Results 161 to 170 of about 60,531 (292)

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, Volume 13, Issue 32, 9 June 2026.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

Is It Possible to Trap 4HNE, the Main Degradation Product of Omega-6? A Theoretical Study of Potential Scavengers. [PDF]

ACS Omega
Ramírez R, Martínez A.
europepmc   +1 more source

UV Irradiation of Thymine Molecules and Gas Chromatography – Mass Spectrometry

, 2017
Cyclobutane pyrimidine dimers (CPDs) are products of a photochemical reaction caused by ultraviolet (UV) irradiation of adjacent pyrimidine molecules. Thymine dimers, the most common form of CPDs in the body, are of particular interest because they are ...
Mauk, Kelsey Elaine
core  

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

Functionalizing Nucleobases With Boronic Acids and Boronic Acid Esters: Thymine Derivatives and Their Dioxazaborocane Chemistry

ChemPlusChem, Volume 91, Issue 6, June 2026.
Boronic acid‐substituted thymine derivatives are well established and exhibit a range of biological activities. In contrast, the corresponding boronic acid esters and dioxazaborocane analogs remain largely unexplored. Herein, we report the synthesis and structural characterization of thymine derivatives bearing boronic acid, boronic acid ester, and ...
Tabea Lenz, Marcus Layh, Marian Hebenbrock   +2 more
wiley   +1 more source

Whole Exome Sequencing Reveals Potential Single Nucleotide Polymorphisms and Copy Number Variations in 26 Sporadic Patients with Immature Teratoma. [PDF]

Int J Gen Med
Liu Y, Jia Y, Du N, Li Y, Wang C, Kang S.   +5 more
europepmc   +1 more source

Mitochondrial Genome of the Indo‐Pacific Mesophotic Coral Leptoseris columna (Scleractinia: Agariciidae) Assembled Using PacBio Long‐Read Sequencing

Ecology and Evolution, Volume 16, Issue 6, June 2026.
The complete mitochondrial genome of Leptoseris columna was assembled using PacBio long read sequencing. ABSTRACT Leptoseris columna, a mesophotic coral species belonging to the family Agariciidae, is distributed throughout the Indo‐Pacific region.
Nomita Rani Adhikary, Daniel J. Barshis, J. Antonio Baeza   +2 more
wiley   +1 more source

Structural basis for uracil removal from DNA by human SMUG1. [PDF]

Nat Commun
Ludäscher JM, Scaletti Hutchinson E, Vila-Julià G, Jemth AS, Shahid S, Wiita E, Cabeza de Vaca I, Pach S, Gajdos L, Aggarwal S, Walse E, Mortusewicz O, Helleday T, Carlsson J, Stenmark P.   +14 more
europepmc   +1 more source

Radiation Chemistry of Thymine in Aqueous Alkaline Solution

, 1964
Gamma radiolysis of thymine solutions was investigated over a wide pH range using ultraviolet absorption spectra and two-dimensional paper chromatography combined with radioautography. The results show that as the pH is increased, the spectrum change for
Tsukamoto, W. T., Ward, J. F., Julca, J. R., Holmes, D. E.   +3 more
core  

The Great Bustard (Otis tarda) and Common Crane (Grus grus) Utilize Food Resources via Gut Microbiota Remodeling During Wintering in the Yellow River Wetlands in Ordos City, Inner Mongolia, China

Ecology and Evolution, Volume 16, Issue 6, June 2026.
This study detected the diet and gut microbiota of great bustards and common cranes in the wintering duration in the Yellow River Wetlands of Inner Mongolia using high‐throughput sequencing technology. This study indirectly indicated that great bustards and common cranes are well‐adapted to the environment of the Yellow River Wetlands during the ...
Li Gao, Haitao Fang, Hongda Pei, Junlan Li, Li Liu   +4 more
wiley   +1 more source