Results 181 to 190 of about 60,531 (292)

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

open access: yesMedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina   +5 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang   +7 more
wiley   +1 more source

Validating Oxford Nanopore Technologies Amplicon Sequencing as an Alternative to Sanger Sequencing for Generating Plant Molecular Markers

open access: yesNew Zealand Journal of Botany, Volume 64, Issue 2, June 2026.
Molecular phylogenetic markers used to be ubiquitously obtained by Sanger sequencing, while recently, next generation sequencing (NGS) approaches have become popular alternatives. In this study, a pipeline utilizing Oxford Nanopore Technologies (ONT) amplicon sequencing (amplicon‐seq) was examined as an alternative to Sanger sequencing, with nine loci [
Kanae Nishii   +7 more
wiley   +1 more source

Thymine DNA glycosylase binds to R-loops and excises 5-formyl and 5-carboxyl cytosine from DNA/RNA hybrids. [PDF]

open access: yesJ Biol Chem
Zhu B   +7 more
europepmc   +1 more source

Global Quantitative Analysis of Ligation Reactions in Self‐Assembled DNA Nanostructures at the Single‐Nick Level

open access: yesSmall, Volume 22, Issue 33, 12 June 2026.
Ligations of staple strands by ligase at 64 nick sites on DNA origami can be quantitatively mapped. While ligations preferentially occur at the trapezoid edges rather than at inner sites, excellent agreement between the experimental ligation yields and docking simulations suggests that this is a result of variations in the ligase docking probability ...
Konrad Hacker   +5 more
wiley   +1 more source

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