Results 131 to 140 of about 6,430 (168)

Catabolism of thymidine in human blood platelets purification and properties of thymidine phosphorylase

Nucleic Acids and Protein Synthesis, 1981
A pyrimidine nucleoside phosphorylase was partially purified from human blood platelets. The purified enzyme, as well as crude enzyme preparations, catalyses the phosphorolysis of thymidine and deoxyuridine, but not of uridine, and is able to catalyse direct pentosyl transfer from these deoxyribonucleosides to uracil or thymine; this enzyme has the ...
G Razaka
exaly   +3 more sources

Multifunctional role of thymidine phosphorylase in cancer

Trends in Cancer, 2022
Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, maintaining nucleoside homeostasis for DNA repair and replication. In many cancers TP is expressed at high levels and promotes thymidine catabolism, ultimately generating 2-deoxyribose (2dDR) that can support multiple procancer processes, including glycation of proteins,
Becka M. Warfield, Philip Reigan
openaire   +2 more sources

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

International Journal of Surgical Pathology, 2002
The expression of thymidine phosphorylase (TP), a potent chemotactic factor for enothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of imunohistochemical techniques. Results on patterns of TP expression were correlated with angiogenesis (anti-CD31), histopathological variables, and patient survival.
Alexandra, Giatromanolaki, Efthimios, Sivridis, Constantinos, Simopoulos, Alexandros, Polychronidis, Kevin C, Gatter, Adrian L, Harris, Michael I, Koukourakis   +6 more
openaire   +2 more sources

Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines

Current Pharmaceutical Biotechnology, 2001
Thymidine phosphorylase (TP) is a key enzyme in the activating pathway of 5'DFUR and capecitabine. On the other hand, TP is identical to platelet-derived endothelial cell growth factor (PD-ECGF) which is known to be an angiogenic factor. Recent studies show TP expression is increased in various malignancies compared with the surrounding normal tissues.
T, Morita, A, Matsuzaki, K, Suzuki, A, Tokue   +3 more
openaire   +2 more sources

Thymidine phosphorylase expression in endometrial carcinomas

Clinical & Experimental Metastasis, 1999
Thymidine phosphorylase (TP) is a potent angiogenic molecule shown to induce endothelial cell migration and proliferation. We investigated the expression of TP in a series of 156 endometrial carcinomas, using immunohistochemical methods. Histopathological parameters of known prognostic significance and the molecular factors of p53, bcl-2 and ...
E, Sivridis, A, Giatromanolaki, M I, Koukourakis, R, Bicknell, A L, Harris, K C, Gatter   +5 more
openaire   +2 more sources

Radiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines

Nucleosides, Nucleotides and Nucleic Acids, 2014
TAS-102 (trifluorothymidine [TFT] and thymidine phosphorylase inhibitor [TPI] in a molar ratio of 1:0.5) has activity in 5-fluorouracil resistant colon cancer. TPI is added to increase TFT's bioavailability. TFT has a dual mechanism of action by inhibiting thymidylate synthase and by its incorporation into DNA.
El-Naggar, M., Ebbing, E., Bijnsdorp, I.V., van den Berg, J., Peters, G.J.   +4 more
openaire   +4 more sources

Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo

International Journal of Oncology, 2003
Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous adenocarcinomas, 3 clear cell ...
Shizuka, Tsukagoshi, Yasushi, Saga, Norihiko, Suzuki, Akio, Fujioka, Fumio, Nakagawa, Masakazu, Fukushima, Mitsuaki, Suzuki   +6 more
openaire   +2 more sources

Purification of thymidine phosphorylase from human amniochorion

Biochimica et Biophysica Acta (BBA) - Enzymology, 1978
Thymidine phosphorylase (thymidine : orthophosphate deoxyribosyltransferase, EC 2.4.2.4) has been purified 1500-fold from extracts of human amniochorion. The purified enzyme catalyzes the phosphorolysis of deoxythymidine and to a lesser extent deoxyuridine but not deoxycytidine nor uridine.
J, Kubilus, L D, Lee, H P, Baden
openaire   +2 more sources

Thymidine phosphorylase inhibits apoptosis induced by cisplatin

Biochemical and Biophysical Research Communications, 2003
An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia. 2-Deoxy-D-ribose, a degradation product of thymidine generated by TP, partially prevents hypoxia-induced apoptosis.
Ryuji, Ikeda, Tatsuhiko, Furukawa, Ryoichi, Mitsuo, Tomohiro, Noguchi, Masaki, Kitazono, Hiroshi, Okumura, Tomoyuki, Sumizawa, Misako, Haraguchi, Xiao-Fang, Che, Hiroshi, Uchimiya, Yuich, Nakajima, Xiao Qin, Ren, Shigeru, Oiso, Ituro, Inoue, Katsushi, Yamada, Shin-ichi, Akiyama   +15 more
openaire   +2 more sources

Detection of thymidine-phosphorylase in human blood platelets

Klinische Wochenschrift, 1973
Thymidine phosphorylase (thymidine: orthophosphate deoxyribosyltransferase, E.C.: 2.4.2.4.) was detected by thin layer chromatography using PEI cellulose plates in human blood platelets. At a final concentration of 5.6 × 10−5 M thymidine the enzyme activity attained 1 µMol per hour and 1011 platelets.
W, Schneider, C, Doenecke, P G, Scheurlen   +2 more
openaire   +2 more sources