Results 141 to 150 of about 65,072 (224)

A Lambda Red Recombinase‐Assisted CRISPR/Cas9 System for Efficient and Precise Genome Editing in Agrobacterium tumefaciens

Plant Biotechnology Journal, EarlyView.
ABSTRACT Agrobacterium tumefaciens is a powerful delivery tool for plant genetic transformation and a pivotal platform for agricultural biotechnology. However, laboratory strains of Agrobacterium have remained genetically unoptimized for decades, with genome engineering hindered by inefficient, endogenous homologous recombination systems.
Minmin Zheng, Rui Liu, Wei‐Chang Huang, Zuren Li, Kai Hua   +4 more
wiley   +1 more source

Identification of a Susceptibility Gene for Xanthomonas oryzae pv. oryzae in Vietnamese Elite Rice (Oryza sativa L.) Cultivar Bacthom 7

Plant Breeding, EarlyView.
ABSTRACT Xanthomonas oryzae pv. oryzae (Xoo) is the causal agent of bacterial leaf blight (BLB) disease in rice, exerting a detrimental impact on the yield of various rice cultivars in Vietnam, notably the Bacthom 7 (BT7) variety. Xoo possesses transcription activator‐like effectors (TALEs) which modulate the expression of host genes by specifically ...
Nguyen Duy Phuong, Dong Huy Gioi, Cao Le Quyen, Nguyen Xuan Hung, Ha Hai Yen, Bui Thi Thu Huong, Sebastien Cunnac, Tran Dang Xuan, Pham Xuan Hoi   +8 more
wiley   +1 more source

Spectroscopic analysis of bacterial photoreactivation

Photochemistry and Photobiology, Volume 101, Issue 2, Page 494-504, March/April 2025.
This study investigates the effectiveness of fluorescence and Raman spectroscopy in detecting bacterial photoreactivation. Fluorescence spectroscopy shows limitations, because the intense fluorescence of tryptophan and tyrosine masks fluorescence emitted by thymine molecules.
Keyvan Khosh Abady, Negar Karpourazar, Arjun Krishnamoorthi, Runze Li, Peter M. Rentzepis   +4 more
wiley   +1 more source

Revisiting the action spectrum of DNA damage: Chemiexcitation and the expanded biological spectrum of cyclobutane pyrimidine dimer formation

Photochemistry and Photobiology, EarlyView.
UVB and UVA generate cyclobutane pyrimidine dimers (CPDs) during irradiation (purple). After exposure ends, chemiexcitation in pigmented melanocytes continues to generate delayed CPDs (yellow), even as repair removes some pre‐existing lesions. Consequently, total CPD burden can rise while visible erythema fades.
Jyoti Srivastava, Marcus S. Cooke, Sanjay Premi   +2 more
wiley   +1 more source

UV signature mutation hyperhotspots as genomic dosimeters

Photochemistry and Photobiology, EarlyView.
Recurrent UV signature mutations are a sensitive and specific indicator of sun exposure. UV signature mutations (C → T mutations at dipyrimidine sites) were quantified using Duplex Sequencing and a stringent mutation calling protocol to identify true low‐abundance mutations.
Vijay Menon, Alejandro García‐Ruiz, Susan Neveu, Brenda Cartmel, Leah M. Ferrucci, Meg Palmatier, Christine Ko, Kenneth Y. Tsai, Mio Nakamura, Sa Rang Kim, Michael Girardi, Karl Kornacker, Douglas E. Brash   +12 more
wiley   +1 more source

Dynamic Surface‐Enhanced Raman Scattering Platform With Multiscale Nanostructural Engineering and Programmable Surface Energy for Artificial Intelligence‐Assisted Discrimination of Helicobacter pylori

Advanced Oncology, Volume 1, Issue 1, December 2026.
This study develops a dynamic surface‐enhanced Raman scattering (D‐SERS) platform integrating multiscale nanoparticle geometry, quantum dot coupling, surface‐energy programming, and a multilayer perceptron model for AI‐assisted classification. It enables ultrahigh sensitivity, noninvasive detection, and specific Helicobacter pylori identification.
Ming‐Chang Lu, Chia‐Jung Lee, Chih‐Yuan Yao, Bo‐Ying Wu, Chih‐Wei Chiu   +4 more
wiley   +1 more source

Loss of DNA methylation is not associated with venetoclax–hypomethylating agents synergy in acute myeloid leukaemia cells

British Journal of Haematology, EarlyView.
Aida Selimović‐Pašić, Lisa Haglund, Maike Bensberg, Júlia Goldmann, Padraig D'arcy, Sandra Hellberg, Colm E. Nestor   +6 more
wiley   +1 more source

Minimally processed, human‐grade diet alters canine epigenetic ageing: Results from a pilot study

Veterinary Record Open, Volume 13, Issue 2, December 2026.
Abstract Background Diet plays a critical role in promoting wellness and longevity in both humans and canines. Epigenetic ageing clocks have emerged as accurate tools for assessing biological ageing and evaluating dietary and lifestyle interventions in humans and mice.
Aimee Chen, Wei Guo, Janina A. Krumbeck, Dan Su, Vincent Michels, Xiaojing Yang   +5 more
wiley   +1 more source

Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome

International Journal of Cancer, Volume 159, Issue 10, Page 2585-2594, 15 November 2026.
ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin, Dong Keon Kim, Yoojeong Seo, Hyeon Hee Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Jongwon Oh, Sanghoo Lee, Tae Il Kim   +10 more
wiley   +1 more source

Cancer and Hypertension: Shared Mechanisms, Treatment Interactions, and Clinical Management

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer and hypertension (HTN) frequently coexist, and their relationship is increasingly recognized as a clinically relevant intersection between oncology and cardiovascular medicine. However, the extent to which this association reflects shared risk factors, common biological mechanisms, or treatment‐related effects remains incompletely ...
Peizhi Jia, Daxin Chen, Jingting Wang, Yupei Guo, Jinhong Liu, Jiumao Lin   +5 more
wiley   +1 more source