Results 151 to 160 of about 7,658 (197)

ROLE OF THYMIDINE PHOSPHORYLASE IN AN IN VITRO MODEL OF HUMAN BLADDER CANCER INVASION [PDF]

Journal of Urology, 2002
PURPOSE: It has been previously demonstrated that the angiogenic factor thymidine phosphorylase is elevated significantly in invasive bladder cancer. We report that it is not merely an incidental finding.
Roy Bicknell, Ian Stratford, Adrian Harris   +2 more
exaly   +2 more sources

Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis [PDF]

British Journal of Cancer, 2002
Thymidine phosphorylase is an angiogenic factor primarily expressed by cancer cells, stromal cells and tumour-associated macrophages in many human malignancies.
Michael Koukourakis, Efthimios Sivridis, Adrian Harris   +2 more
exaly   +2 more sources

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Multifunctional role of thymidine phosphorylase in cancer

Trends in Cancer, 2022
Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, maintaining nucleoside homeostasis for DNA repair and replication. In many cancers TP is expressed at high levels and promotes thymidine catabolism, ultimately generating 2-deoxyribose (2dDR) that can support multiple procancer processes, including glycation of proteins,
Becka M. Warfield, Philip Reigan
openaire   +2 more sources

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

International Journal of Surgical Pathology, 2002
The expression of thymidine phosphorylase (TP), a potent chemotactic factor for enothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of imunohistochemical techniques. Results on patterns of TP expression were correlated with angiogenesis (anti-CD31), histopathological variables, and patient survival.
Alexandra, Giatromanolaki, Efthimios, Sivridis, Constantinos, Simopoulos, Alexandros, Polychronidis, Kevin C, Gatter, Adrian L, Harris, Michael I, Koukourakis   +6 more
openaire   +2 more sources

Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines

Current Pharmaceutical Biotechnology, 2001
Thymidine phosphorylase (TP) is a key enzyme in the activating pathway of 5'DFUR and capecitabine. On the other hand, TP is identical to platelet-derived endothelial cell growth factor (PD-ECGF) which is known to be an angiogenic factor. Recent studies show TP expression is increased in various malignancies compared with the surrounding normal tissues.
T, Morita, A, Matsuzaki, K, Suzuki, A, Tokue   +3 more
openaire   +2 more sources

Thymidine phosphorylase expression in endometrial carcinomas

Clinical & Experimental Metastasis, 1999
Thymidine phosphorylase (TP) is a potent angiogenic molecule shown to induce endothelial cell migration and proliferation. We investigated the expression of TP in a series of 156 endometrial carcinomas, using immunohistochemical methods. Histopathological parameters of known prognostic significance and the molecular factors of p53, bcl-2 and ...
E, Sivridis, A, Giatromanolaki, M I, Koukourakis, R, Bicknell, A L, Harris, K C, Gatter   +5 more
openaire   +2 more sources

Radiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines

Nucleosides, Nucleotides and Nucleic Acids, 2014
TAS-102 (trifluorothymidine [TFT] and thymidine phosphorylase inhibitor [TPI] in a molar ratio of 1:0.5) has activity in 5-fluorouracil resistant colon cancer. TPI is added to increase TFT's bioavailability. TFT has a dual mechanism of action by inhibiting thymidylate synthase and by its incorporation into DNA.
El-Naggar, M., Ebbing, E., Bijnsdorp, I.V., van den Berg, J., Peters, G.J.   +4 more
openaire   +4 more sources

Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo

International Journal of Oncology, 2003
Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous adenocarcinomas, 3 clear cell ...
Shizuka, Tsukagoshi, Yasushi, Saga, Norihiko, Suzuki, Akio, Fujioka, Fumio, Nakagawa, Masakazu, Fukushima, Mitsuaki, Suzuki   +6 more
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Purification of thymidine phosphorylase from human amniochorion

Biochimica et Biophysica Acta (BBA) - Enzymology, 1978
Thymidine phosphorylase (thymidine : orthophosphate deoxyribosyltransferase, EC 2.4.2.4) has been purified 1500-fold from extracts of human amniochorion. The purified enzyme catalyzes the phosphorolysis of deoxythymidine and to a lesser extent deoxyuridine but not deoxycytidine nor uridine.
J, Kubilus, L D, Lee, H P, Baden
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Thymidine phosphorylase inhibits apoptosis induced by cisplatin

Biochemical and Biophysical Research Communications, 2003
An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia. 2-Deoxy-D-ribose, a degradation product of thymidine generated by TP, partially prevents hypoxia-induced apoptosis.
Ryuji, Ikeda, Tatsuhiko, Furukawa, Ryoichi, Mitsuo, Tomohiro, Noguchi, Masaki, Kitazono, Hiroshi, Okumura, Tomoyuki, Sumizawa, Misako, Haraguchi, Xiao-Fang, Che, Hiroshi, Uchimiya, Yuich, Nakajima, Xiao Qin, Ren, Shigeru, Oiso, Ituro, Inoue, Katsushi, Yamada, Shin-ichi, Akiyama   +15 more
openaire   +2 more sources