Results 151 to 160 of about 124,338 (379)
Oxidative thymine mutation in DNA: water-wire-mediated proton-coupled electron transfer.
Journal of the American Chemical Society, 2013 One-electron oxidation of A/T-rich DNA leads to mutations at thymine. Experimental investigation of DNA containing methyl-deuterated thymine reveals a large isotope effect establishing that cleavage of this carbon-hydrogen bond is involved in the rate ...
R. Barnett +3 more
semanticscholar +1 more source
Unexpected hydrogen dissociation in thymine: predictions from a novel coupled cluster theory [PDF]
arXivThe fate of thymine upon excitation by ultraviolet radiation has been the subject of intense debate over the past three decades. Today, it is widely believed that its ultrafast excited state decay stems from a radiationless transition from the bright ${\pi}{\pi}^*$ state to a dark $n{\pi}^*$ state. However, conflicting theoretical predictions have made
arxiv
Automated DNA Motif Discovery [PDF]
arXiv, 2010 Ensembl's human non-coding and protein coding genes are used to automatically find DNA pattern motifs. The Backus-Naur form (BNF) grammar for regular expressions (RE) is used by genetic programming to ensure the generated strings are legal. The evolved motif suggests the presence of Thymine followed by one or more Adenines etc.
arxiv
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source
Correlation Dynamics and Enhanced Signals for Serial DNA Sequencing
, 2013 Nanopore based sequencing has demonstrated significant potential for the development of fast, accurate, and cost-efficient fingerprinting techniques for next generation molecular detection and sequencing.
Ahmed, Towfiq +5 more
core +1 more source
arXiv, 2013 Present day data allow significant reconsideration of ideas on mechanisms underlying the degeneracy in the genetic code. Here a hypothesis is presented which links the degeneracy to possible conformational alterations in the codon-anticodon duplex. This enables explanation of Rumer symmetry in the table of the genetic code, coding of methionine and ...
arxiv
Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy +7 more
wiley +1 more source
A Middle and Late Devensian sequence from the northern part of Kents Cavern (Devon, UK)
Journal of Quaternary Science, EarlyView.Abstract 1920s/30s excavation of a Middle Devensian sequence in the northern part of Kents Cavern recovered important Late Middle and Early Upper Palaeolithic archaeological material, including Britain's oldest known Homo sapiens remains. Questions remain about this material, including how it came to be in the cave.
Rob Dinnis +11 more
wiley +1 more source
Substitution of Thymine for “Folic Acid” in the Nutrition of Lactic Acid Bacteria [PDF]
, 1944 J. L. Stokes
openalex +1 more source
Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond
Macromolecular Bioscience, EarlyView.Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley +1 more source