Results 11 to 20 of about 102,224 (277)

Quantification of Plasma and Urine Thymidine and 2'-Deoxyuridine by LC-MS/MS for the Pharmacodynamic Evaluation of Erythrocyte Encapsulated Thymidine Phosphorylase in Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy. [PDF]

J Clin Med, 2020
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in TYMP, leading to a deficiency in thymidine phosphorylase and a subsequent systemic accumulation of thymidine and 2'-deoxyuridine.
Kipper K, Hecht M, Antunes NJ, Fairbanks LD, Levene M, Kalkan Uçar S, Schaefer A, Blakely EL, Bax BE.   +8 more
europepmc   +4 more sources

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies. [PDF]

PLoS ONE, 2020
Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation.
Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Rizwana Malik, Khalid Mohammed Khan, M Iqbal Choudhary, Atta-Ur Rahman   +6 more
doaj   +3 more sources

Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE [PDF]

Neurology, 2008
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive condition caused by mutations in the nuclear gene ECGF1 coding for thymidine phosphorylase (TP).1,2 Clinical features include gastrointestinal dysmotility, peripheral sensorimotor polyneuropathy, progressive external ophthalmoplegia, and hepatopathy.
Bain, MD, Bax, BE, Moran, NF, Muqit, MM
core   +5 more sources

The diagnostic value of IL-6 and thymidine phosphorylase in the progression of osteosarcoma

Гений oртопедии
Introduction Thymidine phosphorylase (TP) is known to be correlated with the pathogenesis of solid tumors. IL-6 is overexpressed in osteosarcoma, and data exist showing that high concentrations of IL-6 are linked to a poor prognosis.
Bushra AM Abdul Azeez, Ghufran Salman Abd Alhussain, Rabab Alhosainy Salman, Ali A. Al-Fahham   +3 more
doaj   +3 more sources

Thymidine Phosphorylase Inhibitors with a Homophthalimide Skeleton.

Biological and Pharmaceutical Bulletin, 2001
Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/ platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (9) was found to be a more potent inhibitor than the classical inhibitor, 5 ...
Tetsuya Kita, Hiroyasu Takahashi, Yuichi Hashimoto   +2 more
openalex   +4 more sources

Expression and Retention of Thymidine Phosphorylase in Cultured Reticulocytes as a Novel Treatment for MNGIE [PDF]

Molecular Therapy: Methods & Clinical Development, 2020
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal metabolic disorder caused by thymidine phosphorylase (TP) deficiency. Successful therapeutic interventions for this disease rely on a means for efficient and long-lasting ...
Marjolein Meinders, Debbie Shoemark, Johannes G.G. Dobbe, Geert J. Streekstra, Jan Frayne, Ashley M. Toye   +5 more
doaj   +2 more sources

Lysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE [PDF]

Journal of Translational Medicine
Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
Jixiang Du, Fuchen Liu, Xihan Liu, Dandan Zhao, Dongdong Wang, Hongsheng Sun, Chuanzhu Yan, Yuying Zhao   +7 more
doaj   +2 more sources

Mitochondrial neurogastrointestinal encephalomyopathy caused by thymidine phosphorylase enzyme deficiency: From pathogenesis to emerging therapeutic options [PDF]

Frontiers in Cellular Neuroscience, 2017
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a progressive metabolic disorder caused by thymidine phosphorylase (TP) enzyme deficiency.
Coo, I.F.M. (René) de, Smitt, P.S., Til, N.P. (Niek) van, van Gisbergen, M.W., Yadak, R.M.A. (Rana)   +4 more
core   +4 more sources

Targeting thymidine phosphorylase alleviates resistance to dendritic cell immunotherapy in colorectal cancer and promotes antitumor immunity. [PDF]

Front Immunol, 2022
T-cell exhaustion plays a pivotal role in the resistance of microsatellite-stable colorectal cancer (CRC) to immunotherapy. Identifying and targeting T-cell exhaustion-activating mechanisms is a promising strategy to augment the effects of immunotherapy.
Paladhi A, Daripa S, Mondal I, Hira SK.
europepmc   +2 more sources

Distinct substrate specificity and physicochemical characterization of native human hepatic thymidine phosphorylase. [PDF]

PLoS ONE, 2018
Thymidine phosphorylase (TP; EC 2.4.2.4) is involved regulation of intra- or extracellular thymidine concentration, angiogenesis, cancer chemotherapy, radiotherapy, as well as tumor imaging.
Taesung Oh, Mahmoud H El Kouni
doaj   +2 more sources