Gastroenterology, 2019
Background Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn’s disease based upon clinical, imaging and pathological findings ...
Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery, Oscar Swift   +5 more
doaj   +1 more source

Late‐onset MNGIE due to partial loss of thymidine phosphorylase activity [PDF]

, 2005
Ramón Martí, Jan J.G.M. Verschuuren, Alan L. Buchman, Ikuo Hirano, Saba Tadesse, André B. P. Kuilenburg, Albert H. Gennip, Ben J. H. M. Poorthuis, Michio Hirano   +8 more
openalex   +1 more source

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Memorias do Instituto Oswaldo Cruz
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M.
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos   +8 more
doaj   +1 more source

A case of capecitabine-induced coronary microspasm in a patient with rectal cancer [PDF]

, 2007
5-Fluorouracil (5-FU) is the most frequently used chemotherapy agent concomitant with radiotherapy in the management of patients with rectal cancer. Capecitabine is an oral fluoropyrimidine that mimics the pharmaconkinetics of infusional 5-FU.
Arbea, L. (Leire), Coma-Canella, I. (Isabel), Garcia-Foncillas, J. (Jesús), Martinez-Monge, R. (Rafael)   +3 more
core   +1 more source

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy [PDF]

, 2008
Richie Soong, Nilesh Shah, Manuel Salto‐Tellez, Bee‐Choo Tai, Ross A. Soo, Han Han, S.S. Ng, Wenming Tan, Nikolajs Zeps, David Joseph, Robert B. Diasio, B Iacopetta   +11 more
openalex   +1 more source

Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

OncoTarget, 2015
The prognosis of patients with metastatic breast cancer remains poor, and thus novel therapeutic approaches are needed. Capecitabine, which is commonly used for metastatic breast cancer in different settings, is an inactive prodrug that takes advantage ...
Manuela Terranova-Barberio, M. Roca, A. Zotti, A. Leone, F. Bruzzese, C. Vitagliano, Giosuè Scogliamiglio, D. Russo, G. D’Angelo, R. Franco, A. Budillon, E. Di Gennaro   +11 more
semanticscholar   +1 more source

MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY (MNGIE) [PDF]

Acta Medica Iranica, 2006
Mitochondrial neurogastrointestinal encephalo-myopathy (MNGIE) is a rare autosomal recessive disease caused by thymidine phosphorylase (TP) gene mutation.
P. Ayatollahi, A. Tarazi S. Nafissi
doaj   +2 more sources

Thymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction. [PDF]

J Am Heart Assoc, 2023
Du L, Yue H, Rorabaugh BR, Li OQY, DeHart AR, Toloza-Alvarez G, Hong L, Denvir J, Thompson E, Li W.   +9 more
europepmc   +1 more source

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Series of Bis-1,2,4-Triazoles as Thymidine Phosphorylase Inhibitor. [PDF]

Adv Appl Bioinform Chem, 2023
Korol N, Holovko-Kamoshenkova OM, Slivka M, Pallah O, Onysko MY, Kryvovyaz A, Boyko NV, Yaremko OV, Mariychuk R.   +8 more
europepmc   +1 more source