Results 21 to 30 of about 5,593 (118)
Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman +5 more
wiley +1 more source
Thymidine phosphorylase is angiogenic and promotes tumor growth. [PDF]
Proceedings of the National Academy of Sciences, 1995 Platelet-derived endothelial cell growth factor was previously identified as the sole angiogenic activity present in platelets; it is now known to be thymidine phosphorylase (TP). The effect of TP on [methyl-3H]thymidine uptake does not arise from de novo DNA synthesis and the molecule is not a growth factor.
Adrian L. Harris +9 more
openaire +3 more sources
Cancer Medicine, Volume 14, Issue 7, April 2025.ABSTRACT Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel combination of trifluridine/tipiracil with oxaliplatin as induction chemotherapy (IC) followed by CRT ...
Sarbajit Mukherjee +18 more
wiley +1 more source
Highlights From the 2nd Turin International Workshop on Liver Machine Perfusion
Artificial Organs, Volume 49, Issue 4, Page 716-721, April 2025.ABSTRACT The 2nd Turin International Workshop on Liver Machine Perfusion took place in Turin, Italy, on November 22, 2024. Leading experts came together to discuss the current applications, limitations, and future directions of this technology, with a primary focus on but not limited to liver transplantation.
Damiano Patrono +5 more
wiley +1 more source
MedComm, Volume 6, Issue 3, March 2025.5‐Fluorouracil (5‐FU) treatment triggers the Ras‐responsive element binding protein 1 (RREB1) expression and the formation of RREB1 and lysine demethylase 1A (KDM1A) complex which binds to the promoter of thymidylate synthase (TS) and thymidine kinase (TK1), and be recruited to phosphorylated H2AX foci, contributing to reduced DNA damage and enhanced ...
Ya‐Nan Deng +10 more
wiley +1 more source
Thoracic Cancer, Volume 16, Issue 3, February 2025.ABSTRACT Introduction The purpose of this study is to determine the efficacy and safety of metronomic chemotherapy with all‐oral combination of low‐dose etoposide/capecitabine in patients with metastatic breast cancer (MBC) previously treated with anthracyclines and/or taxanes.
Xue Chen, Yingjian He, Tie Fan, Yan Wei
wiley +1 more source
Asia-Pacific Journal of Clinical Oncology, Volume 21, Issue 1, Page 31-45, February 2025.An Asia‐Pacific expert consensus panel developed eight evidence‐based recommendations for the optimal management of BRAFV600E‐mutant metastatic colorectal cancer (mCRC). We recommend molecular testing to guide individualized therapy, propose treatment pathways according to microsatellite stability status, advocate for more frequent monitoring of ...
Oliver Piercey +8 more
wiley +1 more source
European Journal of Neuroscience, Volume 61, Issue 3, February 2025.The blood–brain barrier (BBB) is fundamental for maintaining cerebral homeostasis and vascular function. Cerebral endothelial cells are an important part of the BBB. Ineffective reperfusion may occur during ischemia–reperfusion in stroke. Ineffective reperfusion can damage endothelial cells through a variety of mechanisms (including disturbance of ...
Xiang Li +5 more
wiley +1 more source
Transgenerational Plasticity of Maternal Hemolymph Trehalose in Aphids
Archives of Insect Biochemistry and Physiology, Volume 118, Issue 1, January 2025.Maternal hemolymph trehalose influences aphid transgenerational plasticity and adaptation to environmental stress. Higher trehalose levels in winged aphids are associated with increased trehalose levels in the offspring, potentially aiding resilience.
Naomi Soma, Shingo Kikuta
wiley +1 more source
Thymidine Phosphorylase Participates in Platelet Signaling and Promotes Thrombosis [PDF]
Circulation Research, 2014 Rationale : Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expressed in diseases with high risk of thrombosis, such as atherosclerosis and type II diabetes mellitus. Objective :
Li, Wei +6 more
openaire +4 more sources