Results 11 to 20 of about 5,593 (118)

Mycoplasma PneumoniaeThymidine Phosphorylase

Nucleosides, Nucleotides and Nucleic Acids, 2014
Mycoplasma pneumoniae (Mpn) is a human pathogen causing acute respiratory diseases and accounts for approximately 30% cases of community-acquired pneumonia. Co-infection with Mycoplasmas compromises the efficacy of anticancer and antiviral nucleoside analog-based drugs due to the presence of Mycoplasma thymidine phosphorylase (TP).
Wang, L., Schmidl, Sebastian R., Stuelke, Joerg   +2 more
openaire   +4 more sources

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma [PDF]

Japanese Journal of Cancer Research, 1996
The activity of thymidine phosphorylase (dThdPase) has heen reported to increase in several types of malignant tumors. Experimental evidence has shown that dThdPase is identical to platelet‐derived endothelial cell growth factor, and that dThdPase has angiogenic activity.
Kazutaka Yamada, Yuji Takebayashi, Suminori Akiba, Kazutaka Miyadera, Tomoyuki Sumizawa, Shin-ichi Akiyama, Takashi Aikou, Shuichi Hokita, Yuji Yamada   +8 more
openaire   +3 more sources

Thymidine phosphorylase in cancer aggressiveness and chemoresistance

Pharmacological Research, 2018
Thymidine phosphorylase (TP) is a rate-limiting enzyme in thymidine catabolism. TP has several important roles in biological and pharmacological mechanisms; importantly TP acts as an angiogenic factor and one of metabolic enzymes of fluoro-pyrimidine anticancer agents and modifies inflammation.
Shin-ichi Akiyama, Kentaro Minami, Tatsuhiko Furukawa, Sho Tabata, Kohichi Kawahara, Michiko Shimokawa, Yoshinari Shinsato, Masatatsu Yamamoto   +7 more
openaire   +2 more sources

Transition State Analysis of the Arsenolytic Depyrimidination of Thymidine by Human Thymidine Phosphorylase [PDF]

Biochemistry, 2011
Human thymidine phosphorylase (hTP) is responsible for thymidine (dT) homeostasis, promotes angiogenesis, and is involved in metabolic inactivation of antiproliferative agents that inhibit thymidylate synthase. Understanding its transition state structure is on the path to design transition state analogues.
Phillip A. Schwartz, Vern L. Schramm, Mathew J. Vetticatt   +2 more
openaire   +3 more sources

Thymidine Phosphorylase Inhibitors with a Homophthalimide Skeleton.

Biological and Pharmaceutical Bulletin, 2001
Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/ platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (9) was found to be a more potent inhibitor than the classical inhibitor, 5 ...
Tetsuya Kita, Yuichi Hashimoto, Hiroyasu Takahashi   +2 more
openaire   +4 more sources

Thymidine phosphorylase expression in normal and hyperplastic endometrium [PDF]

Journal of Clinical Pathology, 2000
To investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in normally cycling endometrium and various forms of endometrial hyperplasia.TP expression was assessed with the P-GF.44C monoclonal antibody, using the alkaline phosphatase anti-alkaline phosphatase method. Ninety two normal and hyperplastic
Adrian L. Harris, Efthimios Sivridis, Michael I. Koukourakis, Alexandra Giatromanolaki, Kevin C. Gatter, Roy Bicknell   +5 more
openaire   +3 more sources

Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Epidermal sampling of lesional, perilesional and non‐lesional skin from psoriasis and eczema patients as well as healthy skin was used to perform an in depth proteomic analysis. IL‐36γ known to be expressed in lesional psoriasis skin was outperformed by the protease inhibitor Elafin as a disease‐specific epidermal biomarker.
Anna Berekmeri, Tom Macleod, Isabel Hyde, Gregor Jan Ojak, Caroline Mann, Daniela Kramer, Martin Stacey, Miriam Wittmann   +7 more
wiley   +1 more source

Evaluating the Potential of COL8A1 as a Therapeutic Target for Chemoresistance, Disease Progression, and a Prognostic Marker in Gastric Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT This study aimed to identify key genes associated with post‐chemotherapy recurrence in gastric cancer patients. Gene expression data from multiple cohorts were analysed to determine differentially expressed genes between recurrent and non‐recurrent cases. A prognostic risk model incorporating COL8A1, HSPB7 and SLIT2 was developed and validated
Chao Xu, MuZhen He, HongYuan Chen, LiangJie Chi, XiangYu Wang, ShuYuan Li, QingShui Wang, Yao Lin, FangQin Xue   +8 more
wiley   +1 more source

Folate‐Associated Gene Expression in Primary Tumors Is Associated With Tumor Response and Progression‐Free Survival of Patients With Metastatic Colorectal Cancer Undergoing 5‐FU/Leucovorin‐Based Combination Chemotherapy

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background 5‐Fluorouracil (5‐FU) and the Folate Leucovorin (LV) form the chemotherapy backbone for metastatic colorectal cancer (mCRC). Tumoral expression of specific folate‐associated genes is associated with the risk of recurrence in stage III CRC following adjuvant 5‐FU/LV (FLV)‐based combination chemotherapy according to the Nordic bolus ...
Elisabeth Odin, Göran Carlsson, Pushpa Saksena, Anders Edsjö, Alessandro Di Cara, Roger Tell, Bengt Gustavsson, Yvonne Wettergren   +7 more
wiley   +1 more source

Adjuvant Chemotherapy May be Waived for Breast Cancer Nonresponders to Neoadjuvant Chemotherapy: A Population‐Based Large Cohort Study

Thoracic Cancer, Volume 16, Issue 9, May 2025.
Adjuvant chemotherapy (AC) showed limited benefit in breast cancer patients who did not respond to neoadjuvant chemotherapy (NAC). Overall survival was similar between those who received AC and those who did not. Multivariate and subgroup analyses confirmed no clear advantage of AC.
Lixi Li, Di Zhang, Shuning Liu, Cheng Zeng, Yalong Qi, Fei Ma   +5 more
wiley   +1 more source