Results 21 to 30 of about 102,224 (277)

Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes. [PDF]

BMC Med, 2022
Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyuridine, to thymine and uracil. Biallelic TYMP
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I.   +17 more
europepmc   +2 more sources

Thymidine phosphorylase in cancer aggressiveness and chemoresistance

Pharmacological Research, 2018
Thymidine phosphorylase (TP) is a rate-limiting enzyme in thymidine catabolism. TP has several important roles in biological and pharmacological mechanisms; importantly TP acts as an angiogenic factor and one of metabolic enzymes of fluoro-pyrimidine anticancer agents and modifies inflammation.
Tatsuhiko, Furukawa, Sho, Tabata, Masatatsu, Yamamoto, Kohichi, Kawahara, Yoshinari, Shinsato, Kentaro, Minami, Michiko, Shimokawa, Shin-Ichi, Akiyama   +7 more
openaire   +3 more sources

Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis. [PDF]

Bioeng Transl Med, 2021
Macrophages are generally thought to play a key role in the pathogenesis of aseptic loosening through initiating periprosthetic inflammation and pathological bone resorption.
Matsumae G, Shimizu T, Tian Y, Takahashi D, Ebata T, Alhasan H, Yokota S, Kadoya K, Terkawi MA, Iwasaki N.   +9 more
europepmc   +2 more sources

Thymidine Phosphorylase from Escherichia coli. Properties and Kinetics [PDF]

European Journal of Biochemistry, 1971
Marianne Schwartz
openalex   +4 more sources

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer

Journal of Medicinal Chemistry, 2019
Overexpressed human thymidine phosphorylase (hTP) has been associated with cancer aggressiveness and poor prognosis by triggering proangiogenic and antiapoptotic signaling.
Nathalia Sperotto, Candida Deves Roth, Valnês S. Rodrigues-Junior, Christiano Ev Neves, Fávero Reisdorfer Paula, Adílio da Silva Dadda, Pedro Bergo, Talita Freitas de Freitas, Fernanda Souza Macchi, Sidnei Moura, Ana Paula Duarte de Souza, Maria M. Campos, Cristiano Valim Bizarro, Diógenes Santiago Santos, Luiz Augusto Basso, Pablo Machado   +15 more
openalex   +3 more sources

Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil. [PDF]

Br J Cancer, 2023
Yang B, Xie X, Lv D, Hu J, Chen Y, Wu Z, Luo S, Zhang S.   +7 more
europepmc   +3 more sources

Thymidine Phosphorylase Inhibitory Potential and Molecular Docking Studies of Secondary Metabolites Isolated From Fernandoa adenophylla (Wall. ex G. Don) Steenis. [PDF]

Chem Biodivers
ABSTRACT This study investigates the potential of Fernandoa adenophylla, a South American plant, as a reservoir of compounds with thymidine phosphorylase (TP) inhibitory activity. Through a comprehensive approach combining in vitro assays and molecular docking analysis, we isolated and characterized bioactive compounds from F.
Rauf A, Khan M, Rashid U, Saeed A, Shah ZA, Ahmad Z, Alamri AS, Alsanie WF, Khan I, Hussain H, Alhomrani M, Iriti M.   +11 more
europepmc   +2 more sources

Erythrocyte Encapsulated Thymidine Phosphorylase for the Treatment of Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy: Study Protocol for a Multi-Centre, Multiple Dose, Open Label Trial [PDF]

Journal of Clinical Medicine, 2019
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder which primarily affects the gastrointestinal and nervous systems.
Bridget E. Bax, Michelle Levene, Murray Bain, Lynette D. Fairbanks, Massimiliano Filosto, Sema Kalkan Uçar, Thomas Klopstock, Cornelia Kornblum, Hanna Mandel, Shamima Rahman, Agathe Roubertie, Mauro Scarpelli, P. Sedgwick, Moshe Baru, M. Sellos-Moura, J.D.E. Price, Patrick T. Horn, Niranjanan Nirmalananthan   +17 more
openalex   +2 more sources

Mitochondrial neurogastrointestinal encephalomyopathy: Clinical and biochemical impact of allogeneic stem cell transplantation in a Greek patient with one novel TYMP mutation

Molecular Genetics and Metabolism Reports, 2022
We describe the case of a Greek female patient with the Classic form of the ultra- rare and fatal autosomal recessive disorder Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) and the impact of allogeneic hematopoietic stem cell ...
A. Paisiou, M. Rogalidou, R. Pons, E. Ioannidou, K. Dimakou, A. Papadopoulou, F.M. Vaz, G. Vessalas, S.M.I. Goorden, J. Roelofsen, A. Zoetekouw, M.M. Nieman, E. Dimitriou, M. Moraitou, I. Peristeri, H. Michelakakis, A.B.P. van Kuilenburg   +16 more
doaj   +1 more source

Safety and Efficacy of Erythrocyte Encapsulated Thymidine Phosphorylase in Mitochondrial Neurogastrointestinal Encephalomyopathy. [PDF]

J Clin Med, 2019
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare autosomal recessive disorder of nucleoside metabolism that is caused by mutations in the nuclear thymidine phosphorylase gene (TYMP) gene, encoding for the enzyme thymidine ...
Levene M, Bain MD, Moran NF, Nirmalananthan N, Poulton J, Scarpelli M, Filosto M, Mandel H, MacKinnon AD, Fairbanks L, Pacitti D, Bax BE.   +11 more
europepmc   +2 more sources